December 2016 in “Journal of evolution of medical and dental sciences” This study reported common skin changes and symptoms associated with thyroid disorders, such as dry skin in hypothyroidism and warm, soft skin in hyperthyroidism, and noted urticaria as a frequent autoimmune association in hypothyroid patients.
141 citations
,
January 1984 in “Journal of The American Academy of Dermatology” This review discusses skin changes during pregnancy, highlighting both pregnancy-specific and common physiologic changes, but reports no new clinical findings.
3 citations
,
December 2021 in “Proteins” This study found that straight crimp mutant wool differs from crimpy wool in the layout of cortical cells and the relative proportions of keratin and keratin-associated proteins.
31 citations
,
September 2016 in “PLoS ONE” The researchers reported that in hairless mice, epidermal cell division orientations and epidermal thickness varied by body site, with dorsal and ear epidermis primarily dividing parallel to the basement membrane, unlike hind paw and tail epidermis.
9 citations
,
March 2005 in “International Journal of Cosmetic Science” This study found that torsional measurements can effectively distinguish the effects of hair care products on the cuticle versus the cortex of hair fibers, unlike tensile measurements.
This review re-examines hair blowouts as a material science process, where water acts as a plasticizer altering keratin's glass-transition temperature, allowing for temporary hair shaping through a moisture-induced matrix state change under heat and tension.
1 citations
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May 2006 in “Thyroid Research and Practice” In this study, 56% of patients with hypothyroidism had dry, coarse skin, while weight gain and lethargy were also common complaints.
7 citations
,
December 2010 in “대한의생명과학회지” In this study using C57BL/6N mice, the researchers found that skin thickness, mast cell counts, and immunoreactive density of certain cytokines increased at various stages of hair follicle growth following depilation.
4 citations
,
January 2006 in “International Journal of Cosmetic Science” This study found that scanning electron microscopy with argon sputter etching visualizes hair lipids at the cell membrane complex as distinctive convex structures, shedding light on their role and localization in human hair.
June 2026 in “British Journal of Dermatology” In this study, 84% of menopausal participants in England reported hair symptoms like shedding, thinning, and texture changes, with many seeking advice online and from nonmedical sources, highlighting the need for better information and support pathways.
January 2005 in “Chinese Journal of Veterinary” This study observed that hairless mice of different strains initially grow hair but soon develop alopecia and other skin and pigmentation changes with age.
79 citations
,
November 2010 in “Journal of Neuroscience” In this study, researchers found that simple hair clipping in mice induced dynamic plasticity and axogenesis in skin sensory axons, linked to follicular activation and HGF signaling.
7 citations
,
January 2009 in “Indian Journal of Dermatology Venereology and Leprology” Hair changes may indicate disease activity in pemphigus patients.
September 1998 in “Journal of The European Academy of Dermatology and Venereology” Old people's nails often have problems due to body changes, more diseases, and self-care difficulties, affecting their movement and hand use.
46 citations
,
July 2015 in “Wound repair and regeneration” This study found that keloid tissues exhibit epithelial-mesenchymal transition-related changes and alterations in gene expression, implicating these processes in the pathogenesis of keloids.
4 citations
,
July 2024 in “BMC Zoology” This study found that the structure and mineral content of dromedary camel hair, specifically the medulla patterns, medulla index, and elemental composition, change with age, revealing differences among camels aged 1 year, 3-5 years, and 8-10 years.
3 citations
,
August 2022 in “Cutis” This review reports that nail changes such as onycholysis, thin nails, and brittleness are associated with thyroid disorders, highlighting their importance in the early diagnosis of these conditions.
August 2019 in “Journal of Investigative Dermatology” This study found that tight junctions extend to the most superficial layer of the stratum granulosum in human skin, challenging previous claims of their limited presence in the epidermis.
47 citations
,
July 1967 in “Science” This study observed morphological changes in scalp hair follicles of humans deprived of protein for 15 days, which suggests potential use in diagnosing protein-calorie malnutrition.
6 citations
,
September 2018 in “ACS applied bio materials” This study provides conclusive evidence of exogenous calcium fatty acid deposits forming between the cuticle layers in hair, affecting its optical and mechanical properties.
35 citations
,
January 2009 in “Indian Journal of Dermatology, Venereology and Leprology” Older adults commonly experience wrinkles, itchy skin, psoriasis, fungal infections, skin growths, grey hair, hair loss, and nail ridging, but no skin cancer was found in this group.
This study found that mild skin injuries in rats, especially those dosed with dihydrotachysterol, lead to mineral deposits in hair follicle tissue within 6-12 hours, as confirmed by chemical and X-ray diffraction analyses.
In this study, researchers observed a high degree of plasticity in somatosensory axons innervating Merkel cells in adult mouse skin, revealing that both epithelial-neural crosstalk and intrinsic neural mechanisms contribute to axonal patterning and remodeling during epithelial homeostasis.
4 citations
,
January 1981 in “PubMed” This study found that medullary cell content in mammal hair evolves from an amorphous form to a biphasic phase, with human and anthropoid hair containing both macrofibrils and microfibrils.
6 citations
,
January 2017 in “Journal of toxicologic pathology” This study suggests that the patchy thickening and reddish discoloration in rabbit skin during the hair cycle may be due to large anagen-phase hair follicles compressing the dermis and increased blood vessels causing redness.
September 1998 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” Hair changes could indicate neurological diseases and help monitor treatment.
1 citations
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January 1993 in “Skin Pharmacology and Physiology” This study found that an extracellular calcium binding site gradient exists in mouse vibrissa and human scalp follicles, but is not significantly affected by hair growth-altering drugs or epidermal growth factor.
14 citations
,
March 2014 in “Experimental and Molecular Pathology” This study found that sulfur mustard affects hair follicles and sebaceous glands in the skin by causing cellular damage, inflammation, and disrupting wound healing processes in hairless mice.
18 citations
,
January 2008 in “Sen'i Gakkaishi” This study observed that repeated perm treatments decrease disulfide bonds in hair due to their conversion largely into cysteic acid, affecting the waving efficiency depending on the reduction agent used.
35 citations
,
September 2003 in “Archives of dermatology” This study proposed that the tiger tail phenomenon in trichothiodystrophy hair is caused by regular undulations of hair fibers, altering the optical properties seen under polarized light.