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    Glossary U2HR protein

    truncated protein inhibiting hair growth gene, affecting follicles

    The U2HR protein is a truncated form of the U2HR (U2 Hairless Repressor) gene product, which plays a role in hair growth regulation. It acts as an inhibitor of the hairless (HR) gene, which is crucial for hair follicle cycling and maintenance. By interfering with the HR gene's function, the U2HR protein can potentially lead to conditions like alopecia, where hair growth is disrupted.

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    Research 21

    1. Marie Unna hereditary hypotrichosis: A Turkish family with loss of eyebrows and a <i>U2HR</i> mutation American Journal of Medical Genetics - Part A · 2010 · 11 citations
    2. Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis Nature Genetics · 2009 · 181 citations
    3. Two females with hair loss Journal der Deutschen Dermatologischen Gesellschaft · 2019
    4. A TP63 Mutation Causes Prominent Alopecia with Mild Ectodermal Dysplasia 2020 · 2 citations
    5. Biology and Genetics of Hair Annual Review of Genomics and Human Genetics · 2010 · 89 citations
    6. Molecular Genetics of Alopecias Current problems in dermatology · 2015 · 9 citations
    7. Disease causing homozygous variants in the human hairless gene International Journal of Dermatology · 2015 · 7 citations
    8. Hair loss and its management in children Expert Review of Dermatology · 2011 · 5 citations
    9. A Missense Mutation within the Helix Initiation Motif of the Keratin K71 Gene Underlies Autosomal Dominant Woolly Hair/Hypotrichosis Journal of Investigative Dermatology · 2012 · 78 citations
    10. Alopezien und Hypotrichosen im Kindesalter Der Hautarzt · 2014 · 5 citations
    11. Novel mutations in the keratin-74 (KRT74) gene underlie autosomal dominant woolly hair/hypotrichosis in Pakistani families Human Genetics · 2010 · 40 citations
    12. Genetic Hair Disorders: A Review Dermatology and Therapy · 2019 · 26 citations
    13. Current Genetics in Hair Diseases InTech eBooks · 2013 · 1 citations
    14. Pili Torti: A Feature of Numerous Congenital and Acquired Conditions Journal of clinical medicine · 2021 · 9 citations
    15. Marie Unna hereditary hypotrichosis: Identification of a U2HR mutation in the family from the original 1925 report Journal of the American Academy of Dermatology · 2011 · 14 citations
    16. Identification of a novel heterozygous mutation in the first Japanese case of Marie Unna hereditary hypotrichosis The Journal of Dermatology · 2013 · 6 citations
    17. Marie-unna hereditary hypotrichosis International Journal of Trichology · 2014 · 4 citations
    18. Clinical course of the first Japanese family with Marie Unna hereditary hypotrichosis: a follow-up report European Journal of Dermatology · 2018
    19. Odd-Looking Hair and Progressive Alopecia in Mother and Son JAMA Dermatology · 2014
    20. Development of squamous cell carcinoma from erythroplasia of Queyrat following photodynamic therapy European Journal of Dermatology · 2018 · 3 citations
    21. Recalcitrant Female Pattern Hair Loss Like Alopecia Unveils Unexpected Rare Entity Clinical Cosmetic and Investigational Dermatology · 2025