92 citations
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November 2003 in “The Journals of Gerontology” This study indicated that while testosterone replacement in older men with low testosterone increases muscle mass and strength and reduces fat, its effects on physical function, disability, falls, or fractures remain unclear.
July 2012 in “The Journal of Urology” This abstract reviews testosterone supplementation with and without a dual 5α-reductase inhibitor on fat-free mass in men with suppressed testosterone production and reports no new research findings.
124 citations
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March 2012 in “JAMA” This abstract discusses the unclear role of dihydrotestosterone (DHT) in postembryonic life in marsupials and possibly humans, reporting no new findings.
12 citations
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March 2000 in “Clinical Chemistry” This study found that a daily dose of 50 mg DHEA only slightly increased the urinary testosterone/epitestosterone ratio for a short period, without exceeding the IOC's acceptable limit.
March 2026 in “Mendeley Data” March 2026 in “Mendeley Data” January 2026 in “Mendeley Data” June 2026 in “OSF Preprints (OSF Preprints)”
21 citations
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September 2017 in “Journal of Obstetrics and Gynaecology Research” This meta-analysis found that chromium supplementation was associated with decreased insulin resistance but increased testosterone levels in women with PCOS, with no significant benefits for other metabolic or hormonal indexes.
50 citations
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May 2018 in “International journal of cardiology” This study found associations between genetic predictors of increased testosterone and cardiovascular risk factors, but the implications for testosterone supplementation are unclear due to uncertainties in genetic variant functions.
2 citations
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January 2017 in “Endocrinology” This chapter reviews the clinical effects of androgens like testosterone and its metabolites on various body systems and life stages, but reports no new results.
6 citations
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January 2016 in “Evidence-based complementary and alternative medicine” In this study, saw palmetto supplements showed varied effects on cell growth in vitro and did not significantly inhibit growth in the hamster flank organ model despite a notable trend.
2 citations
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November 2025 in “Nutrition Journal” This study found that an 8-week supplementation with specific probiotic strains improved hormonal markers and oxidative stress while decreasing inflammation in women with PCOS, although clinical symptoms like acne and hirsutism showed no significant improvement compared to the placebo group.
3 citations
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May 2024 in “Frontiers in Physiology” In this study, male rats with spinal cord injury that received either E2 or DHT supplementation both showed restored expression of respiratory neuroplasticity following acute intermittent hypoxia, with E2 also enhancing overall breathing recovery.
81 citations
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May 2019 in “Frontiers in Endocrinology” This study found that administering melatonin for 12 weeks to women with PCOS significantly reduced hirsutism, testosterone, and inflammation markers, while enhancing antioxidant levels compared to a placebo.
7 citations
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January 2018 in “Australian Prescriber” This review discusses the presence of undeclared substances, including androgenic steroids, in sports supplements and emphasizes potential health risks, without providing new results; it advises caution and consultation on supplement use.
February 2024 in “Indian Dermatology Online Journal” This research highlights dermatologists' concerns about the widespread use of sports supplements, noting that nutritional supplements associated with muscle-building and appearance enhancement can lead to dermatological issues like acne and alopecia, while potentially containing harmful substances such as undisclosed anabolic steroids.
June 2022 in “International Journal of Health Sciences (IJHS)” This study found that a nutrition intervention was more effective than nutrition education or medication alone in reducing symptoms of PCOS, with significant improvements in body measurements and testosterone levels.
January 2025 in “Indian Journal of Animal Research” This study observed that herbal feed supplementation in Frieswal breeding bulls improved semen volume and motility, while significantly lowering dihydrotestosterone levels, suggesting a potential mechanism for enhancing semen quality.
December 2023 in “Kiểm nghiệm và An toàn thực phẩm/Kiểm nghiệm và An toàn thực phẩm (online)” This study developed a liquid chromatography with tandem mass spectrometry method to detect sex hormones in health supplements from Hanoi, Vietnam, finding three out of 16 samples contained sex hormones, including banned testosterone at low levels (~0.5 mg/kg).
May 2026 in “Journal of Functional Foods” In this study of women with polycystic ovary syndrome, 12 weeks of daily ginger supplementation significantly reduced total testosterone and improved menstrual irregularities compared to placebo, suggesting potential as a natural therapeutic approach, although larger studies are needed.
3 citations
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August 2020 in “Nutrition Journal” This study found that spinach-derived thylakoid supplementation, combined with a calorie-restricted diet, led to more significant improvements in weight loss and insulin sensitivity in obese women with PCOS than calorie restriction alone.
September 2016 in “Princeton University Press eBooks” The document concludes that understanding health requires considering evolutionary perspectives on reproductive fitness, and recognizing the complexity of factors like diet, testosterone, and sexual orientation.
14 citations
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March 2001 in “Psychiatric Services” This article reviews changes in men's sexual health after midlife, exploring physiologic changes, psychological factors, and various treatment options, but it presents no new clinical results.
6 citations
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June 2000 in “Psychiatric Services” This article discusses the sexual health issues faced by postmenopausal women and highlights the need for more research and tailored treatments, but it reports no new clinical results.
1 citations
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July 2015 in “Cambridge University Press eBooks” Testosterone therapy can improve sexual function in women but long-term safety is unclear.
1 citations
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January 2014 in “Side effects of drugs annual” Hormonal contraceptives and related compounds can increase health risks like thrombosis and affect sexual function.
January 2010 in “Yearbook of Endocrinology” Older men with lower levels of available testosterone are more likely to be frail.