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Research

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research Skin-specific expression of a truncated E1a oncoprotein binding to p105-Rb leads to abnormal hair follicle maturation without increased epidermal proliferation.

30 citations , June 1993 in “The Journal of Cell Biology”

This study found that transgenic mice expressing a mutant E1a oncoprotein in their skin had disturbed hair follicle maturation but did not show increased tumor development or proliferation.

research Endocannabinoids limit excessive mast cell maturation and activation in human skin

124 citations , January 2012 in “Journal of Allergy and Clinical Immunology”

This study found that activation of cannabinoid 1 receptors in human scalp hair follicles may limit excessive mast cell activation and maturation, suggesting a potential therapeutic strategy for managing MC-dependent skin diseases.

research Sorafenib stimulates human skin type mast cell degranulation and maturation

7 citations , August 2017 in “Journal of dermatological science”

This study found that sorafenib increased mast cell number and degranulation in skin, suggesting PI3K signaling and SCF production may underlie its adverse cutaneous reactions.

research Mechanisms of skin vascular maturation and maintenance captured by longitudinal imaging of live mice

29 citations , May 2023 in “Cell”

research Mechanisms of vascular maturation and maintenance captured by longitudinal imaging of live mouse skin

November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

In this study, researchers observed that blood vessel maturation in mice involves neonatal endothelial cells expanding the capillary network through vessel regression and angiogenesis, with adult cells later maintaining stability and repair through specific signaling pathways.

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Community Join

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community 18m 2.5 mg dut + topical min + 5 mg injectable ghk-cu progress. caught agressive loss early seemingly. may i have a few more years of handsomeness upon me.

in Is this regrowth? 24 upvotes 1 year ago

An 18-year-old is using a high-dose treatment for hair loss, including 2.5 mg dutasteride, topical minoxidil, and injectable GHK-Cu, despite minimal hair loss. Many users suggest reducing the dutasteride dose due to potential side effects and recommend starting with finasteride instead.

community Why everyone should be using topical Dutasteride

45 upvotes 3 months ago

Topical Dutasteride, especially in a liposomal base, is recommended for enhanced scalp DHT suppression when used with oral Dutasteride. It is suggested to apply it twice a week for effective results without significant systemic impact.

community Massaging scalp, day 163, Update. NEED ADVICE!!

in Chat 4 upvotes 6 months ago

The conversation discusses hair loss treatments, including scalp massage, and the importance of blocking DHT for hair loss management. The user shares blood test results, which appear normal, and seeks advice on effective tests and treatments, expressing a preference for natural methods over medication.

community 1.5 years topical minox 0.5 ml twice (just temples) + 0.5 mg oral finasteride daily.

in Progress Pictures 664 upvotes 11 months ago

The user experienced hair regrowth and improved hair quality using topical minoxidil on temples and oral finasteride daily. They also noted thicker eyebrows and some side effects like minor erectile dysfunction.

community After quitting min and fin I asked AI on how fix the mess I am in and it says:

in Technology 1 year ago

Prolonged use of topical minoxidil and finasteride can lead to neuroendocrine and autonomic dysfunction, causing severe sensitivity and side effects. Recovery involves avoiding these treatments, supporting neurosteroid recovery, calming the sympathetic system, and rebuilding scalp health naturally.

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Learn

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learn Melatonin

Can melatonin cause side effects on the skin or hair? Melatonin may cause hair loss or thinning in some users, but evidence is limited.

learn Scalp Micropigmentation

Does scalp micropigmentation work on all skin tones and hair colors? Scalp micropigmentation can be customized for various skin tones and hair colors.
Is scalp micropigmentation suitable for people with sensitive skin? Providers say scalp micropigmentation suits most skin types and describe patch tests, hypoallergenic pigments and a skin consultation for sensitive skin. These are provider claims rather than independent safety evidence, and pigment reactions remain a risk.

learn retinol

How does retinol improve scalp health and prepare the skin for other hair growth treatments? Retinol improves scalp health by promoting cellular turnover and reducing congestion.

learn Hyaluronic Acid

Does hyaluronic acid really hydrate the scalp, or is it mainly for skin care? Hyaluronic acid can hydrate the scalp, but its effectiveness may vary.

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Clinics

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Experts

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35
SMP Specialist
Noelle Skin
Nice, France

Noelle Skin