Scarring Alopecia in Tumor Necrosis Factor-Alpha Antagonists-Induced Scalp Psoriasis

April 2023 in “ Journal of Psoriasis and Psoriatic Arthritis ”

Avital Baniel, A. Peled, Liat Samuelov, Valentina Zemser, Andrea Gat, Roni P. Dodiuk‐Gad, Michael Ziv, Wassim Azzam, Eran Zittan, Hagit Matz, Eli Sprecher, Mor Pavlovsky

scarring alopecia tumor necrosis factor-alpha TNFα inhibitors psoriatic alopecia scalp psoriasis TNF-alpha inhibitors

TLDR Early diagnosis and treatment are crucial to prevent permanent hair loss from TNFα inhibitors in scalp psoriasis.

The document discusses the rare occurrence of psoriatic alopecia associated with the use of TNFα inhibitors. It emphasizes the importance of maintaining a high level of suspicion and making a prompt diagnosis to prevent irreversible damage. Early intervention is crucial in managing this condition effectively.

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Research cited in this study

14 / 14 results

research Psoriatic Alopecia in a Patient With Crohn's Disease: An Uncommon Manifestation of Tumor Necrosis Factor Alpha Inhibitors

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A girl with Crohn's disease developed hair loss due to her increased medication, a rare side effect seen in some children.

research Adalimumab-Induced Scalp Psoriasis with Severe Alopecia

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Stopping adalimumab and starting methotrexate with topical treatments improved the woman's scalp psoriasis and hair regrew.

research TNF-Inhibitor Associated Psoriatic Alopecia: Diagnostic Utility of Sebaceous Lobule Atrophy

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Shrinking of oil glands in the skin is a key sign of hair loss linked to TNF inhibitor drugs and may improve if the treatment is stopped.

research Adalimumab-Related Alopecia in a Patient Affected by Psoriasis

14 citations , January 2017 in “Dermatology Online Journal”

Adalimumab can cause hair loss and scalp issues in some psoriasis patients.

research TNF Inhibitor Induced Alopecia: An Unusual Form of Psoriasiform Alopecia That Breaks the Renbök Mold

9 citations , January 2017 in “Dermatology Online Journal”

Some hair loss drugs can cause a unique type of hair loss that resembles both psoriasis and alopecia.

research Tumor Necrosis Factor-Induced Alopecia: Alternative Pathology and Therapy

7 citations , January 2017 in “Dermatology Online Journal”

TNF-inhibitor induced alopecia can be treated effectively with different therapies.

research Alopecia Secondary to Anti-Tumor Necrosis Factor-Alpha Therapy

42 citations , March 2015 in “Anais Brasileiros de Dermatologia”

Anti-TNF therapy can cause hair loss and skin issues.

research Adalimumab-Induced Psoriatic Alopecia/Alopecia Areata-Like Reaction in a Patient with Crohn's Disease

9 citations , January 2015 in “Dermatology Online Journal”

A patient with Crohn's disease grew back their hair after stopping Adalimumab, which had caused hair loss.

research Alopecia Universalis Successfully Treated With Adalimumab

37 citations , October 2014 in “JAMA dermatology”

A woman with severe hair loss was successfully treated with the drug adalimumab.

research Anti-TNF-Alpha Induced Psoriasiform Eruptions with Severe Scalp Involvement and Alopecia: Report of Five Cases and Review of the Literature

49 citations , January 2012 in “Dermatology”

Severe anti-TNF-α induced scalp eruptions often need stopping the drug and using systemic therapy to avoid scarring.

Psoriatic Alopecia/Alopecia Areata–Like Reactions Secondary to Anti–Tumor Necrosis Factor-α Therapy: A Novel Cause of Noncicatricial Alopecia

research Psoriatic Alopecia/Alopecia Areata–Like Reactions Secondary to Anti–Tumor Necrosis Factor-α Therapy: A Novel Cause of Noncicatricial Alopecia

72 citations , February 2011 in “The American Journal of Dermatopathology”

Anti-TNF therapy can cause a unique type of hair loss that may get better with topical treatments without stopping the therapy.

research Development of Alopecia Areata Universalis in a Patient Receiving Adalimumab

69 citations , December 2006 in “Archives of dermatology”

Adalimumab may cause severe hair loss in some patients.

research Recurrence of Alopecia Areata in a Patient Receiving Etanercept Injections

75 citations , June 2005 in “Archives of Dermatology”

Etanercept may not prevent alopecia areata from coming back.

research Cytokines and Growth Factors Influence Hair Growth In Vitro: Possible Implications for the Pathogenesis and Treatment of Alopecia Areata

91 citations , March 1996 in “Archives of Dermatological Research”

Certain cytokines and growth factors can inhibit hair growth and may affect alopecia areata.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community DUPA/Retrograde might not be DHT based...GET A BIOPSY QUICK or permanent Hair Loss!

in Research/Science 39 upvotes 1 year ago

DUPA and retrograde alopecia may not be solely DHT-based, and a biopsy is crucial for accurate diagnosis and treatment. Treatments mentioned include dutasteride, oral minoxidil, pioglitazone, clobetasol, calcipotriol, ketoconazole, and doxycycline, depending on the specific condition.

community Holy shit. Verteporfin may actually be the cure

in Research/Science 1017 upvotes 2 years ago

The post and conversation discuss Verteporfin's potential as a hair loss treatment. It's shown promise in regrowing hair after transplants and might be effective with microneedling.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 734 upvotes 3 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Hair loss research is a money grab

in Chat 225 upvotes 4 months ago

Hair loss is linked to DHT, with treatments like finasteride and minoxidil being common but not definitive. Economic interests influence research, and there is potential for new treatments like PP405 and RU58841.

community 1.5 years finasterite. 1 tablet daily. Don't see any improvement.

in Is this regrowth? 114 upvotes 4 months ago

The user has been taking finasteride for 1.5 years without seeing improvement in hair regrowth. Suggestions include adding minoxidil or switching to dutasteride, with concerns about side effects.

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