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Mutations in the androgen receptor gene cause different levels of androgen insensitivity, making it hard to create simple tests for the condition.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

Cyclosporine A therapy changes sex hormone levels differently in pre-menopausal and post-menopausal women with primary biliary cirrhosis.

Birth control pills help treat skin and hair growth problems linked to high male hormone levels.

A 5 mg dose of transdermal testosterone cream effectively restores testosterone levels in postmenopausal women.

5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.

High testosterone levels in 20% of the women studied may indicate PCOS, while 80% had low levels with potential health impacts.

Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.

Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.

Spironolactone works well for acne and hirsutism, isotretinoin is very effective for acne and may have antiandrogenic effects, and 5 alpha-reductase inhibitors should be considered antiandrogens.

Using two drugs together, Flutamide and 4-MA, is more effective for blocking male hormones than using each one alone.

Cells from balding scalps have more androgen receptors than cells from non-balding scalps.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.

Diagnosing hyperandrogenism in women is complex and requires accurate testing methods and consideration of SHBG levels.

Certain drugs that block specific enzymes can help treat prostate diseases.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Testosterone therapy can improve sexual desire and function in postmenopausal women but should be used cautiously and not based solely on testosterone levels.

Finasteride inhibits enzyme activity in rhesus macaques, suggesting they're useful for evaluating similar drugs.

Testosterone is crucial for development, growth, and various body functions in mammals.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Drospirenone is a unique progestin with anti-water retention and potential blood pressure benefits, used in birth control and hormone therapy.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

Finasteride affects alcohol intake in male mice, possibly due to neurosteroids.

The length of the CAG repeat in the androgen receptor gene affects the risk and progression of prostate cancer, BPH, infertility, and undermasculinized genitalia.

5α-reductase inhibitors and alpha-1 adrenergic antagonists together effectively treat benign prostatic hyperplasia, with long-term benefits.

Insulin resistance is linked to high male hormone levels in women, often seen in those with PCOS.

The study created a test that found hormonal and toxic effects in plant and fungal extracts using prostate cancer cells.