September 2022 in “Zenodo (CERN European Organization for Nuclear Research)” This article discusses Fluxactive Complete, a natural supplement for prostate health, and reports no new clinical results.
9 citations
,
October 2019 in “Dermatologic Therapy” This study observed that oral tofacitinib was reasonably well-tolerated but had limited efficacy in treating alopecia areata, with a clinical response seen in 41.4% of patients over six months.
In this study, introducing the rat OTC gene into spf-ash mice led to increased OTC activity and normalized hair growth and biochemical markers like urinary orotic acid and serum citrulline, partially correcting the symptoms of OTC deficiency.
This study found that a short-term treatment with all-trans retinoic acid may effectively stabilize platelet counts in idiopathic thrombocytopenic purpura patients experiencing fluctuations during thrombopoietin receptor agonist therapy.
2 citations
,
April 2023 in “Pharmaceuticals” This review discusses the controversial cardiovascular safety and efficacy of subcutaneous testosterone therapy in postmenopausal women, noting that its long-term use appears safe, but CV risk assessments remain disputed.
April 2018 in “The Journal of urology/The journal of urology” This study identified several patient-specific factors that can predict both the likelihood of undergoing and failing a post-TURP void trial, aiding in the selection of candidates for immediate assessment.
January 2026 in “American Journal of Medical Genetics Part A” The researchers reported two brothers with a new variant of X-linked trichothiodystrophy associated with an RNF113A gene mutation, highlighting features such as intellectual disability and growth failure, but without previously reported endocrinological or genital abnormalities, underlining the importance of genetic counseling for such variants.
October 2020 in “Der Hautarzt” This case study demonstrated that off-label tofacitinib treatment led to full regrowth of scalp hair after 18 months in a patient with alopecia areata universalis, following unsuccessful therapies.
10 citations
,
December 2019 in “in Vivo” This study found that administering testosterone to ovariectomized female rats decreased endometrial tight junction complexity and expression of specific proteins, potentially affecting embryo implantation.
July 2025 in “Journal of Investigative Dermatology” 4 citations
,
January 2014 in “The Journal of urology/The journal of urology” This study found that folliculin deficient renal cancer cells were more sensitive to irradiation due to increased autophagic cell death, suggesting a potentially enhanced therapeutic approach when combined with autophagy inducers like rapamycin.
39 citations
,
May 2014 in “Frontiers in Pharmacology” In this study, CD4+CD25+FoxP3+ Regulatory T cells were found to reduce TGF-b1 induced lung fibrosis and fibrocyte accumulation in mice, partly by suppressing fibroblast growth factor 9.
June 2022 in “Frontiers in Immunology” This report describes a case of alopecia universalis successfully treated with tofacitinib, though it was associated with increased peripheral blood cytokine levels.
April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study demonstrates that extracellular ATP induced by UV radiation promotes melanin production in human melanocytes, suggesting ATP-induced purinergic signaling may influence skin pigmentation.
December 2023 in “The journal of cell biology/The Journal of cell biology” This study developed the mTurquoise2-Col4a1 mouse model and used fluorescent tagging of collagen IV to offer new insights into basement membrane dynamics during hair follicle budding, revealing that basement membranes are flexible and stable structures in developing skin tissue.
1 citations
,
October 2023 in “Journal of the Endocrine Society” In this study, researchers found that transgender men exhibited impaired autonomic modulation during sympathetic stimulation compared to cisgender women, potentially due to testosterone treatment affecting cardiac autonomic modulation.
January 2023 in “Skin appendage disorders” The case study reports a patient with acute telogen effluvium in the donor region post-hair transplant, highlighting trichoscopic findings that aid in diagnosis and reassuring the self-resolutive nature of this condition.
6 citations
,
January 2013 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin” In this study, TASP0382088 showed potent selective inhibition of the ALK5 receptor, significantly reducing Smad2 phosphorylation in mouse skin following topical application.
2 citations
,
September 1971 in “Metabolism, clinical and experimental” In this study, patients with testicular feminization syndrome showed limited anabolic responsiveness to dihydrotestosterone, potentially due to reduced affinity of nuclear receptor sites for androgenic steroids rather than defective testosterone conversion.
3 citations
,
November 2005 in “British Journal of Dermatology” In this case study, a 21-year-old man with alopecia universalis experienced temporary hair regrowth after treatment with recombinant human bone morphogenetic protein-2 following a tibial fracture.
4 citations
,
February 2020 in “Cell & tissue research/Cell and tissue research” This study suggests that adult hair follicle stem cells can survive and potentially differentiate into neuronal cells after being transplanted in a mouse model of traumatic brain injury, indicating promise for TBI therapy.
July 2025 in “Journal of Investigative Dermatology”
This study suggests that skin tumor cells in tuberous sclerosis complex may promote hamartoma morphogenesis by expressing and releasing higher levels of cathepsin B.
December 2025 in “Mycoses” In this study involving a murine skin infection model, researchers found that the Trichophyton mentagrophytes strain TIMM 2789, specific to rodents, induced typical symptoms of superficial dermatophytosis, while revealing that the fungal gene SUB6 is not essential for virulence.
March 2023 in “Scientific Reports” In this rodent model study, the researchers reported that using low-intensity focused ultrasound with phenytoin enhanced its anti-epileptic efficacy by disrupting plasma protein binding in a region-specific manner, reducing seizure frequency and duration.
February 2011 in “Annales de dermatologie et de vénéréologie” This study found that tofacitinib was well tolerated and led to clinical improvement in 77% of potential responders with severe alopecia areata, alopecia totalis, or alopecia universalis.
10 citations
,
August 2022 in “Bulletin of Mathematical Biology” This study demonstrated that the Turing bifurcation, typically a pitchfork bifurcation under zero-flux conditions, becomes transcritical under fixed boundary conditions, highlighting the importance of considering boundary condition variations in morphogenetic analyses.
8 citations
,
February 2016 in “The American Journal of Dermatopathology” In this study, the researchers found that transplanted hair follicles undergo significant morphological changes, including a thickened dermal sheath and increased hair shaft diameter, which are associated with altered follicular vascularization.
8 citations
,
July 2016 in “Hair transplant forum international” This article discusses the increasing use of follicular unit extraction in hair transplant surgery and presents no new research findings.
5 citations
,
August 2018 in “PubMed” This case report documented successful full hair regrowth in an 8-year-old with alopecia universalis after oral tofacitinib treatment, but mild headaches led to discontinuation.