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    Did you mean Senescence-Associated Secretory Phenotype?
    Glossary Senescence-Associated Secretory Phenotype

    condition where aging cells release inflammatory molecules and enzymes

    Senescence-Associated Secretory Phenotype (SASP) refers to a condition where aging or damaged cells release a variety of inflammatory molecules, growth factors, and enzymes into their surroundings. This secretion can contribute to tissue dysfunction, chronic inflammation, and age-related diseases, including hair loss and alopecia, by affecting the local cellular environment and promoting further cellular damage.

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    Research 30 of 1000+

    1. 1430 Modeling the onset of senescence associated secretory phenotype predicts therapeutic targets Journal of Investigative Dermatology · 2018
    2. Cellular senescence in tissue repair: every cloud has a silver lining The International Journal of Developmental Biology · 2018 · 33 citations
    3. Oncogenic senescence: a multi-functional perspective Oncotarget · 2017 · 32 citations
    4. Imbalanced redox dynamics induce fibroblast senescence leading to impaired stem cell pools and skin aging Free Radical Biology and Medicine · 2025 · 7 citations
    5. Platelet Immune Interactions, Lifespan, and Senescence OBM Geriatrics · 2025 · 1 citations
    6. Senotherapeutic Potential of Araliadiol in Senescent Human Dermal Fibroblasts: An In Vitro Study Using Three Senescence Models Pharmaceutics · 2025
    7. The Yin–Yang of Stress and Senescence: Integrated Stress Response and SASP Crosstalk in Stem Cell Fate, Regeneration, and Disease Biocell · 2025
    8. 685 Modelling intrinsic and extrinsic cellular senescence in vitro with complex bioengineered human skin constructs Journal of Investigative Dermatology · 2024
    9. LB1672 Senescent melanocytes in nevus skin stimulate hair growth Journal of Investigative Dermatology · 2023
    10. Cellular Senescence: Ageing and Androgenetic Alopecia Dermatology · 2023
    11. 1349 Inducing fate changes at the hair follicle stem cell nice Journal of Investigative Dermatology · 2023
    12. 581 Spontaneous, Intrinsic Aging in Organ-Cultured Human Skin as Novel Ex Vivo Assay to Test Candidate Anti-Aging Actives Journal of Investigative Dermatology · 2022
    13. Il-10 family members as novel responders to genotoxic stress ScholarlyCommons (University of Pennsylvania) · 2015
    14. Cellular senescence and polycystic ovary syndrome: mechanisms and therapeutic strategies from a new perspective Annals of Medicine · 2025 · 2 citations
    15. Update on Melasma—Part I: Pathogenesis Dermatology and Therapy · 2022 · 10 citations
    16. Immunosenescence and inflammaging in Parkinson’s disease: mechanisms and therapeutic prospects Frontiers in Immunology · 2026
    17. Metformin and Malignant Tumors: Not Over the Hill Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · 2021 · 14 citations
    18. Dermal papilla cells and melanocytes response to physiological oxygen levels depends on their interactions Cell Proliferation · 2021 · 7 citations
    19. Aged Skin Cells Nurture Stem Cells toward Regeneration Journal of Investigative Dermatology · 2023 · 3 citations
    20. 090 Reactive lipids from the secretome of senescent fibroblasts modify the extracellular matrix with functional consequences for resident cells Journal of Investigative Dermatology · 2024
    21. OR2AT4, an Ectopic Olfactory Receptor, Suppresses Oxidative Stress-Induced Senescence in Human Keratinocytes Antioxidants · 2022 · 6 citations
    22. Keratinocyte Stem Cells: Role in Aging IntechOpen eBooks · 2022 · 1 citations
    23. Flavonoid 4,4′-dimethoxychalcone selectively eliminates senescent cells via activating ferritinophagy Redox biology · 2023
    24. The senescence-like activity of BMS-470539 is associated with anti-fibrotic actions in models of dermal fibrosis Arthritis Research & Therapy · 2025
    25. Evaluation of the phenotypic, proliferative and secretory profile of mesenchymal stem cells from adipose tissue captured by laser-assisted liposuction Digital Library of Theses and Dissertations (Universidade de São Paulo) · 2023
    26. Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1 Frontiers in Cell and Developmental Biology · 2020 · 3 citations
    27. Honokiol protects skin cells against inflammation, collagenolysis, apoptosis, and senescence caused by cigarette smoke damage International Journal of Dermatology · 2017 · 20 citations
    28. Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy Cell death and differentiation · 2015 · 56 citations
    29. Single‐cell transcriptomics reveals a senescence‐associated IL ‐6/ CCR6 axis driving radiodermatitis EMBO molecular medicine · 2022 · 9 citations
    30. Aging Skin: A Window to the Body CRC Press eBooks · 2016 · 1 citations