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    Glossary TGF-beta signaling

    cellular communication process regulating growth, differentiation, and immune responses

    TGF-beta signaling, or Transforming Growth Factor-beta signaling, is a cellular communication process that regulates various biological functions, including cell growth, differentiation, and immune responses. This pathway involves the binding of TGF-beta proteins to specific receptors on the cell surface, which then activate intracellular molecules called SMADs to transmit signals to the nucleus, influencing gene expression. This pathway is crucial in maintaining tissue homeostasis and has implications in conditions like cancer, fibrosis, and alopecia.

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    1. 376 Tsc2 disruption in mesenchymal progenitors regulates hair follicles and TGF beta signaling 2019
    2. Exploring the Complexities of TGF-beta Signaling in Keloids: Beyond the Classical Smad Pathway International Journal of Molecular Sciences · 2026
    3. Faculty Opinions recommendation of Expression of truncated latent TGF-beta-binding protein modulates TGF-beta signaling. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2005
    4. TGFβ signaling regulates lipogenesis in human sebaceous glands cells BMC Dermatology · 2013 · 44 citations
    5. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012 · 321 citations
    6. TGF-β Family Signaling in Epithelial Differentiation and Epithelial–Mesenchymal Transition Cold Spring Harbor Perspectives in Biology · 2017 · 82 citations
    7. TGF-β family signaling in stem cells Biochimica et Biophysica Acta (BBA) - General Subjects · 2012 · 132 citations
    8. CXXC5: A novel regulator and coordinator of TGF-β, BMP and Wnt signaling Journal of Cellular and Molecular Medicine · 2018 · 28 citations
    9. Injectable platelet-rich fibrin promotes proliferation and trichogenic inductivityof dermal papilla cells through activating TGF-β/Smad signaling pathway Cellular and Molecular Biology · 2024 · 4 citations
    10. From hair to liver: emerging application of hair follicle mesenchymal stem cell transplantation reverses liver cirrhosis by blocking the TGF-β/Smad signaling pathway to inhibit pathological HSC activation PeerJ · 2022 · 4 citations
    11. 1407 Mechanical force activation of TGF-β signaling controls hair follicle regression Journal of Investigative Dermatology · 2023
    12. Langerin+ Dendritic Cells in Cutaneous Fibrosis: The TGF-β1 Signaling Axis Clinical Cosmetic and Investigational Dermatology · 2025
    13. Cooperation of TGF‐β and FGF signalling pathways in skin development Cell Proliferation · 2023 · 23 citations
    14. Hair Follicle Development of Rex Rabbits Is Regulated Seasonally by Wnt10b/β-Catenin, TGFβ-BMP, IGF1, and EGF Signaling Pathways Animals · 2023 · 1 citations
    15. Network pharmacology and in vivo experimental analysis for validating the antifibrotic potential of Punica granatum leaves against skin scleroderma: the role of oxidative stress, inflammation and TGF-β1/Snail 1/p-Smad 3 signaling pathway Inflammopharmacology · 2026
    16. Edar Signaling in the Control of Hair Follicle Development 2005 · 71 citations
    17. Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state Developmental cell · 2022 · 25 citations
    18. Live imaging of Smad2/3 signaling in mouse skin wound healing Wound repair and regeneration · 2007 · 12 citations
    19. MiR-23b and miR-133 cotarget TGFβ2/NOTCH1 in dermal fibroblasts and affect hair follicle development in sheep Research Square (Research Square) · 2023
    20. Dermal niche signaling and epidermal stem cells Advances in stem cells and their niches · 2019
    21. 484 Transforming growth factor-β signaling-mediated wound healing is required hair follicle neogenesis Journal of Investigative Dermatology · 2024
    22. Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages Nature Communications · 2016 · 115 citations
    23. Co-opting Developmental Signaling Pathways to Promote Wound Healing Recent clinical techniques, results, and research in wounds · 2018 · 1 citations
    24. TGFβ family mimetic peptide promotes proliferation of human hair follicle dermal papilla cells and hair growth in C57BL/6 mice Biomedical dermatology · 2018 · 9 citations
    25. A role for the Tgf-β/Bmp co-receptor Endoglin in the molecular oscillator that regulates the hair follicle cycle Journal of Molecular Cell Biology · 2018 · 26 citations
    26. Let-7b promotes alpaca hair growth via transcriptional repression of TGFβR I Gene · 2015 · 13 citations
    27. Hair Follicle Stem Cells: the Signaling Hub of the Skin Journal of cellular immunology · 2024
    28. A role for the Tgf-β/Bmp co-receptor Endoglin in the molecular oscillator that regulates the hair follicle cycle bioRxiv (Cold Spring Harbor Laboratory) · 2017
    29. Identification of key genes and signaling pathways related to Hetian sheep wool density by RNA-seq technology PLOS ONE · 2022 · 7 citations
    30. Hair-Growth-Promoting Effects of the Fish Collagen Peptide in Human Dermal Papilla Cells and C57BL/6 Mice Modulating Wnt/β-Catenin and BMP Signaling Pathways International Journal of Molecular Sciences · 2022