Effect of Topically Applied Minoxidil on the Survival of Rat Dorsal Skin Flap

September 2012 in “ Aesthetic Plastic Surgery ”

Nazım Gümüş, Yusuf Ödemiş, Sarper Yilmaz, Ersin Tuncer

minoxidil angiogenesis vasodilation dorsal skin flap preoperative application postoperative application Rogaine

TLDR Minoxidil applied before and after surgery improves skin flap survival in rats.

In a 2012 study involving 24 male Wistar rats, researchers found that preoperative application of minoxidil for 7 days followed by postoperative application for another 7 days significantly improved the survival of caudally based dorsal rat skin flaps. Group 3, which received this treatment regimen, showed a significantly higher flap survival rate and increased angiogenesis compared to the control group and the group that received minoxidil only postoperatively. The study concluded that minoxidil promotes flap viability through vasodilation and angiogenesis when applied in a timely manner before and after flap elevation. No systemic reactions to minoxidil were observed in the rats.

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Research cited in this study

7 / 7 results

research Topically Applied Minoxidil May Cause Fetal Malformation: A Case Report

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Minoxidil stimulates hair growth by increasing hair thickness and prolonging growth phase.

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research Minoxidil: A Review of Its Pharmacological Properties and Therapeutic Use

96 citations, October 1981 in “Drugs”

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research The Effect of Topical Minoxidil Pretreatment on Nonsurgical Delay of Rat Cutaneous Flaps: Further Studies

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research Effect of Topically Applied Minoxidil on the Survival of Rat Dorsal Skin Flap

6 citations, September 2012 in “Aesthetic Plastic Surgery”

Minoxidil applied before and after surgery improves skin flap survival in rats.

Effect of Topically Applied Minoxidil on the Survival of Rat Dorsal Skin Flap

Research cited in this study

research Topically Applied Minoxidil May Cause Fetal Malformation: A Case Report

research Angiogenesis and Minoxidil

research The Therapeutic Use of Topical Minoxidil

research Topical Minoxidil: Cardiac Effects in Bald Men

research Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action

research Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography

research Minoxidil: A Review of Its Pharmacological Properties and Therapeutic Use

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