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    Did you mean Small Interfering RNA?
    Glossary Small Interfering RNA

    molecule that silences specific genes by degrading their mRNA

    Small Interfering RNA (siRNA) is a type of molecule that can silence or "turn off" specific genes within a cell. It works by binding to a complementary messenger RNA (mRNA) sequence, leading to its degradation and preventing the production of the corresponding protein. This mechanism is often used in research and therapeutic applications to study gene function or to target and reduce the expression of disease-related genes.

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    Research 30 of 1000+

    1. The Circular RNA CircCOL1A1 Functions as a miR-149-5p Sponge to Regulate the Formation of Superior-Quality Brush Hair via the CMTM3/AR Axis Frontiers in cell and developmental biology · 2022 · 3 citations
    2. Keratin disorders: from gene to therapy 2011 · 109 citations
    3. Advances in transdermal siRNAs delivery: A review of current research progress Non-coding RNA Research · 2023 · 20 citations
    4. Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75 Journal of Investigative Dermatology · 2015 · 6 citations
    5. Efficient Silencing of Androgen Receptor Gene via UTR-Targeting siRNAs for Androgenetic Alopecia Therapy Journal of Medicinal Chemistry · 2025
    6. Efficient Silencingof Androgen Receptor Gene viaUTR-Targeting siRNAs for Androgenetic Alopecia Therapy OPAL (Open@LaTrobe) (La Trobe University) · 2025
    7. Genomic Markers and Personalized Medicine in Androgenetic Alopecia: A Comprehensive Review Cosmetics · 2024
    8. Efficacy of Asymmetric siRNA Targeting Androgen Receptors for the Treatment of Androgenetic Alopecia Molecular Pharmaceutics · 2022
    9. Inhibition of Cholesterol Biosynthesis Modulates Epithelial-Mesenchymal Transition in Primary Cicatricial Alopecia Through TGFβ and Angiotensin Receptors Journal of Endocrinology and Reproduction · 2023
    10. Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia (Alopecia Areata) in a C3H/HeJ Mouse Model ˜The œAmerican journal of pathology · 2008 · 69 citations
    11. DKK1-targeting cholesterol-modified siRNA implication in hair growth regulation Biochemical and Biophysical Research Communications · 2023 · 1 citations
    12. Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin Cancer research · 2018 · 34 citations
    13. Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders Frontiers in Immunology · 2020 · 20 citations
    14. Exosomes facilitate mRNA and siRNA delivery using cationic liposomes 2X3-DOPE to rat heart mesenchymal cells <i>in vitro</i> Medical academic journal · 2025
    15. Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities Signal Transduction and Targeted Therapy · 2022 · 318 citations
    16. Delivery Strategies of siRNA Therapeutics for Hair Loss Therapy International Journal of Molecular Sciences · 2024 · 1 citations
    17. Transposon control as a checkpoint for tissue regeneration Development · 2022 · 14 citations
    18. Targeting the Wnt pathways for therapies Molecular and cellular therapies · 2014 · 112 citations
    19. A symphony of signals: the intricate role of lncRNAs in dermatological disorders Clinical and Experimental Medicine · 2025 · 1 citations
    20. Th1 effector CD4 T cells rely on IFN-γ production to induce alopecia areata 2025
    21. The Molecular Revolution in Cutaneous Biology: Noncoding RNAs: New Molecular Players in Dermatology and Cutaneous Biology Journal of Investigative Dermatology · 2017 · 22 citations
    22. The influence of interferon on healthy and diseased skin Cytokine · 2018 · 32 citations
    23. A Proposed Microneedle–Small Extracellular Vesicle System for Localized Adjunctive Treatment of Established Oral Squamous Cell Carcinoma: A Narrative Review and Preclinical Development Perspective Cells · 2026
    24. Regulatory Effects of FGF9 on Dermal Papilla Cell Proliferation in Small-Tailed Han Sheep Genes · 2023
    25. Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One Journal of Medicinal Chemistry · 2022 · 10 citations
    26. Regulation of cashmere fineness traits by noncoding RNA in Jiangnan cashmere goats BMC Genomics · 2023 · 7 citations
    27. The Roles of Non-coding RNA in the Development and Regeneration of Hair Follicles: Current Status and Further Perspectives Frontiers in Cell and Developmental Biology · 2021 · 11 citations
    28. Plucked hair follicles from patients with chronic discoid lupus erythematosus show a disease-specific molecular signature Lupus Science & Medicine · 2019 · 17 citations
    29. Comprehensive transcriptome and methylome analysis delineates the biological basis of hair follicle development and wool-related traits in Merino sheep BMC Biology · 2021 · 112 citations
    30. Circulating MicroRNA Signatures in Severe Alopecia Areata: Diagnostic Discrimination, Pathway Analysis, and Therapeutic Implications Preprints.org · 2025