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Eccrine sweat gland's clear cells likely cause excessive sweating in hyperhidrosis.

Hormonal therapy changes skin and hair in transgender patients, who need better researched dermatologic care.

Using anabolic-androgenic steroids can harm men's reproductive health and increase the risk of heart problems and death.

Blocking 5α-reductase can harm memory and brain structure, and increase harmful brain changes in male mice used for Alzheimer's disease research.

Dihydrotestosterone has a reduced effect on muscle-building in people with testicular feminization syndrome, especially after their gonads are removed.

Hormone therapy in transgender individuals can increase acne and affect hair growth and loss.

The document explains how male reproductive hormones work and affect the body.

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Baldness caused by male hormones in female-to-male transsexuals doesn't increase the risk of heart disease.

Gonadal dysgenesis, like Turner's and Klinefelter's syndromes, negatively affects bone health, but hormone treatments can help.

Muscles can make their own androgens, which may help muscle growth.

5-alpha-reductase inhibitors may cause a low incidence of erectile dysfunction that decreases over time.

Male hormones worsen kidney transplant damage, but blocking them helps.

Hormone imbalances can cause skin diseases, and understanding these links is important for diagnosis and treatment.

The document concludes that hormone therapy is essential for treating gender dysphoria, with specific drugs and monitoring protocols recommended for safety and effectiveness.

Androgen use may increase the risk of stroke, but more research is needed.

Dutasteride, usually used for prostate issues and hair loss, could potentially treat Amyotrophic Lateral Sclerosis (ALS) due to its neuroprotective, antioxidant, and anti-inflammatory properties, but more testing is needed.

The document concludes that respectful, gender-affirming healthcare improves mental health and encourages continued medical care for transgender and non-binary individuals.

Long-term use of finasteride in women can cause hormonal changes, DNA damage, and menstrual issues.

Some supplements and hormones can increase hair loss by raising DHT levels.

Hair transplants help transgender patients look more like their gender identity, with different procedures for trans women and men.

Melatonin applied to the scalp helps increase hair density in people with early hair loss.

Melatonin applied to the scalp helps treat early-stage hair loss in men and women.

The document covers various male health issues, their causes, treatments, and related conditions.

Oxidative stress and immune dysfunction are linked to both Hashimoto's thyroiditis and polycystic ovary syndrome, with diet and specific treatments important for managing these conditions.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

The document concludes that better biomarkers are needed to detect long-term oral testosterone use in athletes.

Testosterone with or without finasteride doesn't improve thinking skills in older men with low testosterone.

Melatonin may help treat PCOS symptoms in rats.