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research The Senescence–Stemness Alliance – A Cancer-Hijacked Regeneration Principle

68 citations , September 2018 in “Trends in Cell Biology”

This review discusses the senescence–stemness connection in cellular biology and reports no new findings, highlighting implications for both tissue repair and aggressive cancer behavior.

research Editorial: Hair Follicle Stem Cell Regeneration in Aging

4 citations , November 2021 in “Frontiers in Cell and Developmental Biology”

Aging causes hair loss and graying due to stem cell decline and changes in cell behavior and communication.

research The senescence-like activity of BMS-470539 is associated with anti-fibrotic actions in models of dermal fibrosis

September 2025 in “Arthritis Research & Therapy”

In this study, researchers found that the compound BMS-470539 induced a senescence-like state in fibroblasts from systemic sclerosis patients, reducing fibrosis-associated markers in vitro and decreasing skin thickness in a mouse model of skin fibrosis, suggesting a novel therapeutic strategy for managing fibroblast-driven diseases.

research 1430 Modeling the onset of senescence associated secretory phenotype predicts therapeutic targets

April 2018 in “Journal of Investigative Dermatology”

This study found that inhibiting NF-κB Essential Modulator (NEMO) in senescent murine dermal fibroblasts successfully reduced key factors associated with the senescence associated secretory phenotype (SASP), highlighting its potential as a therapeutic target for aging-related diseases.

research 316 Specialized ribosomes in human dermal fibroblast senescence

September 2019 in “Journal of Investigative Dermatology”

This study suggests that subtle modifications in ribosomal RNA methylation may influence cellular physiology and contribute to ribosome specialization in senescent human dermal fibroblasts.

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community Cell senescence-targeted treatment for hair loss, has anyone tried any products/enzymes etc. that use this theory

5 upvotes 1 year ago

DHT causes hair loss by driving cells into senescence, and a polyphenol in black chokeberry may reverse this. A product using this theory is being considered for use alongside finasteride, minoxidil, and microneedling.

community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.

44 upvotes 1 year ago

ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.

community Anti-oxidants that reverse hairloss?

86 upvotes 5 years ago

Resveratrol and fisetin, found in red wine and strawberries, may promote hair growth by affecting hair follicle cells. Users discuss various treatments, including natural remedies like saw palmetto and topical applications, with mixed opinions on their effectiveness compared to pharmaceuticals like finasteride.

community Evolution theory: AGA is your body trying to reduce the risk of prostate cancer by exposing your scalp to more UV

in Research/Science 9 months ago

Androgenic alopecia (AGA) might have evolved to reduce prostate cancer risk by increasing UV exposure to the scalp, but this theory is debated. Treatments like minoxidil and finasteride are used for AGA, though the exact causes and evolutionary reasons for hair loss are unclear.

community 25 years on Finasteride and it's not working anymore.

324 upvotes 6 months ago

A 47-year-old has been using finasteride for 25 years for hair loss, but it's less effective now. Suggestions include switching to dutasteride, stopping anastrozole, and trying minoxidil, microneedling, and possibly TRT.

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