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This study suggests that metformin might serve as a diagnostic and therapeutic option to distinguish insulin resistance-related ovarian testosterone excess from a testosterone-secreting tumor in women with virilization.

This study reported that overexpressing ornithine decarboxylase in C57Bl/6 mice increased their sensitivity to tumor promotion by TPA, a change reversible by doxycycline treatment.

This study identified a radio-resistant population of Krt15+ stem cells in the mouse small intestine that can initiate tumors, suggesting potential targets for colon cancer therapy.

This study demonstrates that Krt15 marks long-lived, multipotent, and injury-resistant crypt cells in the small intestine, which may serve as the cell of origin in intestinal cancer.

This study in a transgenic mouse model found that repressing overexpression of ornithine decarboxylase reduced papilloma development, indicating its role in tumor promotion sensitivity.

In this study, researchers demonstrated that the expression of the oncogene SmoM2 leads to basal cell carcinoma in the ear epidermis of mice but not in the back skin, with differences in susceptibility linked to the composition of the extracellular matrix.

This study suggests that the TNF-α system may contribute to hyperandrogenism, obesity, and insulin resistance in polycystic ovarian syndrome, independent of the C850T polymorphism.

This case report suggests that PCOS can present with virilization and rapidly increasing testosterone levels, and highlights oral contraceptives' effectiveness in managing hyperandrogenism in such cases.

In this case report, a 71-year-old woman with severe hyperandrogenism and virilization revealed a bilateral ovarian steroid cell tumor, confirmed after adnexectomy, resulting in normalized testosterone levels and improved hirsutism post-surgery.

This article reviews the characteristics, diagnosis, and management of premature adrenarche and suggests it may predict future ovarian hyperandrogenism in some adolescents; no new clinical results are reported.

This systematic review identified several factors contributing to increased cardiovascular risk in women with polycystic ovary syndrome, including insulin resistance, obesity, inflammation markers, and microbiota alterations linked to elevated trimethylamine-N-oxide levels.

This study found that the Nap-F3K-CA hydrogel, when used on burn wounds, demonstrated effective antibacterial and anti-inflammatory properties, promoting accelerated skin repair, decreased wound infections, and improved healing processes, highlighting its potential as a clinical burn wound dressing.

This review highlights that pediatric hirsutism, often linked to endocrine, metabolic, genetic, or neoplastic disorders, requires comprehensive evaluation to prevent long-term health issues, integrating advancements in androgen biosynthesis understanding and diagnostic and management strategies.

This article reviews existing knowledge on postmenopausal hyperandrogenism and highlights diagnostic challenges, reporting no new clinical results.

This review discusses the similarities in clinical, endocrine, and ultrasonographic features between PCOS and other disorders with excessive androgen secretion, emphasizing the importance of accurate diagnosis but reports no new clinical results.

This case report describes a woman with severe hyperandrogenism due to ovarian tumors, where surgical removal led to dramatic improvement in her diabetes control and reduced insulin requirements.

This article reviews the causes and treatments of hypertrichosis and hirsutism and reports no new clinical findings; the authors compare diagnostic strategies and discuss available treatment options.

This case report describes a 15-year-old girl with severe hyperandrogenaemia linked to both an ovarian androgen-secreting tumor and HAIR-AN syndrome, highlighting the complexity of diagnosing polycystic ovarian syndrome.

This case series detailed three postmenopausal women with ovarian steroid cell tumors, highlighting that such tumors may present asymptomatically or with virilization, and found surgery effectively normalized androgen levels, with distinctive imaging features aiding diagnosis.

This review discusses the definition of polycystic ovary syndrome proposed by the AE-PCOS Society Task Force, emphasizing hyperandrogenism, ovarian dysfunction, and excluding related disorders, while noting potential variations needing more research.

This review provides a comprehensive examination of the causes and treatments for hirsutism in women, highlighting the role of pharmacological therapies and novel nanotechnology-based methods in improving patient quality of life.

This review discusses the diagnosis and treatment of hirsutism, emphasizing that a systematic evaluation can determine its cause, while combination therapy effectively manages the condition for most patients.

This article discusses the importance of recognizing and distinguishing polycystic ovary syndrome from similar endocrine disorders, and reports no new clinical results.

The painting of an 18th-century Sicilian baroness shows she had hair loss, possibly due to ovarian issues, insulin resistance, or a specific type of tumor.

This case series observed the efficacy of GnRH analogues in diagnosing and treating various forms of ovarian hyperandrogenism, illustrating their role in symptom management without surgery, particularly for benign conditions and refractory androgen excess.

This article reviews the pathophysiology and causes of androgen-mediated hair growth in hirsutism but does not report any clinical outcomes; treatment aspects are discussed separately.

This article discusses polycystic ovary syndrome, describing its diagnostic criteria and noting that it is a common cause of anovulatory infertility and hirsutism, without reporting new research findings.

In this study, a 37-year-old female with resistant hypertension and signs of Cushing's syndrome and primary aldosteronism was found to have normal cortisol levels but high levels of cortisol and aldosterone via adrenal venous sampling, leading to a diagnosis confirmed by right adrenalectomy.

This review explores the evaluation and treatment of hirsutism, emphasizing a systematic approach to uncovering its causes and recommending combination therapies for effective management, but presents no new results.