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Glossary Serine Protease

enzyme that breaks down proteins by cleaving peptide bonds

Serine proteases, also known as serine endopeptidases, are a group of enzymes that break down proteins by cleaving peptide bonds. They are named for the serine residue in their active site, which plays a crucial role in the catalytic process. These enzymes are involved in various biological processes, including digestion, immune response, and blood coagulation.

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research Keratinocyte-Specific Onset of Serine Protease BSSP Expression in Experimental Carcinogenesis

26 citations , September 2001 in “Journal of Investigative Dermatology”

This study found that the serine protease BSSP is strongly expressed in mouse skin during carcinogenesis and is upregulated independently of c-Fos and unaffected by glucocorticoids.

research A Novel Serine Protease Overexpressed in the Hair Follicles of Nude Mice

32 citations , May 1999 in “Biochemical and Biophysical Research Communications”

This study found that the gene BSSP, a serine protease, is predominantly expressed in sebaceous glands and is overexpressed in nude mouse skin.

research Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment

182 citations , May 2003 in “Development”

This study found that Myc activation in mouse epidermis impairs keratinocyte adhesion and motility by downregulating extracellular matrix and cytoskeleton proteins, affecting hair lineage differentiation.

research Miz1 is required for hair follicle structure and hair morphogenesis

33 citations , July 2007 in “Journal of cell science”

This study found that knocking out the transactivation domain of Miz1 in mouse keratinocytes disrupted hair follicle orientation, caused irregular pigmentation, and increased keratinocyte proliferation, indicating Miz1's role in hair follicle development and morphogenesis.

research Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis

65 citations , November 2013 in “The EMBO Journal”

HDAC1 is crucial for skin development and preventing tumors.

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