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GlossaryTranscription Co-activator

protein that helps activate gene expression by binding to transcription factors

A transcription co-activator is a protein that helps turn on the expression of specific genes by binding to transcription factors, which are proteins that directly interact with DNA. While co-activators do not bind to DNA themselves, they facilitate the assembly of the transcription machinery, enhancing the efficiency of gene transcription. This process is crucial for regulating various biological functions, including hair growth and the response to conditions like alopecia.

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The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function

research The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function

72 citations, January 2003 in “American Journal of Pathology”

A protein called CBP is found in prostate cancer and can increase the effectiveness of certain prostate cancer treatments.

research Expression and Function of Nuclear Receptor Co-Activator 4: Evidence of a Potential Role Independent of Co-Activator Activity

26 citations, May 2012 in “Cellular and Molecular Life Sciences”

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

Probing Androgen Receptor Co-Factor Selectivity Profiles: A Chemical Tool to Determine Cross-Talk Between Androgen Receptor and Beta-Catenin In Vivo

research Probing Androgen Receptor Co-Factor Selectivity Profiles: A Chemical Tool to Determine Cross-Talk Between Androgen Receptor and Beta-Catenin In Vivo

1 citations, January 2013 in “MedChemComm”

PF-05314882 selectively activates androgen receptors without much effect on prostate and may help in prostate cancer treatment and hair loss prevention.

GLI2-Specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells

research GLI2-Specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells

39 citations, May 2008 in “Journal of biological chemistry/The Journal of biological chemistry”

GLI2 increases follistatin production in human skin cells.

research Regulatory T Cells: The Many Faces of Foxp3

125 citations, September 2019 in “Journal of Clinical Immunology”

Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.

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community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 96 upvotes 4 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community New Research- Creatine Increasing Scalp DHT Without Corresponding Serum DHT Increase

in Research/Science 120 upvotes 4 months ago

Creatine may increase scalp DHT without affecting serum DHT, potentially speeding up male pattern baldness (MPB) for those genetically prone. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 1 month ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 37 upvotes 1 year ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

community Testosterone in Reference Range Doesn't Cause Hair Loss

in Research/Science 51 upvotes 7 months ago

Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.

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