Tumor Necrosis Factor-Alpha and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice

    July 2009 in “ Cancer Research
    David Surguladze, Dhanvanthri S. Deevi, Nidia Claros … James R. Tonra
    Studysummary In this mouse study, the researchers found that the monoclonal antibody ME1 causes hair follicle inflammation by up-regulating TNFα, which can be reduced by TNFα and interleukin-1 inhibitors.
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    Research cited in this study 3

    1. Skin Toxicity Caused by EGFR Antagonists: An Autoinflammatory Condition Triggered by Deregulated IL-1 Signaling? Journal of Cellular Physiology · 2008
    2. Acne and Sebaceous Gland Function Clinics in dermatology · 2004
    3. Epidermal Growth Factor as a Biological Switch in Hair Growth Cycle Journal of biological chemistry/˜The œJournal of biological chemistry · 2003