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    Did you mean Retinoic Acid Receptor-Related Orphan Receptor Alpha?
    Glossary Retinoic Acid Receptor-Related Orphan Receptor Alpha

    regulates gene expression related to circadian rhythm and metabolism

    Retinoic Acid Receptor-Related Orphan Receptor Alpha (RORα) is a type of nuclear receptor that plays a crucial role in regulating various biological processes, including circadian rhythm, immune function, and metabolism. It acts by binding to specific DNA sequences and influencing the expression of certain genes, making it important for maintaining physiological balance and responding to environmental changes.

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      community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

       63 upvotes 2 years ago
      Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

      community Why everyone should be using topical Dutasteride

       45 upvotes 3 months ago
      Topical Dutasteride, especially in a liposomal base, is recommended for enhanced scalp DHT suppression when used with oral Dutasteride. It is suggested to apply it twice a week for effective results without significant systemic impact.

      community Any treatment not nuking systemic DHT levels?

       16 upvotes 7 months ago
      Hair loss treatments that avoid significantly lowering systemic DHT levels, focusing on topical options like dutasteride mesotherapy, minoxidil, and ketoconazole. The user is exploring alternatives like KX-826 and RU58841 due to concerns about hormone levels.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 2 years ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Minoxidil works only with Retinoic acid

       314 upvotes 1 year ago
      Minoxidil is more effective when combined with retinoic acid, such as tretinoin or tazarotene, enhancing hair growth. Some users experience significant regrowth, while others see minimal effects or side effects.
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