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Aldactone was more effective in reducing hair growth in women with hirsutism than Diane, despite having less impact on hormone levels.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Polycystic Ovary Syndrome is linked to higher risk of hypertension and heart disease.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

Androgens like testosterone affect hair growth and oil production differently across body parts and individuals.

Finasteride for hair loss may cause persistent sexual symptoms, depression, anxiety, and lower quality of life.

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

Skin changes can indicate hormonal imbalances and help diagnose endocrine disorders.

A man with hypoparathyroidism had other health issues that led to a diagnosis of a rare autoimmune disorder, APS-1.

Identifying nonclassic congenital adrenal hyperplasia and carriers of CYP21 mutations is challenging, and genetic counseling is recommended due to their prevalence.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Spironolactone treatment increases the amount of testosterone available in the body.

About 2.2% of women with symptoms of high male hormones have a mild form of congenital adrenal hyperplasia, and measuring a specific hormone level can accurately diagnose it.

Antiandrogens affect androgen-dependent body functions and are used for various medical conditions, with some risks like fetus feminization, but new forms like 17α-propylmesterolone show promise for acne without systemic effects.

Certain genetic variations in the AR and ERβ genes can affect androgen levels in women.

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

Male hormones are important for hair and oil gland development and can cause conditions like excessive hair growth and acne.

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

Different types of androgens bind differently to two receptors, AR1 and AR2, in Atlantic croaker's brain and ovarian tissues, suggesting these receptors may control different androgen actions in fish.

Testosterone therapy may slightly improve sexual function in postmenopausal women, but its long-term safety is unknown.

New compounds may soon be tested to treat excessive hair growth in women.

Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.

Finasteride helps reduce pain and inflammation in animals.

The main enzyme found in pubic skin that could be targeted to treat excessive hair growth is 5 alpha-R2.

Metformin improved menstrual cycle regularity and signs of hyperandrogenism in adolescent girls with type 1 diabetes but did not improve blood sugar control.

MK-386 and finasteride together effectively reduce DHT levels, potentially treating acne and male pattern baldness.

Exposure to too much androgen before birth might cause polycystic ovary syndrome later in life.

Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.

Dihydrotestosterone gel improved well-being and sexual function in older men without negatively affecting prostate health.

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.