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research Neuronal plasticity of the “brain–skin connection”: stress-triggered up-regulation of neuropeptides in dorsal root ganglia and skin via nerve growth factor-dependent pathways

66 citations , July 2007 in “Journal of Molecular Medicine”

This study in mice demonstrated that stress or nerve growth factor injection increases sensory neuron activity related to skin innervation, suggesting a strong connection between stress perception and neurogenic skin inflammation.

research The impact of air pollution on skin and related disorders: A comprehensive review

98 citations , February 2021 in “Dermatologic Therapy”

This review explores how air pollutants may contribute to various skin diseases and highlights potential mechanisms, but it presents no new clinical findings.

research Network pharmacology and in vivo experimental analysis for validating the antifibrotic potential of Punica granatum leaves against skin scleroderma: the role of oxidative stress, inflammation and TGF-β1/Snail 1/p-Smad 3 signaling pathway

April 2026 in “Inflammopharmacology”

This study found that Punica granatum ethanolic leaf extract may alleviate skin fibrosis in rats by modulating inflammation-related pathways and reducing dermal alterations.

research The Gut-Brain-Skin Axis and Role of Intestinal Dysbiosis in Acne Vulgaris: Therapeutic Effects of Pro- and Prebiotic Use

2 citations , January 2018 in “Elsevier eBooks”

This review discusses the complex mechanisms behind acne vulgaris and suggests that dietary modification, along with pro- and prebiotics, may influence its pathogenesis by addressing stress-induced skin inflammation.

research Adaptogenic herbal extracts for stress-induced dermatoses: a narrative review

July 2026 in “Archives of Dermatological Research”

This study explores the potential of adaptogenic herbal extracts like ashwagandha, rhodiola, and schisandra in treating stress-induced dermatoses, noting their effects on modulating the HPA axis, reducing inflammation, and improving skin barrier function.

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community The Role of Astaxanthin as a Nutraceutical in Health, Age-Related Conditions and Hair Loss

3 upvotes 3 years ago

Astaxanthin (ASX) is highlighted as a promising supplement for treating hair loss due to its antioxidant properties. It may help with inflammation and oxidative stress, which are linked to hair loss and aging.

community Does anyone know the chemical formula for pelage pp405?

15 upvotes 1 year ago

The conversation discusses the lack of public information on the chemical structure of PP405, a hair loss treatment, and the challenges of synthesizing it without a patent. It also explores a patent related to hydrogen-based topical formulations for reducing oxidative stress and inflammation.

community Has anyone tried nicotinamide serum for inflammatory hair loss.

3 upvotes 1 year ago

Nicotinamide serum is discussed for its potential benefits in reducing inflammation related to hair loss. One user combines it with minoxidil for hair growth.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

63 upvotes 2 years ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community Keratin microspheres - breakthrough

14 upvotes 2 years ago

A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

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