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    Did you mean Senescence-Associated Secretory Phenotype?
    Glossary Senescence-Associated Secretory Phenotype

    condition where aging cells release inflammatory molecules and enzymes

    Senescence-Associated Secretory Phenotype (SASP) refers to a condition where aging or damaged cells release a variety of inflammatory molecules, growth factors, and enzymes into their surroundings. This secretion can contribute to tissue dysfunction, chronic inflammation, and age-related diseases, including hair loss and alopecia, by affecting the local cellular environment and promoting further cellular damage.

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    1. 1430 Modeling the onset of senescence associated secretory phenotype predicts therapeutic targets Journal of Investigative Dermatology · 2018
    2. Cellular senescence in tissue repair: every cloud has a silver lining The International Journal of Developmental Biology · 2018 · 33 citations
    3. Oncogenic senescence: a multi-functional perspective Oncotarget · 2017 · 32 citations
    4. Imbalanced redox dynamics induce fibroblast senescence leading to impaired stem cell pools and skin aging Free Radical Biology and Medicine · 2025 · 7 citations
    5. Platelet Immune Interactions, Lifespan, and Senescence OBM Geriatrics · 2025 · 1 citations
    6. Senotherapeutic Potential of Araliadiol in Senescent Human Dermal Fibroblasts: An In Vitro Study Using Three Senescence Models Pharmaceutics · 2025
    7. The Yin–Yang of Stress and Senescence: Integrated Stress Response and SASP Crosstalk in Stem Cell Fate, Regeneration, and Disease Biocell · 2025
    8. 685 Modelling intrinsic and extrinsic cellular senescence in vitro with complex bioengineered human skin constructs Journal of Investigative Dermatology · 2024
    9. LB1672 Senescent melanocytes in nevus skin stimulate hair growth Journal of Investigative Dermatology · 2023
    10. Cellular Senescence: Ageing and Androgenetic Alopecia Dermatology · 2023
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