Tumor Necrosis Factor-Alpha and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice

    July 2009 in “ Cancer Research ”
    David Surguladze, Dhanvanthri S. Deevi, Nidia Claros, Erik Corcoran, Su Wang, Mary Jane Plym, Yan Wu, Jacqueline Doody, David J. Mauro, Larry Witte, Klaus J. Busam, Bronek Pytowski, Ulrich Rodeck, James R. Tonra
    TLDR Blocking certain proteins can reduce skin inflammation caused by cancer treatment.
    The study demonstrated that the monoclonal antibody ME1, targeting murine EGFR, induced neutrophil-rich hair follicle inflammation in mice, resembling the acneiform rash seen in cancer patients undergoing EGFR antibody therapy. This inflammation was associated with lipid-filled hair follicle distensions and enlarged sebaceous glands. The cytokine TNFα was up-regulated in the affected skin regions, and its involvement in the inflammatory process was confirmed by the reduction of skin inflammation through cotreatment with the TNFα inhibitor, etanercept. Additionally, the interleukin-1 antagonist Kineret was effective, suggesting that interleukin-1 also played a role. These findings provided a mechanistic basis for developing evidence-based treatments for EGFR antibody-induced skin rashes in cancer patients.
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