July 2014 in “Zenodo (CERN European Organization for Nuclear Research)” This study observed that low levels of calcium and magnesium in blood serum were associated with health issues like hair loss and anxiety among participants from urban and rural Pakistan.
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April 2007 in “Journal of Agricultural and Food Chemistry” This study found that apple polyphenol extract, particularly oligomeric procyanidins, inhibited pancreatic lipase activity and reduced triglyceride absorption in both mice and humans.
January 2026 in “International Journal of Pharmaceutical Quality Assurance” In this study, researchers observed that patients with Alopecia Areata had significantly lower serum zinc and higher copper levels compared to healthy controls, indicating a disrupted zinc-copper balance that may contribute to the disease's pathogenesis.
This study found a correlation between zinc levels in hair and serum, and alkaline phosphatase activity in acne phlegmonosa and alopecia areata patients.
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May 2019 in “Journal of pharmaceutical sciences” This study found that diffusion coefficients of chemicals in artificial sebum are significantly higher than those in stratum corneum lipids, suggesting the hair follicle may significantly contribute to transdermal permeation.