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research Age-related changes in endogenous glucocorticoids, gonadal steroids, endocannabinoids and their ratios in plasma and hair from the male C57BL/6 mice

11 citations , October 2020 in “General and comparative endocrinology”

This study found that age-related fluctuations in hormones and endocannabinoids in male C57BL/6 mice showed specific patterns, with peak values observed around 2.7 to 3.4 months, with these patterns seen in both plasma and hair but with different magnitudes.

research Age-related hair changes in men: Mechanisms and management of alopecia and graying

37 citations , October 2014 in “Maturitas”

This review discusses the mechanisms and treatment strategies for age-related hair changes, such as androgenetic alopecia and hair graying, and reports no new clinical results.

research Children’s hair cortisol and hair testosterone concentrations in response to environmental changes: from summer holidays to school

3 citations , November 2021 in “Stress”

This study found that school-related stress increases hair cortisol in girls and alters hair testosterone and cortisol levels in boys, indicating gender-specific hormonal responses to environmental changes.

research Decision letter: Quantitative mapping of human hair greying and reversal in relation to life stress

April 2021

This study found that some white or grey hairs can naturally regain pigmentation, suggesting hair greying may be reversible in certain conditions linked to psychological stress.

research The systemic wrinkled skin phenotype involves aberrant expression and variation of genes related to the oxidative stress and extracellular matrix in Xiang pigs

November 2025 in “BMC Genomics”

This study found that the systemic wrinkled skin phenotype in Xiang pigs involves gene expression changes and genetic variations associated with oxidative stress and extracellular matrix components, resembling features seen in Shar-Pei dogs.

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Community Join

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community How the hell am I still losing hair

in Finasteride/Dutasteride 8 upvotes 1 year ago

The user has been experiencing sudden and aggressive hair shedding despite using oral dutasteride and topical minoxidil for six years, and recently added topical finasteride without improvement. Possible causes discussed include stress-related hair loss, dietary changes, or high DHT sensitivity, with suggestions to consult a doctor and consider adjusting treatments.

community Could organic oils help out my old mom with her thinning hair?

1 upvotes 3 months ago

The conversation discusses hair thinning in an older woman, suggesting that organic oils like rosemary or argan oil are unlikely to help if the hair loss is due to stress or hormonal changes. It highlights that hair loss in older women is often related to hormonal changes during menopause.

community Diet changes w Alopecia areata.

5 upvotes 6 days ago

The conversation discusses alopecia areata and whether diet changes can resolve it. One user mentions that their condition fluctuates without dietary changes, suggesting stress as a possible factor.

community Need Help Please! It's about Exosome therapy and my hair fall. If you have any questions, feel free to ask!

in Treatment 1 upvotes 6 months ago

A person experienced hair loss due to stress, hormonal changes, and possibly genetics, and tried treatments like minoxidil, finasteride, and dutasteride. They are now considering exosome therapy but are unsure about its effectiveness and which dermatologist to trust.

community The ending of alopecia? Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence

63 upvotes 4 years ago

Corticosterone inhibits GAS6, affecting hair follicle stem-cell activity, with potential implications for stress-related hair loss. Ashwagandha and Vitamin K are suggested for reducing cortisol, but their effectiveness is debated.

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Learn

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learn Overview

learn Epidermal Growth Factor

learn Vitamin B5

Is Vitamin B5 beneficial for people experiencing stress-related or nutritional hair loss? Vitamin B5 is not proven to help with stress-related or nutritional hair loss.

learn Vitamin B6

Is Vitamin B6 helpful for stress-related or hormonal hair loss? Vitamin B6 may support overall health but lacks strong evidence for preventing hair loss.

learn Lavender

Is lavender effective for hormonal hair loss or just stress? Lavender may help with stress-related hair loss but has limited evidence for hormonal hair loss.

learn Hair Transplant

How can I stop hair loss related to hair transplants? Adopt a nutritious diet, manage stress, and consult a specialist for tailored treatments.

learn PP405

Got small bald patches they say are from stress? PP405 sprays could help bring them back to life. PP405 is an experimental topical gel from Pelage Pharmaceuticals that inhibits the mitochondrial pyruvate carrier; its registered Phase 2 trial (NCT06393452) tested it once daily in 78 adults with pattern hair loss, for safety and tolerability. It is not approved, not for sale, and has not been studied in alopecia areata or stress-related shedding.

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Clinics

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