7 citations
,
February 2022 in “Stem cell reviews and reports”
This review discusses the heterogeneity and plasticity of epithelial stem cells in skin homeostasis, wound healing, and tumorigenesis, reporting no new results but emphasizing the need for further exploration of key regulatory mechanisms.
3 citations
,
October 2023 in “Military Medical Research/Military medical research”
This review explores the crucial role of regulatory T cells in skinwound healing, emphasizing their involvement in balancing immune responses and promoting regeneration. It also discusses Tregs' operations in fibrosis, keloidosis, and scarring, suggesting a potential avenue for novel treatments.
The user has been using minoxidil and finasteride for hair loss but is now considering microneedling due to recent hairline regression. Another user reassures that derma rolling causes only slight redness, which usually heals overnight.
Oral minoxidil is effective for hair loss and unlikely to significantly affect collagen synthesis, making it a safe option without causing premature skin aging. Users report positive hair regrowth without noticeable skin aging.
Exploring a potential hair loss treatment using the enzyme AKR1C2 to locally reduce DHT levels. Challenges include enzyme delivery through the skin and high production costs, with gene therapy or stem cells suggested as future alternatives.
Verteporfin, combined with microneedling, shows promise for hair regrowth by allowing hair follicles to grow in wounds, but it's expensive and painful. Pai-1 inhibitors may also help prevent hair loss by degrading fibrosis, and some users continue using minoxidil alongside these treatments.
Minoxidil is unlikely to cause skin aging at typical doses, and concerns about collagen inhibition are mostly unfounded. Users suggest using sunscreen and tretinoin for skin health, and some combine minoxidil with finasteride for hair maintenance.
What microneedling is?Microneedling uses fine needles to make tiny skin wounds that trigger healing. Some devices are FDA-authorized for acne scars; none is authorized for hair loss, where evidence comes mainly from small studies.
What is GHK-Cu and why is it said to be a "miracle" for hair?GHK-Cu is a copper peptide studied mainly for wound healing and skin repair; for hair loss the evidence stops at cell-culture and animal work, and no published human trial has tested it for androgenetic alopecia.
Can follistatin be applied to the skin, and does any form of it treat hair loss?No study shows that follistatin applied to the skin works, and no form of follistatin is an approved or proven hair-loss treatment. Follistatin injections, "research peptides" and gene therapies sold outside regulated trials are unapproved and of unknown safety.
Is scalp micropigmentation safe?Providers describe scalp micropigmentation as low-risk when a trained practitioner uses sterile single-use equipment, but that is a provider claim rather than a regulatory finding: pigment allergy, infection and colour change are documented risks of cosmetic tattooing.