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    Glossary Testosterone Metabolism

    process of breaking down and converting testosterone in the body

    Testosterone metabolism refers to the process by which the body breaks down and converts testosterone, a key male sex hormone, into other substances. This involves enzymes that transform testosterone into dihydrotestosterone (DHT) and estradiol, which play crucial roles in various bodily functions, including hair growth and sexual development. Understanding this process is important for addressing conditions like alopecia, where DHT can contribute to hair loss.

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    1. Testosterone Metabolism in the Skin Archives of dermatology · 1975 · 74 citations
    2. Testosterone metabolism in the skin. A review of its function in androgenetic alopecia, acne vulgaris, and idiopathic hirsutism including recent studies with antiandrogens Archives of Dermatology · 1975 · 43 citations
    3. Different patterns of 5α-reductase expression, cellular distribution, and testosterone metabolism in human follicular dermal papilla cells Biochemical and Biophysical Research Communications · 2008 · 22 citations
    4. Testosterone Metabolism in Human Skin Cells in vitro and Its Interaction with Estradiol and Dutasteride Skin pharmacology and physiology · 2003 · 21 citations
    5. Is the metabolism of testosterone to 5α-dihydrotestosterone required for androgen action in the skin? British Journal of Dermatology · 1982 · 14 citations
    6. Expression of type 1 5α-reductase and metabolism of testosterone in reconstructed human epidermis (SkinEthic®): a new model for screening skin-targeted androgen modulators International Journal of Cosmetic Science · 2000 · 3 citations
    7. 013 Prostaglandin D2 enhances testosterone metabolism by ROS-mediated altered redox potential in keratinocytes Journal of Investigative Dermatology Symposium Proceedings · 2017
    8. The metabolism of testosterone by dermal papilla cells cultured from scalp follicles of men with androgenetic alopecia Journal of Dermatological Science · 1993
    9. Testosterone alters iron metabolism and stimulates red blood cell production independently of dihydrotestosterone American Journal of Physiology-Endocrinology and Metabolism · 2014 · 53 citations
    10. Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride The Journal of Steroid Biochemistry and Molecular Biology · 2012 · 45 citations
    11. Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men Advances in Experimental Medicine and Biology · 2017 · 31 citations
    12. Anabolic and Metabolic Effects of Testosterone and Other Androgens: Direct Effects and Role of Testosterone Metabolic Products Endocrinology · 2017 · 2 citations
    13. Metabolic Syndrome, Hepatic Steatosis and Testosterone: A Matter of Sex Livers · 2024 · 7 citations
    14. In-vivo uptake and metabolism of testosterone by the skin and other tissues of the rat 1982 · 8 citations
    15. ORIGINAL RESEARCH—ENDOCRINOLOGY: Comparison of the Steady‐State Pharmacokinetics, Metabolism, and Variability of a Transdermal Testosterone Patch Versus a Transdermal Testosterone Gel in Hypogonadal Men ˜The œjournal of sexual medicine · 2005 · 38 citations
    16. Clinical and metabolic implications of obesity in prostate cancer: is testosterone a missing link? 2018 · 12 citations
    17. Persistent Poor Metabolic Profile in Postmenopausal Women With Ovarian Hyperandrogenism After Testosterone Level Normalization Journal of the Endocrine Society · 2019 · 8 citations
    18. Modification of testosterone levels with Piptadeniastrum africanum and Cordia plathytyrsa may influence metabolic parameters in Wistar rats Zenodo (CERN European Organization for Nuclear Research) · 2022
    19. Increase in testosterone metabolism in the rat central nervous system by formalin-induced tonic pain Pharmacology Biochemistry and Behavior · 2002 · 11 citations
    20. 697 Prostaglandin D2-enhanced testosterone metabolism in human keratinocytes is mediated by reactive oxygen species Journal of Investigative Dermatology · 2016 · 1 citations
    21. Testosterone therapy for women with low sexual desire: a position statement from the Brazilian Society of Endocrinology and Metabolism Archives of Endocrinology and Metabolism · 2019 · 10 citations
    22. Effects of chronic inhibition of Testosterone metabolism on cardiac remodeling after ischemia/reperfusion-induced myocardial damage in gonadectomized rats Biology open · 2019 · 4 citations
    23. [Clinical significance of testosterone and dihydrotestosterone metabolism in women]. PubMed · 1996
    24. Clinical relevance of testosterone and dihydrotestosterone metabolism in women ˜The œAmerican journal of medicine · 1995 · 31 citations
    25. Circulating testosterone and feather-gene expression of receptors and metabolic enzymes in relation to melanin-based colouration in the barn owl General and comparative endocrinology · 2017 · 14 citations
    26. In vitro [7-3H]-testosterone metabolism by the rat ventral prostate—Effect of some exogenous compounds Journal of Steroid Biochemistry · 1975 · 12 citations
    27. The Role of Non-Aromatizable Testosterone Metabolite in Metabolic Pathways Physiological Research · 2011 · 21 citations
    28. Testosterone replacement in 49,XXXXY syndrome: andrological, metabolic and neurological aspects Endocrinology, diabetes & metabolism case reports · 2016 · 12 citations
    29. Modification of testosterone levels with Piptadeniastrum africanum and Cordia plathytyrsa may influence metabolic parameters in Wistar rats World Journal of Advanced Research and Reviews · 2022
    30. Testosterone protects female embryonic heart H9c2 cells against severe metabolic stress by activating estrogen receptors and up-regulating IES SUR2B The International Journal of Biochemistry & Cell Biology · 2012 · 24 citations