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research Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp

227 citations , January 1998 in “Journal of Endocrinology”

This study found that dermal papilla cells from balding scalp hair follicles have significantly higher levels of androgen receptors than those from non-balding follicles, supporting their in vivo androgen response.

research 496 Evaluation of extracts containing red clover using dermal papilla cells in the development of a scalp treatment system targeting hair loss and hair damage

June 2020 in “Journal of Investigative Dermatology”

This study reported that a treatment serum containing ingredient blends with panthenol, licorice extract, and red clover extract significantly improved hair volume, scalp coverage, and reduced hair breakage over 6 months in individuals with thinning or damaged hair.

research Anti-Hair Loss Activity of Healthy Human Scalp-Derived Staphylococcus capitis KMH304 Ferment Filtrate in Human Hair-Follicle Dermal Papilla and Keratinocyte Cells

April 2026 in “Microorganisms”

This study suggests that Staphylococcus capitis ferment filtrate (SCFF) may promote hair growth and scalp health by modulating pathways related to hair loss, aging, and oxidative stress in vitro.

research Pre-aggregation of scalp progenitor dermal and epidermal stem cells activates the WNT pathway and promotes hair follicle formation in in vitro and in vivo systems

17 citations , December 2019 in “Stem Cell Research & Therapy”

This study found that their system effectively supports the rapid formation of human hair follicle organoids, providing a platform for studying hair regeneration and drug screening.

research Scalp microbiome in male androgenetic alopecia: 16S rRNA sequencing-based clinical characterization, mouse model validation, and effects on hair follicle cells

July 2026 in “Frontiers in Cellular and Infection Microbiology”

This study found that patients with androgenetic alopecia had increased scalp microbial diversity and reduced Staphylococcus abundance, particularly in the frontal and vertex regions, suggesting this dysbiosis as a sensitive indicator of AGA.

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Community Join

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community Hair Transplant + Scalp Treatments

92 upvotes 5 months ago

The conversation discusses the benefits of combining scalp stem cell treatments and exohealer with RF microneedling before a hair transplant. The original poster recommends these treatments for better results.

community How Does Exosome Therapy Work for Hair Loss?

in Research/Science 5 upvotes 2 years ago

Exosome hair therapy involves injecting stem cell-derived exosomes into the scalp to boost hair follicle regeneration and repair. Exosomes, which are not stem cells but products of them, contain bioactive chemicals and specific growth factors that promote new blood vessel formation, increase cell proliferation, reduce inflammation, and improve tissue repair, all crucial for hair health.

community Fun thought experiment about halting hair loss permamently

59 upvotes 2 years ago

A user proposed genetically engineering scalp stem cells to stop androgen receptors from causing hair loss. Others discussed the feasibility, existing research, and potential issues with this approach, including targeting the correct cells and unintended effects.

community Scalp Microneedling with Stemcell and Exohealer

149 upvotes 3 months ago

A user tried scalp microneedling with stem cells and exohealer in Korea for hair loss, costing $2.5k, and is awaiting results. Another user shared their experience using various growth factors and supplements, noting it improves existing hair but doesn't grow new hair, requiring monthly maintenance.

community Adipose tissue layer and stem cells.

4 upvotes 11 months ago

Adipose fat cells and stem cells may help treat hair loss by restoring the scalp's thickness. Treatments like NanoFat injections and Botox are discussed for their potential to promote hair growth.

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Learn

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learn Centella

Can centella improve scalp blood flow and thicken hair? What the evidence says There is no clinical trial of centella asiatica for hair loss and no study measuring scalp blood flow in people using it; the only hair-related evidence is a 2017 cell-culture study. Centella products are cosmetics that may soothe an irritated scalp, and the link between scalp circulation and pattern hair loss is itself unproven.

learn vitamin b2

What does vitamin B2 do for cellular energy, and does it affect scalp circulation? Riboflavin (vitamin B2) is needed for cell energy metabolism, according to the NIH. No study has shown that it improves scalp circulation or hair growth in people who are not deficient.

learn Sulforaphane

What is sulforaphane, and what does research say about scalp and hair follicles? Sulforaphane is a compound from broccoli and related vegetables. Lab and mouse studies suggest effects on follicle cells and on DHT breakdown, but it has not been tested for hair in people.

learn Osteopontin

What role does Osteopontin play in protecting and repairing hair follicles? In mouse studies osteopontin switched on hair stem cells, but an osteopontin-derived peptide suppressed growth in human scalp tissue. Whether it protects human follicles is unknown.

learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn retinol

What’s the difference between retinol and salicylic acid in scalp care and follicle renewal? Salicylic acid loosens surface scale and is an approved over-the-counter dandruff ingredient; retinoids change how skin cells grow and have only lab evidence for hair. Neither is shown to regrow hair, and each has its own cautions.

learn Stem Cell Factor

learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn SCUBE3

Signalling protein made in the hair follicle

learn Exosomes

Tiny cell-derived particles offered by clinics as an injectable treatment

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Clinics

6 / 73 results

All 73 clinic results →

Experts

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Trichologist
Kirsten J. Scalp
Greenville, SC, United States

Kirsten J. Scalp