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    Did you mean Small Molecule Inhibitor?
    Glossary Small Molecule Inhibitor

    blocks specific proteins or enzymes within cells

    A Small Molecule Inhibitor (SMI) is a type of drug that can enter cells easily due to its low molecular weight and can interfere with specific proteins or enzymes to block their activity. These inhibitors are often used in treatments for various diseases, including cancer and autoimmune disorders, by targeting and disrupting specific pathways that contribute to disease progression.

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    Research 30 of 1000+

    1. Biologic Therapies and Small-Molecule Inhibitors for Dissecting Cellulitis of the Scalp: A Systematic Review Dermatology and Therapy · 2026
    2. A systematic review of tumor necrosis factor-α blockers, anti-interleukins, and small molecule inhibitors for dissecting cellulitis of the scalp treatment Orphanet Journal of Rare Diseases · 2025
    3. Small Molecule Inhibitors and Inflammatory Skin Diseases Suez Canal University Medical Journal · 2018
    4. 711 Small molecule wnt pathway inhibitor (SM04755) as a potential topical psoriasis treatment Journal of Investigative Dermatology · 2017
    5. A Small Molecule Inhibitor Partitions Two Distinct Pathways for Trafficking of Tonoplast Intrinsic Proteins in Arabidopsis PloS one · 2012 · 35 citations
    6. Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened Clinical cancer research · 2011 · 63 citations
    7. HaCaT‑conditioned medium supplemented with the small molecule inhibitors SB431542 and CHIR99021 and the growth factor PDGF‑AA prevents the dedifferentiation of dermal papilla cells <i>in vitro</i> Molecular Medicine Reports · 2021 · 7 citations
    8. Data from Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened 2023
    9. Biologics and Small Molecules for Inflammatory Nail Disorders: A Narrative Review Indian Dermatology Online Journal · 2024 · 1 citations
    10. A machine learning and network framework to discover new indications for small molecules bioRxiv (Cold Spring Harbor Laboratory) · 2019
    11. New small molecules in dermatology: for the autoimmunity, inflammation and beyond Inflammation Research · 2023 · 9 citations
    12. Biologics and small molecules for patients with concomitant alopecia areata and vitiligo: A review International Journal of Dermatology · 2024
    13. High-throughput screening of small molecule Wnt/β-catenin activators for hair and nail growth Communications Biology · 2026
    14. Stimulation of Hair Growth by Small Molecules that Activate Autophagy Cell reports · 2019 · 88 citations
    15. Modulating Aging and Aging-related Symptoms Using Endogenous Small Molecules 2019
    16. A machine learning and network framework to discover new indications for small molecules PLOS Computational Biology · 2020 · 8 citations
    17. Targeting the Wnt pathways for therapies Molecular and cellular therapies · 2014 · 112 citations
    18. The roles of Wnt/β‐catenin pathway in tissue development and regenerative medicine Journal of Cellular Physiology · 2017 · 89 citations
    19. Editorial: Crosstalk: skin cells and immune cells in inflammatory skin diseases Frontiers in Immunology · 2024 · 3 citations
    20. Recent Advances in Drug Development for Hair Loss International Journal of Molecular Sciences · 2025
    21. Editorial: Targeted immunological therapies in dermatology Frontiers in Medicine · 2024
    22. 1359 Hair growth is induced by blockade of macrophage-derived oncostatin M and downstream JAK-STAT5 signaling in hair follicle stem cells Journal of Investigative Dermatology · 2018
    23. AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma Nature Communications · 2020 · 60 citations
    24. Editorial: Exploring innovative therapies for rare inflammatory skin diseases Frontiers in Medicine · 2026
    25. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012 · 85 citations
    26. Mechanisms of autophagy and their implications in dermatological disorders Frontiers in Immunology · 2024 · 6 citations
    27. Wnt/β‐catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration The FASEB Journal · 2016 · 94 citations
    28. 865 Conditional ablation of JAK-STAT5 signaling induces anagen hair growth Journal of Investigative Dermatology · 2017
    29. Chemotherapy-induced iatrogenic injury of skin: New drugs and new concepts Clinics in Dermatology · 2011 · 19 citations
    30. New developments in the molecular treatment of ichthyosis: review of the literature Orphanet journal of rare diseases · 2022 · 21 citations