October 2019 in “International journal of research in dermatology” This case report describes two instances of hyper-pigmentation induced by prolonged misuse of Betnovate cream, where cessation and appropriate treatment led to significant improvement within 15 days.
February 2022 in “Cleveland Clinic Journal of Medicine” This case report observed hypertrichosis on the left forearm of an 80-year-old woman, possibly linked to her previous use of the topical steroid betamethasone butyrate propionate for dermatitis.
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June 2000 in “Journal of the American Academy of Dermatology” This study found that betamethasone valerate in a foam vehicle has comparable total coverage to traditional topical corticosteroid vehicles, despite less coverage per unit of foam.
January 2010 in “Annals of King Edward Medical University” This study concluded that combination therapy with 5% minoxidil and 0.05% betamethasone dipropionate cream was more effective for hair regrowth in alopecia areata than 5% minoxidil alone.
September 2025 in “Clinical Cosmetic and Investigational Dermatology” This study in Jordan found that topical corticosteroid use is common and often involves creams obtained without prescriptions, with only 61.3% of users aware of potential side effects, highlighting a need for better public education and regulation to prevent misuse.