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      Theoretical Considerations in Laser Hair Removal

      research Theoretical considerations in laser hair removal

      150 citations , April 1999 in “Dermatologic Clinics”
      This article reviews the biological and physical principles of laser hair removal and reports that current laser systems do not consistently achieve permanent hair follicle destruction across treated areas.
      Tactile Innervation Densities Across the Whole Body

      research Tactile innervation densities across the whole body

      142 citations , September 2020 in “Journal of neurophysiology”
      This study estimates that young adults have about 230,000 tactile afferent fibers innervating their skin, with density varying by region and decreasing with age.
      Microneedles as the Technique of Drug Delivery Enhancement in Diverse Organs and Tissues

      research Microneedles as the technique of drug delivery enhancement in diverse organs and tissues

      140 citations , December 2017 in “Journal of Controlled Release”
      This study reviews the evolution and modifications of microneedle drug delivery systems, initially designed for percutaneous use, now expanded for targeting a variety of tissues and organs such as ocular, oral mucosal, and gastrointestinal, suggesting widespread future applicability.
      Protoporphyrin IX: The Good, the Bad, and the Ugly

      research Protoporphyrin IX: the Good, the Bad, and the Ugly

      138 citations , November 2015 in “Journal of Pharmacology and Experimental Therapeutics”
      This review discusses the mechanisms associated with protoporphyrin IX in living cells and reports no clinical results; the authors emphasize its potential in cancer diagnosis and the risks of toxicity.
      TGF-β Family Signaling in Stem Cells

      research TGF-β family signaling in stem cells

      132 citations , August 2012 in “Biochimica et Biophysica Acta (BBA) - General Subjects”
      This review discusses the roles of TGF-β family signaling in regulating normal and cancer stem cells and highlights the need for further research to develop potential cancer treatments; it reports no new results.
      Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

      research Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles

      130 citations , January 1994 in “Differentiation”
      In this study, researchers found that bulge cells in mouse hair follicles undergo transient proliferation during early anagen, indicating their role as follicular stem cells. However, another factor beyond dermal papilla proximity may be required to initiate a new anagen phase.
      Structural Abnormalities of the Hair Shaft

      research Structural abnormalities of the hair shaft

      126 citations , January 1987 in “Journal of The American Academy of Dermatology”
      This article reviews the classification of hair shaft abnormalities, outlining their diagnostic features, but does not present new research findings.
      TRP Channels in Skin Biology and Pathophysiology

      research TRP Channels in Skin Biology and Pathophysiology

      124 citations , December 2016 in “Pharmaceuticals”
      This review discusses the functions and potential therapeutic targeting of TRP ion channels in the skin, noting their involvement in both physiological processes and various pathological conditions, but reports no new experimental results.
      Dermatologic Changes Associated With Interleukin 2 Administration

      research Dermatologic Changes Associated With Interleukin 2 Administration

      123 citations , September 1987 in “JAMA”
      This study observed that patients receiving IL-2 immunotherapy developed a skin eruption characterized by burning and pruritus, which resolved shortly after stopping the infusion, suggesting that IL-2 mediated these effects.
      Permanent Alopecia After Cranial Irradiation: Dose–Response Relationship

      research Permanent alopecia after cranial irradiation: Dose–response relationship

      120 citations , October 2004 in “International journal of radiation oncology, biology, physics”
      In this study, the researchers established a dose–response relationship between the hair follicle dose during cranial irradiation and the development of permanent alopecia, with other factors showing limited correlation.
      Potassium Channel Openers: Pharmacological and Clinical Aspects

      research Potassium channel openers: pharmacological and clinical aspects

      119 citations , October 1992 in “Fundamental & Clinical Pharmacology”
      This review discusses the pharmacological properties and therapeutic potential of K+ channel opening compounds, noting their prospective use in treating cardiovascular and respiratory conditions, but reports no new results.
      Epithelial Skin Biology: Stem Cells and Epidermal Homeostasis

      research Epithelial Skin Biology

      118 citations , January 2016 in “Current Topics in Developmental Biology”
      This essay discusses the establishment, maintenance, and role of skin stem cells in tissue homeostasis, wound repair, and their relation to skin cancer, without reporting new experimental findings.
      Deep Insight of Design, Mechanism, and Cancer Theranostic Strategy of Nanozymes

      research Deep Insight of Design, Mechanism, and Cancer Theranostic Strategy of Nanozymes

      112 citations , November 2023 in “Nano-Micro Letters”
      This review discusses the developments over the past five years in nanozyme-based theranostics for tumor therapy, including their classification, design, and synergistic strategies. It also outlines the challenges and prospects of using nanozymes to enhance selectivity, biosafety, repeatability, and stability in therapeutic applications.
      Quantitative Single-Cell Approaches to Stem Cell Research

      research Quantitative Single-Cell Approaches to Stem Cell Research

      106 citations , November 2014 in “Cell Stem Cell”
      This review discusses advanced techniques for investigating stem cell fate at the single-cell level, including lineage tracing, time-lapse imaging, and molecular profiling, but reports no new research results.
      FGF Family: From Drug Development to Clinical Application

      research FGF Family: From Drug Development to Clinical Application

      103 citations , June 2018 in “International Journal of Molecular Sciences”
      This review discusses the applications and research on fibroblast growth factors, including their use in wound healing, diabetes, and cancer, but it reports no new clinical results.
      Neural Mechanisms of Hair Growth Control

      research Neural Mechanisms of Hair Growth Control

      101 citations , January 1997 in “Journal of Investigative Dermatology Symposium Proceedings”
      This review discusses neural mechanisms involved in hair growth control, focusing on piloneural interactions, but reports no clinical findings; the authors suggest further exploration for managing hair growth disorders.
      Diagnosis of Polycystic Ovary Syndrome

      research Diagnosis of Polycystic Ovary Syndrome

      97 citations , February 2007 in “Clinical Obstetrics and Gynecology”
      This article reviews the diagnostic criteria and prevalence of PCOS, emphasizing its status as the most common endocrine disorder among women of reproductive age, with no new clinical results reported.
      S1 Guideline Long/Post-COVID

      research S1-Leitlinie Long-/Post-COVID

      96 citations , December 2022 in “Pneumologie”
      This guideline review discusses current symptoms, diagnostic approaches, and treatments for Long- and Post-COVID, based on today's knowledge, and emphasizes its practical application with ongoing updates as new insights emerge.