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natural substance from Neem tree with medicinal and pesticidal properties
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5 / 19 resultslearn Platelet-Rich Plasma
growth factors taken from your blood and injected into your scalp to stimulate hair
learn HMI-115
much-hyped research compound targeting prolactin receptor in scalp
learn Exosomes
Microscopic delivery system that sends growth-promoting signals to hair follicles
learn Osteopontin
signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
Research
5 / 1000+ results
research Selective Follicular Targeting by Modification of the Particle Sizes
Medium-sized particles penetrate hair follicles better than smaller or larger ones, which could improve delivery of skin treatments.
research Machine Learning-Driven Optimization of Therapeutic Substance Composition for High-Hardness, Fast-Dissolving Microneedles for Androgenetic Alopecia Treatment
This study addresses the challenge of delivering platelet-rich plasma (PRP) for androgenetic alopecia (AGA) treatment by developing a machine-learning-driven strategy to optimize the composition of microneedles (MNs). The approach involves selecting therapeutic substances, conducting 18 orthogonal experiments, and using machine learning to identify an optimal material composition that achieves high hardness and rapid dissolution. The resulting MNs demonstrated sustained release of growth factors, over 90% bacterial inhibition, reactive oxygen species scavenging, and enhanced proliferation of dihydrotestosterone-damaged human dermal papilla cells. In vivo studies showed significant hair regrowth in AGA mice via the Wnt/β-catenin pathway, surpassing minoxidil's effects, while avoiding biosafety risks from synthetic materials. This framework could expedite the clinical translation of biomaterials like MNs.
research Progress in Pluronic F127 Derivatives for Application in Wound Healing and Repair
Pluronic F127-derived hydrogels show promise for effective wound healing and repair.
research Therapeutic Efficacy and Promise of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in Aging and Age-Related Disorders
Human umbilical cord stem cell vesicles may help treat aging and related diseases.
research Copper-Quercetin Complexes: Methods of Study, Relevance to Cell Death Pathways, Therapeutic Applications
Copper-quercetin complexes could be effective in treating cancer, infections, and promoting bone healing.
Community Join
5 / 202 results
community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens
Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.
community FCE 28260: A Forgotten 5α-Reductase Inhibitor
FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.
community The story of RU58841/ PSK3841
RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.
community Dutasteride thins eyebrows and facial hair but doesn't stop scalp loss.
Dutasteride may not effectively stop scalp hair loss and can cause thinning of facial and body hair, including eyebrows. Users suggest considering other causes like autoimmune conditions or vitamin deficiencies and exploring treatments like finasteride or minoxidil.
community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.
A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.