Search

for
Search:

Did you mean Small Interfering RNA?

Glossary Small Interfering RNA

molecule that silences specific genes by degrading their mRNA

Small Interfering RNA (siRNA) is a type of molecule that can silence or "turn off" specific genes within a cell. It works by binding to a complementary messenger RNA (mRNA) sequence, leading to its degradation and preventing the production of the corresponding protein. This mechanism is often used in research and therapeutic applications to study gene function or to target and reduce the expression of disease-related genes.

Related Terms

Sort by

Research

30 / 1000+ results

The Circular RNA CircCOL1A1 Functions as a miR-149-5p Sponge to Regulate the Formation of Superior-Quality Brush Hair via the CMTM3/AR Axis

research The Circular RNA CircCOL1A1 Functions as a miR-149-5p Sponge to Regulate the Formation of Superior-Quality Brush Hair via the CMTM3/AR Axis

3 citations , February 2022 in “Frontiers in cell and developmental biology”

This study found that the circular RNA circCOL1A1 influences the formation of superior-quality brush hair in white goats by regulating hair follicle stem cell behavior and interacting with the miR-149-5p/CMTM3/AR axis.

research Keratin disorders: from gene to therapy

109 citations , September 2011 in “Human molecular genetics online/Human molecular genetics”

This review discusses keratin disorders and potential RNA interference therapeutics, reporting no new clinical findings but highlighting the promise of siRNA for future treatments.

research Advances in transdermal siRNAs delivery: A review of current research progress

20 citations , May 2023 in “Non-coding RNA Research”

This review discusses recent advancements in developing delivery systems for small interfering RNA (siRNA) to treat skin conditions, highlighting innovations like liposomes, dendrimers, cell-penetrating peptides, and spherical nucleic acid nanoparticles designed to overcome challenges of skin permeability and degradation.

research Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75

6 citations , September 2015 in “Journal of Investigative Dermatology”

This study demonstrated that RNA interference targeting mutant keratin genes can effectively correct hair shaft structural defects in a mouse model by reducing mutant gene expression.

research Efficient Silencing of Androgen Receptor Gene via UTR-Targeting siRNAs for Androgenetic Alopecia Therapy

September 2025 in “Journal of Medicinal Chemistry”

This study evaluated a chemically modified siRNA, AR-27 E-Chol, which effectively promoted hair regrowth and reduced androgen receptor gene expression in a DHT-induced mouse model of androgenetic alopecia, suggesting its potential as a novel therapeutic candidate.

research Efficient Silencingof Androgen Receptor Gene viaUTR-Targeting siRNAs for Androgenetic Alopecia Therapy

September 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

This study found that a chemically modified small-interfering RNA candidate, AR-27 E-Chol, effectively stimulated hair regrowth and reduced androgen receptor gene expression in a mouse model of androgenetic alopecia, indicating its potential as a novel therapeutic approach.

research Genomic Markers and Personalized Medicine in Androgenetic Alopecia: A Comprehensive Review

August 2024 in “Cosmetics”

This review discusses genetic and pharmacogenetic insights, along with RNA interference technologies, for developing personalized therapies for androgenetic alopecia, yet presents no new clinical results.

research Efficacy of Asymmetric siRNA Targeting Androgen Receptors for the Treatment of Androgenetic Alopecia

November 2022 in “Molecular Pharmaceutics”

This study found that intradermal injection of a cell-penetrating, AR-targeting asiRNA promoted hair growth and reduced androgen receptor expression in mouse models of androgenetic alopecia, suggesting its therapeutic potential.

Inhibition of Cholesterol Biosynthesis Modulates Epithelial-Mesenchymal Transition in Primary Cicatricial Alopecia Through TGFβ and Angiotensin Receptors

research Inhibition of Cholesterol Biosynthesis Modulates Epithelial-Mesenchymal Transition in Primary Cicatricial Alopecia Through TGFβ and Angiotensin Receptors

May 2023 in “Journal of Endocrinology and Reproduction”

This study found that in primary cicatricial alopecia, reducing cholesterol production and targeting EMT modulators like PPARγ, AhR, AGTR, and TGFβ with siRNA may help mitigate hair follicle damage by modulating epithelial-mesenchymal transition, suggesting potential therapeutic strategies for slowing PCA progression.

research Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia (Alopecia Areata) in a C3H/HeJ Mouse Model

69 citations , February 2008 in “The American journal of pathology”

This study found that local injections of interleukin-4 and neutralizing anti-interferon-γ antibody effectively treated alopecia in a mouse model, suggesting potential therapeutic pathways for human alopecia areata.

research Histidine decarboxylase expression influences the neofolliculogenesis of newborn mouse dermal cells

2 citations , June 2012 in “Journal of Dermatological Science”

This study found that histidine decarboxylase is crucial for the hair-inducing ability of newborn mouse dermal cells, with its expression significantly decreasing in the first few days after birth.

research DKK1-targeting cholesterol-modified siRNA implication in hair growth regulation

1 citations , May 2023 in “Biochemical and Biophysical Research Communications”

This study found that DKK1-targeting siRNA, which may activate the Wnt/β-catenin signaling pathway, showed hair growth results in mice similar to those treated with the FDA-approved minoxidil, suggesting potential as an androgenetic alopecia therapy.

research Exosomes facilitate mRNA and siRNA delivery using cationic liposomes 2X3-DOPE to rat heart mesenchymal cells in vitro

June 2025 in “Medical academic journal”

The study found that hybrid nanoparticles incorporating exosomes with cationic liposomes 2X3-DOPE significantly improved the delivery of both messenger RNA and small interfering RNA to rat cardiac mesenchymal stem cells in vitro, achieving up to 100% transfection efficiency for small interfering RNA.

research Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders

20 citations , December 2020 in “Frontiers in Immunology”

This study found that certain T cell-associated genes were upregulated in dogs with Vogt-Koyanagi-Harada syndrome and vitiligo, suggesting a shared immunopathogenesis with humans.

Wnt/β-Catenin Signaling: Function, Biological Mechanisms, and Therapeutic Opportunities

research Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

318 citations , January 2022 in “Signal Transduction and Targeted Therapy”

This study systematically reviews the Wnt/β-catenin signaling pathway, discussing its origin, composition, function, involvement in tumors and diseases, and the development of small-molecular compounds targeting this pathway for disease treatment.

research Delivery Strategies of siRNA Therapeutics for Hair Loss Therapy

1 citations , July 2024 in “International Journal of Molecular Sciences”

In this review, researchers introduced clinically tunable siRNA delivery systems for hair loss treatment, discussing design principles and analyzing relevant clinical trials to propose a framework for optimizing siRNA delivery in a clinical context.

research Transposon control as a checkpoint for tissue regeneration

14 citations , November 2022 in “Development”

This review discusses how transposable element activation may hinder tissue regeneration and explores mechanisms to control this activity, reporting no new experimental results.

research The influence of interferon on healthy and diseased skin

32 citations , December 2018 in “Cytokine”

This review discusses the involvement of type I interferons in skin autoimmune and inflammatory diseases but reports no new clinical results.

research Therapeutic small extracellular vesicles from key human stem and immune cellular sources: A review

January 2026 in “Journal of Biomedical Research”

This review discusses the potential of small extracellular vesicles (sEVs) as next-generation therapeutics, noting their ability to overcome biological barriers and modulate cellular environments for various diseases.

research Hair Coloration by Gene Regulation: Fact or Fiction?

15 citations , November 2015 in “Trends in biotechnology”

This article discusses strategies for changing hair color by regulating target genes in hair follicles using advanced delivery systems, but it reports no new experimental findings.

research Cutaneous Drug Delivery: An Update

25 citations , December 2013 in “Journal of Investigative Dermatology Symposium Proceedings”

This review discusses recent advancements in cutaneous drug delivery technologies and the potential of transfollicular pathways for improved treatment of skin conditions, but reports no clinical results.

research Targeting the Wnt pathways for therapies

112 citations , January 2014 in “Molecular and cellular therapies”

This review summarizes the current understanding of Wnt signaling in relation to its roles in tissue regeneration and cancer progression and discusses recent medical advancements targeting this pathway for therapeutic purposes.

research Formation of the cornified envelope

3 citations , September 2005 in “Experimental dermatology”

This review discusses the formation and structure of the cornified cell envelope in the epidermis, highlighting biochemical pathways and genetic factors, but presents no new experimental results.

Screening and Identification of LncRNAs Related to Villus Growth of Liaoning Cashmere Goats and Their Effects on Growth After FGF5 Treatment

research Screening and Identification of LncRNAs Related to Villus Growth of Liaoning Cashmere Goats and Their Effects on Growth after FGF5 Treatment

August 2019 in “Research Square (Research Square)”

This study explored how long non-coding RNA mediates the effects of FGF5 on the hair follicle development and villus growth of Liaoning cashmere goats.

research A symphony of signals: the intricate role of lncRNAs in dermatological disorders

1 citations , November 2025 in “Clinical and Experimental Medicine”

This review highlights the emerging role of long non-coding RNAs (lncRNAs) in dermatology, suggesting that lncRNAs significantly impact signaling pathways involved in normal skin functions and skin diseases, offering potential as biomarkers and therapeutic targets.

research Somatostatin Expression in Human Hair Follicles and Its Potential Role in Immune Privilege

27 citations , January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study identified somatostatin as a potential secretory factor contributing to the immune privilege of human hair follicles.

research The Immune Functions of Keratinocytes in Skin Wound Healing

147 citations , November 2020 in “International Journal of Molecular Sciences”

This review discusses the immune roles of keratinocytes in wound healing and chronic wound inflammation, emphasizing their potential impact on chronic wound pathology and highlighting areas for future research.

research Novel TMEM173 Mutation and the Role of Disease Modifying Alleles

47 citations , December 2019 in “Frontiers in immunology”

This study identified a novel G207E STING mutation associated with severe inflammatory symptoms and suggested that common polymorphisms in TMEM173 and IFIH1 may modify the phenotype in affected individuals.

research Comprehensive analysis of circRNAs from cashmere goat skin by next generation RNA sequencing (RNA-seq)

39 citations , January 2020 in “Scientific Reports”

This study identified four circRNAs with significantly different expression levels in Liaoning cashmere goats, suggesting a potential role in regulating cashmere fineness.

research Future Directions in the Treatment of Vitiligo

3 citations , March 2018

This chapter reviews recent developments in vitiligo research, highlighting the role of melanocyte stem cell differentiation and oxidative stress in its management, but reports no new clinical results.