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Did you mean Dihydrotestosterone Synthesis?

Glossary Dihydrotestosterone Synthesis

enzyme 5-alpha-reductase converts testosterone into potent androgen DHT

Dihydrotestosterone (DHT) synthesis is the process by which the enzyme 5-alpha-reductase converts testosterone into DHT, a more potent androgen hormone. DHT plays a crucial role in the development of male characteristics and is also implicated in conditions like male pattern baldness and prostate enlargement.

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Research

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research Inhibition of Rat 5α-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract ofQuercus acutissimaCortex

37 citations , January 2015 in “Evidence-based Complementary and Alternative Medicine”

This study found that Bokusoku extract and its compound pentagalloyl glucose inhibited testosterone metabolism and sebum synthesis, suggesting potential therapeutic use for androgen-related acne.

research Synthesis and Actions of 5α-Reduced Metabolites of Testosterone in the Nervous System

1 citations , December 2021 in “Androgens”

This review discusses the effects of neuroactive testosterone metabolites on CNS functions and suggests their potential as therapeutic options for neurological disorders, but reports no new clinical results.

research Effect of Eurycoma longifolia Extract on Testosterone Synthesis in TM3 Leydig Cells under Oxidative Stress

1 citations , July 2022 in “Han'gug sigpum yeong'yang gwahag hoeji/Journal of the Korean society of food science and nutrition”

In this study, ELE was found to protect against oxidative stress-induced testosterone reduction in TM3 Leydig cells by increasing testosterone synthesis and decreasing its conversion.

research Novel progestogenic androgens for male contraception: design, synthesis, and activity of C7 α-substituted testosterone

September 2023 in “Biology of reproduction”

This study suggests that the testosterone analogs 7α-Methyltestosterone and 7α-Ethyltestosterone may offer promising androgenic, progestogenic, and anabolic properties for development as male contraceptives.

research 013 Prostaglandin D2 enhances testosterone metabolism by ROS-mediated altered redox potential in keratinocytes

September 2017 in “Journal of Investigative Dermatology Symposium Proceedings”

This study found that prostaglandin D2 increases testosterone production in human keratinocytes through a mechanism involving ROS and REDOX potential, which could inform treatments for androgenic alopecia.

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Community Join

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community Ray Peat: Testosterone Isn’t the Culprit, Prolactin and Cortisol Drive Hair Loss (2016)

in Research/Science 110 upvotes 11 months ago

Prolactin and cortisol are identified as key factors in hair loss, with stress hormones impacting hair shedding. Finasteride and minoxidil are effective treatments, while DHT's role and individual sensitivity are significant factors.

community Finasteride In my 30s for 8 years. Off it till 50 years old. Now on testosterone.

in Finasteride/Dutasteride 129 upvotes 5 months ago

A user shared their experience of using finasteride for hair loss from ages 29 to 37, stopping due to side effects like low libido, and later starting testosterone therapy, which improved their well-being. The discussion includes various opinions on the effects of finasteride and testosterone on hair loss, libido, and overall health, with some users questioning the correlation between finasteride and low testosterone.

community For people that keep saying Breezula is weaker than fin...

6 upvotes 6 years ago

Breezula protects hair follicles from both testosterone and DHT, unlike finasteride, which only protects against DHT. This could potentially lead to significant hair regrowth, similar to results seen in transgender individuals using hormone blockers.

community Is this broscience? From More Plates, More Dates

in Research/Science 21 upvotes 2 years ago

The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

community Increased adipose tissue (being overweight) in males may increase likelyhood of finasterde side effects

in Research/Science 29 upvotes 2 years ago

Being overweight may increase finasteride side effects due to higher aromatase activity converting testosterone to estradiol. Maintaining a healthy weight could reduce these side effects.

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Learn

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learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Finasteride

Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically

learn Bicalutamide

Could bicalutamide help trans women regrow hair lost to testosterone? No study has tested bicalutamide for hair regrowth in trans women. In cisgender women the only randomized trial found it added nothing to minoxidil, and it is an off-label prescription drug that requires liver monitoring.

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Clinics

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Colour Synthesis Paramedical Camouflage Tattoo StudioCenturion · ZA

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