Therapeutic Potential of Secretome from Hypoxic Mesenchymal Stem Cells in Regulating PDGF and IL-1β Gene Expression in Fluconazole-Related Alopecia
April 2024
in “
Biosaintifika Journal of Biology & Biology Education
”
Studysummary In this study, secretomes from hypoxic mesenchymal stem cells were found to increase PDGF and reduce IL-1β gene expression in rats, potentially offering an effective topical treatment for alopecia caused by long-term fluconazole use.
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The study investigates the therapeutic potential of secretomes from hypoxic mesenchymal stem cells (SH-MSCs) in treating fluconazole-related alopecia. Fluconazole therapy can cause severe alopecia by increasing IL-1β and decreasing PDGF. The experiment involved 6 rats per group, with groups receiving either a placebo or topical gel containing 10% or 20% SH-MSCs. Results showed that SH-MSC application significantly increased PDGF and decreased IL-1β gene expression, with the highest PDGF expression and lowest IL-1β expression observed in the group treated with 20% SH-MSCs. Histopathological analysis confirmed improved hair follicle tissue, suggesting SH-MSCs could be developed as a topical treatment for this type of alopecia.
