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learn Spironolactone

powerful topical and oral anti-androgen used mostly by women

How does spironolactone help reduce hair loss when used in topical or oral treatments? Studies report that spironolactone slows androgen-driven follicle miniaturisation by blocking androgen receptors, with most evidence in women and mostly alongside minoxidil; it is a prescription drug and its use for hair loss is off-label.
Is spironolactone better for hair regrowth as a pill or as a scalp solution? Oral spironolactone has the stronger published evidence for hair regrowth; topical versions cause fewer systemic side effects but have been studied far less, and no trial has compared the two head to head.
Who can safely use spironolactone for hair thinning and androgen-related hair loss? Women with androgen-related hair loss can safely use spironolactone under medical supervision.
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Community Join

5 / 363 results

community anybody here having success with Topical Spironolactone?

4 upvotes 3 years ago

The user plans to mix Kirkland minoxidil with spironolactone tablets for hair loss. They cannot use finasteride, saw palmetto, or spearmint tea due to side effects like insomnia and low testosterone.

community Spironolactone to stop hair shedding

4 upvotes 3 years ago

A doctor suggested spironolactone for hair shedding, but concerns were raised about its effectiveness and side effects compared to finasteride. The user plans to reduce testosterone dosage and start finasteride instead.

community Any male on topical spironolactone?

in Research/Science 7 upvotes 9 months ago

Topical spironolactone is discussed for hair loss treatment, with mentions of DIY solutions and dermatologist compounding. Users inquire about regrowth and sourcing the treatment.

community Topical spironolactone — how many ml do you apply?

6 upvotes 1 year ago

The conversation discusses the use of topical spironolactone for hair loss, with the original poster applying 8 ml daily but learning that 2 ml is recommended. It also touches on hair transplants and the role of DHT sensitivity in hair loss, emphasizing individual differences in treatment outcomes.

community Going from ingesting topical minoxidil to oral tablets?

9 upvotes 2 months ago

A user is considering switching from topical minoxidil to oral tablets due to cost and convenience, but is concerned about dosage differences and potential hair loss. They have been ingesting minoxidil residue from their fingers, leading to unwanted body hair growth, and are also taking dutasteride.

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Research

5 / 1000+ results

research USE OF SPIRONOLACTONE IN COMBINATION WITH AN ORAL CONTRACEPTIVE IN TREATMENT OF HIRSUTISM

January 2004

This study found that a combination of spironolactone and oral contraceptive pills may improve hirsutism and hormonal profiles in women, although some experienced side effects such as persistent nausea.

research Spironolactone for the Treatment of Acne: A 4-Year Retrospective Study

22 citations , January 2017 in “Dermatology”

In this retrospective study, spironolactone improved acne in 86% of patients while showing minimal side effects, suggesting it as a safe treatment option for postadolescent acne with a low risk of short-term adverse effects like hyperkalemia.

research High-dose spironolactone for acne in patients with polycystic ovarian syndrome: A single-institution retrospective study

3 citations , August 2019 in “Journal of The American Academy of Dermatology”

This report shares the authors' experience using spironolactone for treating acne in a PCOS clinic, but provides no new clinical results.

research Follicular delivery of spironolactone via nanostructured lipid carriers for management of alopecia

89 citations , November 2014 in “International Journal of Nanomedicine”

This study suggests that spironolactone-loaded nanostructured lipid carriers could enhance follicular delivery and offer a more localized treatment for androgenic alopecia, potentially reducing systemic side effects.

research Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone

80 citations , December 2017 in “International Journal of Dermatology”

This study reported that once-daily treatment with oral minoxidil and spironolactone for 12 months reduced hair loss severity and hair shedding in women with pattern hair loss, with generally mild side effects, though results came from an uncontrolled, observational pilot study.

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