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Glossary Transforming Growth Factor

proteins regulating cell growth, differentiation, and immune responses

Transforming Growth Factor (TGF) refers to a group of proteins that play crucial roles in regulating cell growth, differentiation, and immune responses. There are two main types, TGF-α and TGF-β, with TGF-β being particularly important in processes like wound healing, fibrosis, and the regulation of the immune system. These factors are significant in both normal physiological processes and in the development of diseases such as cancer and fibrosis.

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research Role of Dermal Factors Involved in Regulating the Melanin and Melanogenesis of Mammalian Melanocytes in Normal and Abnormal Skin

April 2024 in “International journal of molecular sciences”

This review examined and discussed the role of dermis-derived factors in the regulation of melanogenesis, noting their significance in both normal and abnormal mammalian skin conditions, suggesting an underexplored area of study compared to dermal and epidermal influences.

research Estrogens and the skin

137 citations , June 2005 in “Climacteric”

This review indicates that estrogen loss during menopause significantly impacts skin health, while estrogen treatment may increase skin collagen, thickness, and elasticity, though effects on other skin characteristics are inconsistent.

research Role of platelet rich plasma gel in the wound healing of black Bengal goat

12 citations , January 2013 in “IOSR Journal of Agriculture and Veterinary Science”

In this study, homogenous platelet rich plasma gel improved wound healing in goats, showing organized collagen and new hair growth within 15 days without inflammation.

research Modulating the stem cell niche for tissue regeneration

480 citations , August 2014 in “Nature Biotechnology”

This review discusses manipulating the stem cell niche as a strategy in regenerative medicine to repair damaged tissues, highlighting the potential benefits and challenges but reporting no new results.

research A human prenatal skin cell atlas reveals immune cell regulation of skin morphogenesis

October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study constructed a comprehensive atlas of prenatal human skin, revealing that innate immune cells, such as macrophages, play a crucial role in skin morphogenesis by interacting with non-immune cells, influencing hair follicle formation and angiogenesis beyond their traditional immune functions.

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community A Theory on Why Microneedling Works

175 upvotes 6 years ago

Microneedling may enhance hair regrowth by transferring stem cells to dormant follicles, improving the effects of minoxidil. Users discuss using microneedling with needle lengths around 1.5mm to stimulate hair growth.

community Taurine supplements work for hair growth?

9 upvotes 2 years ago

The conversation discusses taurine supplements for hair growth, highlighting their potential to reduce DHT and improve hair health. A user comments that people often try alternatives to finasteride.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

211 upvotes 1 year ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community The Real Cause Of Androgenetic Alopecia

675 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Amplifica: Hope or Cope? A Review of Their Pipeline

9 upvotes 1 month ago

Amplifica's AMP-303 showed a modest increase in hair growth, but results were inconsistent and potentially misleading. Hyaluronic acid and osteopontin are being explored for hair growth, with varying effects on different hair types and conditions.

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