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research The SH-1 Molecule By Dr. Melvin Sewell

June 2026 in “HAL (Le Centre pour la Communication Scientifique Directe)”

This article presents the SH-1 molecule as a novel AR antagonist for androgenetic alopecia treatment, highlighting its tissue-specific action and potential for commercialization, but provides no new clinical results.

research The SH-1 Molecule By Dr. Melvin Sewell

June 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

This source describes SH‑1 as a next-generation androgen receptor antagonist designed for localized treatment of androgenetic alopecia, aiming to reverse follicular miniaturization while maintaining endocrine balance. Unlike traditional therapies, SH‑1 offers tissue-specific action, avoiding systemic effects.

research Therapeutic Potential of Secretome from Hypoxic-Mesenchymal Stem Cell (SH-MSC) in Regulating PDGF and IL-1β Gene Expression in Fluconazole-Related Alopecia

April 2024 in “Biosaintifika Journal of Biology & Biology Education”

In this study, secretomes from hypoxic mesenchymal stem cells were found to increase PDGF and reduce IL-1β gene expression in rats, potentially offering an effective topical treatment for alopecia caused by long-term fluconazole use.

research Effect of Topical Gel Administration of Secretome Hypoxia Mesenchymal Stem Cells (SH-MSCs) on IL-10 and TNF- α Gene Expression (In Vivo Experimental Study in Male Rats of Wistar Strains Model of Fluconazole-Induced Alopecia)

December 2023 in “International journal of multidisciplinary research and analysis”

In this study, topical administration of secretome hypoxia mesenchymal stem cells gel increased IL-10 and decreased TNF-α gene expression in a fluconazole-induced alopecia-like model in rats, with the 40 μL dose having the most significant effect.

research What’s Sex Got to Do With COVID-19? Gender-Based Differences in the Host Immune Response to Coronaviruses

125 citations , August 2020 in “Frontiers in Immunology”

This review discusses sex-based differences in immune responses, focusing on genetic, hormonal, and microbiome factors influencing infections like COVID-19, and reports no clinical results.

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learn Epidermal Growth Factor

learn sh-Polypeptide-7

Does sh-Polypeptide-7 stimulate hair follicles or reduce scalp inflammation? sh-Polypeptide-7 is the INCI name for a lab-made form of human growth hormone (somatotropin) — not EGF, which is sh-Oligopeptide-1. Growth hormone and IGF-1 signalling is documented in hair follicle biology, but there is no published human trial of sh-Polypeptide-7 applied to the scalp for hair growth or scalp inflammation.
What is sh-Polypeptide-7 and why is it used in some advanced hair serums and treatments? sh-Polypeptide-7 is the cosmetic-ingredient name for recombinant human growth hormone. It is marketed in hair and scalp products, but no published human trial shows that it helps hair growth, and its safety on the scalp has not been studied.
Is sh-Polypeptide-7 considered a natural or synthetic ingredient, and how is it typically applied? sh-Polypeptide-7 is a synthetic (lab-made) form of human growth hormone, used in some topical skin and hair-care products. There is no published human trial showing that it benefits hair, and its safety on the scalp has not been studied.
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learn Follistatin

Protein that blocks activin, a growth-regulating signal

learn Stem Cell Factor

learn Thymosin Beta 4

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Community Join

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community Balding at the age of 17 years old

14 upvotes 2 years ago

A 17-year-old experiencing hair loss is using Minoxidil but is hesitant about Finasteride due to potential side effects. Others recommend Finasteride for its effectiveness and suggest alternatives like vitamins and derma rollers.

community We Are So Back. 10 Months Difference

1212 upvotes 11 months ago

The user experienced significant hair regrowth over 10 months by using 1.5mg oral finasteride and minoxidil daily, along with weekly derma stamping, after a previous hair transplant and initial thinning. The conversation highlights the importance of using DHT blockers post-transplant to maintain results.

community In search of help and advices (18M)

in General 147 upvotes 1 year ago

An 18-year-old is experiencing hair thinning and considering treatments like scalp massages, vitamin D supplements, Minoxidil, and dermarolling to improve hair density while maintaining blonde hair. They are concerned about potential hair darkening from Minoxidil and seek advice on preserving their hair color and health.

community Found a Pharmacy that will mix me 0.1 % Alfatradiol (Pantostin)

in Treatment 6 upvotes 2 years ago

The user is currently using 0.025% Pantostin but plans to switch to 0.1% Alfatradiol. They will also use high-dose Kx826, high-dose Minoxidil, and aggressive microneedling for hair regrowth.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 140 upvotes 2 years ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

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