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research Successful treatment with hydroxychloroquine for systemic lupus erythematosus with cutaneous involvement accompanied by a xanthomatous reaction

3 citations , December 2019 in “Lupus”

In this report, researchers describe a case of scalp discoid lupus erythematosus unresponsive to topical treatments, where hydroxychloroquine administered at 200 mg/day led to complete resolution of skin lesions in five months.

research Adverse Systemic Reaction to Dinitrochlorobenzene

14 citations , June 1982 in “Archives of Dermatology”

This letter to the editor shares concerns about possible systemic effects from topical dinitrochlorobenzene therapy in a 25-year-old man treating alopecia areata.

Hair Loss After Drug Reaction With Eosinophilia and Systemic Symptoms: A Multicentric Retrospective Case Series

research Hair loss after drug reaction with eosinophilia and systemic symptoms (DRESS): A multicentric retrospective case series

2 citations , January 2023 in “Journal of Dermatology”

This study reports that various types of alopecia, including permanent alopecia, can persist after an acute DRESS episode, but telogen effluvium and alopecia areata showed clinical improvement with treatment within six months.

research Six-year Retrospective Review of Drug Reaction with Eosinophilia and Systemic Symptoms

39 citations , January 2012 in “Acta dermato-venereologica”

This study examined 27 DRESS patients diagnosed in Thailand, identifying phenytoin, allopurinol, and nevirapine as common causes, with a 3.7% mortality rate and systemic corticosteroids being a common treatment.

research Drug reaction with eosinophilia and systemic symptoms and severe involvement of digestive tract: description of two cases

19 citations , June 2011 in “British Journal of Dermatology”

Severe digestive issues in DRESS need early endoscopy for better treatment.

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community If PP405 goes systemic this would be quite catastrophic

in Research/Science 4 upvotes 1 year ago

Concerns about the potential systemic effects and safety of PP405 for hair loss, with discussions on its comparison to existing treatments like finasteride and minoxidil. Users express skepticism about untested research chemicals and emphasize the importance of clinical trials to ensure safety and efficacy.

community How finasteride lowers brain's happiness steroid allopregnanolone and causes depression: systemic dihydroprogesterone crosses blood brain barrier, you don't even need finasteride and brain 5ar for that

288 upvotes 1 year ago

Finasteride may lower allopregnanolone levels, potentially affecting mood, but many users report improved mental health due to reduced hair loss. Experiences with finasteride and dutasteride vary, with some experiencing side effects and others finding them beneficial for hair retention and overall happiness.

community Can i apply minoxidil to other areas of my body to work on my scalp (ie does it go systemic enough?)

10 upvotes 3 days ago

Minoxidil should be applied directly to the scalp for effectiveness, as applying it elsewhere may not work and could cause systemic effects. Alternatives like oral minoxidil are not suitable for everyone due to potential side effects like severe water retention.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 140 upvotes 2 years ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community Long-term use of dutasteride may lead to male infertility by persistently impairing semen volume and sperm motility.

in Finasteride/Dutasteride 87 upvotes 1 year ago

Long-term use of dutasteride may impair semen volume and sperm motility, but these effects are often reversible after stopping the drug. Individual reactions vary, and more research is needed to understand the long-term impact on fertility.

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learn Latanoprost

What are the possible side effects of using latanoprost on the scalp? No study has measured the side effects of latanoprost on the scalp. The reactions listed here are extrapolated from the eye-drop label — irritation, burning, itching and skin darkening — plus the systemic reactions the label records at ophthalmic doses; absorption over a whole scalp has never been measured.

learn Vascular Endothelial Growth Factor

learn Epidermal Growth Factor

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn sh-Polypeptide-7

learn Overview

learn Follistatin

Can follistatin be applied topically, or is it only effective through injections or systemic use? Follistatin is not effective when applied topically and requires injections or systemic use.

learn Thymosin Beta 4

Is Thymosin Beta 4 being explored more as a topical treatment or as a systemic (oral or injectable) approach for hair loss? Thymosin Beta 4 is primarily being explored as a topical treatment for hair loss.

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