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    Glossary T-helper 2 cell

    immune cell involved in allergic reactions and parasite defense

    A T-helper 2 (Th2) cell is a type of immune cell that plays a crucial role in the body's defense against extracellular parasites, such as helminths, and is also involved in allergic reactions. Th2 cells produce cytokines like IL-4, IL-5, and IL-13, which help stimulate the production of antibodies by B cells and promote the activation of other immune cells.

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    1. 42905 Role of regulatory T and T-helper 17 cells in patients with acute diffuse and total alopecia Journal of the American Academy of Dermatology · 2023
    2. The potential of regulatory T cell-based therapies for alopecia areata Frontiers in Immunology · 2023
    3. A humanized IL-2 fusion protein enhances T regulatory cells in vivo and restrains disease in a murine model of Alopecia Areata 4760 The Journal of Immunology · 2025
    4. Sphingolipid metabolism orchestrates the establishment of the adult hair follicle stem cell niche to control skin homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2024
    5. The role of natural killer cells in autoimmune blistering diseases Autoimmunity · 2011 · 24 citations
    6. Decision letter: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage 2021
    7. The Role of T‐Helper 17 Cells and Regulatory T Cells in Acute Diffuse and Total Alopecia: The Increased Function of Regulatory T Cells May Explain the Favorable Prognosis The Journal of Dermatology · 2025 · 1 citations
    8. Spatial transcriptome reveals disturbance of peri-infundibular immune infiltration in androgenetic alopecia Research Square (Research Square) · 2023
    9. T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities 2018 · 66 citations
    10. The effect of 5-α reductase inhibitor on Th1, Th2, and Th17 cell-related inflammatory response in BPH World Journal of Urology · 2023 · 1 citations
    11. Alopecia areata and risk of atopic and autoimmune conditions: population-based cohort study Clinical and Experimental Dermatology · 2022 · 34 citations
    12. ALOPECIA UNIVERSALIS TREATED WITH ORAL CYCLOSPORINE A AND PREDNISOLONE: IMMUNOLOGIC STUDIES International Journal of Dermatology · 1992 · 26 citations
    13. CLINICAL AND LABORATORY EVALUATION OF AIDS TRICHOPATHY International Journal of Dermatology · 1993 · 35 citations
    14. Reversal of alopecia areata in a mouse model of human hair loss by daily dietary administration of a proprietary extract of North American ginseng (Panax Quinquefolius) 2015
    15. Results of stage I in a phase II randomized bilateral comparison of bexarotene 1% topical gel in alopecia areata Journal of the American Academy of Dermatology · 2005
    16. Imbalance of T‐helper 17 and regulatory T cells in patients with alopecia areata The Journal of Dermatology · 2015 · 62 citations
    17. T helper type 2 immune response in alopecia areata Chinese Journal of Dermatology · 2022
    18. MicroRNA-1246 Inhibits NFATc1 Phosphorylation and Regulates T Helper 17 Cell Activation in the Pathogenesis of Severe Alopecia Areata 2023
    19. Low-Dose IL-2 for Treating Moderate to Severe Alopecia Areata: A 52-Week Multicenter Prospective Placebo-Controlled Study Assessing its Impact on T Regulatory Cell and NK Cell Populations 2020 · 22 citations
    20. Regulatory T Cells: the Many Faces of Foxp3 Journal of Clinical Immunology · 2019 · 125 citations
    21. Antigen-Specific Regulatory T Cells and Low Dose of IL-2 in Treatment of Type 1 Diabetes Frontiers in immunology · 2016 · 23 citations
    22. Silicate-based therapy for inflammatory dilated cardiomyopathy by inhibiting the vicious cycle of immune inflammation via FOXO signaling Science Advances · 2025 · 7 citations
    23. T Cells Promote Distinct Transcriptional Programs of Cutaneous Inflammatory Disease in Keratinocytes and Dermal Fibroblasts Journal of Investigative Dermatology · 2025 · 2 citations
    24. Inhibition of T-cell activity in alopecia areata: recent developments and new directions Frontiers in immunology · 2023 · 4 citations
    25. The function of BST2 in γδ T Cells, CD8 T Cells, and macrophages in alopecia areata pathogenesis 4231 The Journal of Immunology · 2025
    26. Phenotypic Analysis of T-Cells in Extensive Alopecia Areata Scalp Suggests Partial Tolerance 2005 · 21 citations
    27. Modeling cell–cell communication for immune systems across space and time Current Opinion in Systems Biology · 2019 · 20 citations
    28. Human Regulatory T Cells: Understanding the Role of Tregs in Select Autoimmune Skin Diseases and Post-Transplant Nonmelanoma Skin Cancers International Journal of Molecular Sciences · 2023 · 1 citations
    29. Regulatory T cells in dominant immunologic tolerance Journal of Allergy and Clinical Immunology · 2023 · 26 citations
    30. Targeting lymphoid-derived IL-17 signaling to delay skin aging Nature Aging · 2023 · 59 citations