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    Glossary Small Molecules

    low-weight compounds that easily enter cells to regulate processes

    Small molecules are low molecular weight organic compounds that can easily enter cells due to their small size. They are often used in medicine to regulate biological processes, including the treatment of diseases like cancer and alopecia, by interacting with specific proteins or enzymes within the body.

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    1. Small molecules and small molecule drugs in regenerative medicine Drug Discovery Today · 2013 · 51 citations
    2. Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives Cells · 2020 · 24 citations
    3. Small Molecule Treatments Improve Differentiation Potential of Human Amniotic Fluid Stem Cells Frontiers in Bioengineering and Biotechnology · 2021 · 11 citations
    4. Small molecules facilitate single factor-mediated sweat gland cell reprogramming Military Medical Research · 2022 · 9 citations
    5. New small molecules in dermatology: for the autoimmunity, inflammation and beyond Inflammation Research · 2023 · 9 citations
    6. A machine learning and network framework to discover new indications for small molecules PLOS Computational Biology · 2020 · 8 citations
    7. Game Changers: Blockbuster Small-Molecule Drugs Approved by the FDA in 2024 Pharmaceuticals · 2025 · 8 citations
    8. Biologics and Small Molecule Targeted Therapies for Pediatric Alopecia Areata, Psoriasis, Atopic Dermatitis, and Hidradenitis Suppurativa in the US: A Narrative Review Children · 2024 · 8 citations
    9. The Binding of Small Molecules and Polymers to Keratin and Their Effects on the Physicochemical and Surface Properties of Hair Fibers Springer eBooks · 1981 · 7 citations
    10. Biologics and Small Molecules for Inflammatory Nail Disorders: A Narrative Review Indian Dermatology Online Journal · 2024 · 1 citations
    11. Novel small molecules downregulate CDK1 expression and inhibit Wnt/β-catenin signaling in cutaneous squamous cell carcinoma by targeting its distinct tumor-specific cellular landscape Experimental & Molecular Medicine · 2025
    12. Biologics and small molecules for patients with concomitant alopecia areata and vitiligo: A review International Journal of Dermatology · 2024
    13. A machine learning and network framework to discover new indications for small molecules bioRxiv (Cold Spring Harbor Laboratory) · 2019
    14. Small Molecules Accelerate Skin Wound Healing: Shikonin Efficacy and Mechanism of Action in Mice International Journal of Morphology · 2024
    15. Biologic Therapies and Small-Molecule Inhibitors for Dissecting Cellulitis of the Scalp: A Systematic Review Dermatology and Therapy · 2026
    16. A Paintable Small-Molecule Hydrogel with Antimicrobial and ROS Scavenging Activities for Burn Wound Healing Gels · 2024
    17. Small Molecule Inhibitors and Inflammatory Skin Diseases Suez Canal University Medical Journal · 2018
    18. Sequential small-molecule therapy for lymphocytic cicatricial alopecia: A multicenter prospective cohort pilot study Journal of the American Academy of Dermatology · 2026
    19. A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming Experimental and Molecular Medicine · 2018 · 19 citations
    20. A systematic review of tumor necrosis factor-α blockers, anti-interleukins, and small molecule inhibitors for dissecting cellulitis of the scalp treatment Orphanet Journal of Rare Diseases · 2025
    21. Small Molecule Agents Against Alopecia: Potential Targets and Related Pathways European Journal of Medicinal Chemistry · 2024
    22. 711 Small molecule wnt pathway inhibitor (SM04755) as a potential topical psoriasis treatment Journal of Investigative Dermatology · 2017
    23. Synthesis and biological screening of small molecule peptides based on the amino acid sequence of thymosin β4 2015
    24. A Small Molecule Inhibitor Partitions Two Distinct Pathways for Trafficking of Tonoplast Intrinsic Proteins in Arabidopsis PloS one · 2012 · 35 citations
    25. A microscopy-based small molecule screen in primary neurons reveals neuroprotective properties of the FDA-approved anti-viral drug Elvitegravir Molecular Brain · 2020 · 3 citations
    26. Bioactive Small Molecule Enhances Skin Burn Wound Healing and Hair Follicle Regeneration by Activating PI3K/AKT Signaling Pathway: A Preclinical Evaluation in Animal Model Journal of Biomedical Nanotechnology · 2022
    27. On Pathways for Small Molecules Into and Out of Human Hair Fibers Journal of Forensic Sciences · 1996 · 56 citations
    28. Effective holistic characterization of small molecule effects using heterogeneous biological networks Frontiers in Pharmacology · 2023 · 11 citations
    29. HaCaT‑conditioned medium supplemented with the small molecule inhibitors SB431542 and CHIR99021 and the growth factor PDGF‑AA prevents the dedifferentiation of dermal papilla cells <i>in vitro</i> Molecular Medicine Reports · 2021 · 7 citations
    30. A perspective on small molecules targeting the renin–angiotensin–aldosterone system and their utility in cardiovascular diseases: exploring the structural insights for rational drug discovery and development RSC Medicinal Chemistry · 2025 · 6 citations