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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
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Research
5 / 1000+ results
research Non-Invasive Assessment of Hair Regeneration in Androgenetic Alopecia Mice In Vivo Using Two-Photon and Second Harmonic Generation Imaging
New imaging techniques show testosterone delays hair growth and shrinks follicles in mice, but have limited depth for viewing.
research Pan-Tissue Scaling of Stiffness Versus Fibrillar Collagen Reflects Contractility-Driven Strain That Inhibits Fibril Degradation
The study investigates the relationship between tissue stiffness and Collagen-I levels across various animal tissues, revealing a sub-linear scaling pattern. Using second harmonic generation imaging and mass spectrometry, the research shows that tissue stiffness correlates with Collagen-I levels, similar to cellularized Collagen-I gels but not acellular ones. The study highlights that cellular myosin-II contraction and matrix metalloproteinase inhibitors indicate collagenase activity is suppressed by strain rather than stress. This suppression is observed in tissues like embryonic hearts and tendons, which differ significantly in collagen levels and stiffness. The findings suggest that tissue stiffness scaling is influenced by contractility, providing insights into organ size scaling, microgravity effects, and potential therapeutic approaches.
research Multiphoton Microscopic Imaging of Rabbit Dorsal Skin
Multiphoton microscopy effectively images rabbit skin structures in detail without staining and shows differences from human skin.
research Application of Multiphoton Microscopy in Dermatological Studies: A Mini-Review
Multiphoton microscopy is a promising tool for detailed skin imaging and could improve patient care if its challenges are addressed.
research Long-Term Intravital Imaging of the Cornea, Skin, and Hair Follicle by Multiphoton Microscope
Multiphoton microscopy can effectively image live cells in cornea, skin, and hair follicles over time.
Community Join
5 / 1000+ resultscommunity Second opinion on my dermatologist’s advice?
The user is considering switching from finasteride and oral minoxidil to dutasteride and a higher dose of oral minoxidil, taken intermittently, based on their dermatologist's advice. They are unsure about claims that finasteride loses effectiveness after a year and that minoxidil doesn't need daily dosing, and they are seeking community input on these points.
community second shed on dutasteride, but a woman
A woman experiencing hormonal hair loss is on dutasteride and bicalutamide, which initially improved her hair, but she is now experiencing a second shedding phase with significant short hair loss. Despite normal hormone levels and no deficiencies, she is unsure if this shedding is normal and seeks advice.
community Second shed or just not working?
A 24-year-old started losing hair at 17 and began treatment with Dutasteride, Minoxidil, Biotin, and Saw Palmetto shampoo in November 2023. After initial success, hair shedding resumed, leading to concerns about treatment quality and effectiveness; the user plans to consult a dermatologist and consider buying medications directly from a pharmacy.
community Second shed and more abnormalities
The user has been using oral finasteride for 15 months and oral minoxidil for 6 months, and developed alopecia areata, for which a dermatologist prescribed calcipotriol/betamethasone. The treatment is helping, but the user is experiencing another shedding phase and is concerned about the effects of the steroid cream and the cause of hair loss.
community Second shed, non-stop flaking, itching
The user is experiencing a second hair shedding phase and increased flaking and itching while using minoxidil 5% nightly and microneedling every two weeks, with needle length increasing over time. Other users suggest the hair loss may continue without the use of finasteride.