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    Did you mean Small Interfering RNA?
    Glossary Small Interfering RNA

    molecule that silences specific genes by degrading their mRNA

    Small Interfering RNA (siRNA) is a type of molecule that can silence or "turn off" specific genes within a cell. It works by binding to a complementary messenger RNA (mRNA) sequence, leading to its degradation and preventing the production of the corresponding protein. This mechanism is often used in research and therapeutic applications to study gene function or to target and reduce the expression of disease-related genes.

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    Research 30 of 1000+

    1. The Circular RNA CircCOL1A1 Functions as a miR-149-5p Sponge to Regulate the Formation of Superior-Quality Brush Hair via the CMTM3/AR Axis Frontiers in cell and developmental biology · 2022 · 3 citations
    2. Keratin disorders: from gene to therapy 2011 · 109 citations
    3. Advances in transdermal siRNAs delivery: A review of current research progress Non-coding RNA Research · 2023 · 20 citations
    4. Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75 Journal of Investigative Dermatology · 2015 · 6 citations
    5. Efficient Silencing of Androgen Receptor Gene via UTR-Targeting siRNAs for Androgenetic Alopecia Therapy Journal of Medicinal Chemistry · 2025
    6. Efficient Silencingof Androgen Receptor Gene viaUTR-Targeting siRNAs for Androgenetic Alopecia Therapy OPAL (Open@LaTrobe) (La Trobe University) · 2025
    7. Genomic Markers and Personalized Medicine in Androgenetic Alopecia: A Comprehensive Review Cosmetics · 2024
    8. Efficacy of Asymmetric siRNA Targeting Androgen Receptors for the Treatment of Androgenetic Alopecia Molecular Pharmaceutics · 2022
    9. Inhibition of Cholesterol Biosynthesis Modulates Epithelial-Mesenchymal Transition in Primary Cicatricial Alopecia Through TGFβ and Angiotensin Receptors Journal of Endocrinology and Reproduction · 2023
    10. Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia (Alopecia Areata) in a C3H/HeJ Mouse Model ˜The œAmerican journal of pathology · 2008 · 69 citations
    11. Histidine decarboxylase expression influences the neofolliculogenesis of newborn mouse dermal cells Journal of Dermatological Science · 2012 · 2 citations
    12. DKK1-targeting cholesterol-modified siRNA implication in hair growth regulation Biochemical and Biophysical Research Communications · 2023 · 1 citations
    13. Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders Frontiers in Immunology · 2020 · 20 citations
    14. Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities Signal Transduction and Targeted Therapy · 2022 · 318 citations
    15. Delivery Strategies of siRNA Therapeutics for Hair Loss Therapy International Journal of Molecular Sciences · 2024 · 1 citations
    16. Transposon control as a checkpoint for tissue regeneration Development · 2022 · 14 citations
    17. Hair Coloration by Gene Regulation: Fact or Fiction? Trends in biotechnology · 2015 · 15 citations
    18. Cutaneous Drug Delivery: An Update Journal of Investigative Dermatology Symposium Proceedings · 2013 · 25 citations
    19. Targeting the Wnt pathways for therapies Molecular and cellular therapies · 2014 · 112 citations
    20. A symphony of signals: the intricate role of lncRNAs in dermatological disorders Clinical and Experimental Medicine · 2025 · 1 citations
    21. The Immune Functions of Keratinocytes in Skin Wound Healing International Journal of Molecular Sciences · 2020 · 147 citations
    22. Comprehensive analysis of circRNAs from cashmere goat skin by next generation RNA sequencing (RNA-seq) Scientific Reports · 2020 · 39 citations
    23. Identification of Biomarkers in Affected Hair Follicles from Chronic Discoid Lupus Erythematosus by Weighted Gene Co-Expression Network Analysis Research Square (Research Square) · 2022
    24. Th1 effector CD4 T cells rely on IFN-γ production to induce alopecia areata 2025
    25. The Molecular Revolution in Cutaneous Biology: Noncoding RNAs: New Molecular Players in Dermatology and Cutaneous Biology Journal of Investigative Dermatology · 2017 · 22 citations
    26. The influence of interferon on healthy and diseased skin Cytokine · 2018 · 32 citations
    27. Regulatory Effects of FGF9 on Dermal Papilla Cell Proliferation in Small-Tailed Han Sheep Genes · 2023
    28. Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One Journal of Medicinal Chemistry · 2022 · 10 citations
    29. Regulation of cashmere fineness traits by noncoding RNA in Jiangnan cashmere goats BMC Genomics · 2023 · 7 citations
    30. The Roles of Non-coding RNA in the Development and Regeneration of Hair Follicles: Current Status and Further Perspectives Frontiers in Cell and Developmental Biology · 2021 · 11 citations