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Glossary Topical Finasteride

medication applied to the scalp to treat hair loss

Topical Finasteride is a medication applied directly to the scalp to treat hair loss, particularly androgenetic alopecia (male or female pattern baldness). Unlike oral finasteride, which can have systemic side effects, the topical form aims to reduce these risks by delivering the drug directly to the affected area, thereby minimizing its absorption into the bloodstream.

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Research

5 / 1000+ results

research Effects of a novel finasteride 0.25% topical solution on scalp and serum dihydrotestosterone in healthy men with androgenetic alopecia

42 citations , December 2015 in “International Journal of Clinical Pharmacology and Therapeutics”

This study found that applying a novel 0.25% finasteride solution to the scalp can effectively reduce scalp DHT levels in men with androgenetic alopecia, potentially reducing systemic side-effects.

research Faculty Opinions recommendation of Topical finasteride for the treatment of male androgenetic alopecia and female pattern hair loss: a review of the current literature.

December 2021 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Topical finasteride is promising for hair loss with minimal side effects but needs more research and approval.

research A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Women.

23 citations , April 2018 in “PubMed”

This review finds preliminary evidence suggesting that topical finasteride may significantly reduce hair loss and increase hair counts in treating androgenetic alopecia, with a promising safety profile.

research Formulation and In-vivo Assessment of Topical Polyherbal Hair Serum to Promote Hair Growth

December 2023 in “International journal of drug delivery technology”

In this study, researchers developed a polyherbal serum using extracts from various herbs and tested it on rats with testosterone-induced alopecia, observing it potentially promotes hair growth and decreases androgen-induced hair loss, with results compared to a positive control using finasteride.

research Efficacy and safety of topical combination of 3% minoxidil and 0.25% finasteride versus 3% minoxidil solution in female-pattern hair loss: A randomized, double-blind, controlled study

1 citations , August 2018 in “Journal of The American Academy of Dermatology”

Combination of minoxidil and finasteride is more effective in increasing hair diameter than minoxidil alone for female-pattern hair loss.

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Community Join

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community For people with overly oily hair, does topical finasteride/dutasteride/antiandrogens (like RU or Pyrilutamide) reduce sebum overproduction?

in Finasteride/Dutasteride 6 upvotes 3 years ago

The conversation discusses whether topical finasteride, dutasteride, or antiandrogens like RU58841 can reduce sebum overproduction as an early indicator of their effectiveness in treating hair loss. It suggests that while hair growth may take months to observe, a decrease in oiliness could be a quicker sign of a product's action.

community Hims topical min/fin spray vs serum

9 upvotes 2 years ago

The conversation is about someone switching from a hair loss treatment spray with alcohol and propylene glycol to a serum with essential oils, questioning the absorption and effectiveness of the new product. The spray and serum both contain 0.3% finasteride and 6% minoxidil.

community Diluting 0.05% topical finasteride serum/oil

1 upvotes 3 years ago

The user wants to reduce their dose of topical finasteride to 0.1-0.2mg and is considering mixing 0.2ml of their current finasteride + minoxidil serum with 0.8ml of a minoxidil-only serum for better scalp coverage. They are asking for advice on whether this method is effective or if there's a better way to dilute the finasteride solution.

community My case study: DHT serum levels unresponsive to higher topical fin dosages.

in Finasteride/Dutasteride 9 upvotes 2 years ago

The user has been using liposomal topical finasteride since late 2022, progressively increasing the dose, but DHT serum levels remain largely unchanged. Despite using finasteride, minoxidil, microneedling, and ketoconazole, hair condition has neither improved nor worsened.

community Using topical ghk-cu in face serum for scalp as an adjunct to fin and min.

2 upvotes 1 month ago

Using a face serum with 1% copper peptides (ghk-cu) on the scalp as an adjunct to finasteride and minoxidil for hair growth and scalp health. The user is unable to find a specific hair serum with ghk-cu locally.

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Learn

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learn Finasteride

Frontline, gold standard treatment for combatting androgenic alopecia

Are there really risks with topical finasteride? Reports on topical finasteride describe scalp irritation and dermatitis as the effects specific to it, and blood levels lower than the oral drug; whether systemic side effects are genuinely rarer has not been measured in a trial powered to answer it. Both forms are prescription-only and contraindicated around pregnancy.
Topical or oral? Choosing between pills and lotions according to your case. Topical finasteride offers localized treatment with fewer systemic side effects than oral finasteride.
Do you want finasteride to penetrate better? The ideal solvent to maximize its effect. Formulation sources describe propylene glycol and microemulsion vehicles as increasing how much topical finasteride crosses the skin, but better penetration has not been shown to mean better hair results, and it also raises systemic exposure. The vehicle and strength are decisions for a prescriber or compounding pharmacist.

learn Overview

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Epidermal Growth Factor

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Bicalutamide

Is topical bicalutamide a safer alternative to finasteride? There is no published human trial of topical bicalutamide for hair loss, and no licensed topical product exists, so it cannot be called safer than finasteride — or shown to work at all. Oral finasteride has decades of trial data with a documented side-effect profile, and topical finasteride has a phase III trial behind it.

learn Fluridil

How is Fluridil different from other DHT blockers like finasteride? Fluridil is a topical androgen-receptor blocker applied to the scalp, while finasteride is an oral 5-alpha-reductase inhibitor that lowers DHT throughout the body. Finasteride is FDA-approved and far better studied; Fluridil rests on one 43-man trial and is not licensed as a hair-loss medicine, so its long-term safety and effect size are unknown.

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