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    Did you mean Small Molecule Inhibitor?
    Glossary Small Molecule Inhibitor

    blocks specific proteins or enzymes within cells

    A Small Molecule Inhibitor (SMI) is a type of drug that can enter cells easily due to its low molecular weight and can interfere with specific proteins or enzymes to block their activity. These inhibitors are often used in treatments for various diseases, including cancer and autoimmune disorders, by targeting and disrupting specific pathways that contribute to disease progression.

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    Research 30 of 1000+

    1. A systematic review of tumor necrosis factor-α blockers, anti-interleukins, and small molecule inhibitors for dissecting cellulitis of the scalp treatment Orphanet Journal of Rare Diseases · 2025
    2. Biologic Therapies and Small-Molecule Inhibitors for Dissecting Cellulitis of the Scalp: A Systematic Review Dermatology and Therapy · 2026
    3. Small Molecule Inhibitors and Inflammatory Skin Diseases Suez Canal University Medical Journal · 2018
    4. Biologics and Small Molecules for Inflammatory Nail Disorders: A Narrative Review Indian Dermatology Online Journal · 2024 · 1 citations
    5. New small molecules in dermatology: for the autoimmunity, inflammation and beyond Inflammation Research · 2023 · 9 citations
    6. Biologics and small molecules for patients with concomitant alopecia areata and vitiligo: A review International Journal of Dermatology · 2024
    7. 865 Conditional ablation of JAK-STAT5 signaling induces anagen hair growth Journal of Investigative Dermatology · 2017
    8. 1359 Hair growth is induced by blockade of macrophage-derived oncostatin M and downstream JAK-STAT5 signaling in hair follicle stem cells Journal of Investigative Dermatology · 2018
    9. Editorial: Exploring innovative therapies for rare inflammatory skin diseases Frontiers in Medicine · 2026
    10. Recent Advances in Drug Development for Hair Loss International Journal of Molecular Sciences · 2025
    11. Editorial: Targeted immunological therapies in dermatology Frontiers in Medicine · 2024
    12. Mechanisms of autophagy and their implications in dermatological disorders Frontiers in Immunology · 2024 · 6 citations
    13. Game Changers: Blockbuster Small-Molecule Drugs Approved by the FDA in 2024 Pharmaceuticals · 2025 · 8 citations
    14. Modern Therapies for Discoid Lupus Erythematosus: A Narrative Review Dermatology and Therapy · 2026
    15. Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases Frontiers in immunology · 2019 · 88 citations
    16. The Effect of JAK Inhibitor on the Survival, Anagen Re-Entry, and Hair Follicle Immune Privilege Restoration in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2020 · 16 citations
    17. JAK-STAT pathway-associated skin diseases: a refined functional framework for inflammatory skin diseases Frontiers in Immunology · 2026
    18. The emerging role of Janus kinase inhibitors in the treatment of autoimmune and inflammatory diseases 2020 · 70 citations
    19. Alopecia Areata Springer eBooks · 2017 · 1 citations
    20. An overview of JAK/STAT pathways and JAK inhibition in alopecia areata Frontiers in immunology · 2022 · 40 citations
    21. Tofacitinib citrate alleviates alopecia universalis symptoms in recent case study Journal of the American Academy of Dermatology · 2016
    22. Rapidly Progressive Alopecia Universalis after Varicella-Zoster Virus Infection: The role of Immune Dysregulation and Tofacitinib treatment 2025
    23. Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders Frontiers in Immunology · 2020 · 20 citations
    24. Stimulation of Hair Growth by Small Molecules that Activate Autophagy Cell reports · 2019 · 88 citations
    25. Understanding the Role of Type I Interferons in Cutaneous Lupus and Dermatomyositis: Toward Better Therapeutics Arthritis & Rheumatology · 2024 · 14 citations
    26. SOCS1 and SOCS3 as key checkpoint molecules in the immune responses associated to skin inflammation and malignant transformation Frontiers in Immunology · 2024 · 26 citations
    27. New developments in the molecular treatment of ichthyosis: review of the literature Orphanet journal of rare diseases · 2022 · 21 citations
    28. Theoretical investigation on the construction of hair follicle membranes and the transdermal drug delivery mechanisms of JAK inhibitors via distinct pathways Colloids and Surfaces A Physicochemical and Engineering Aspects · 2026
    29. JAK-centric explainable few-shot gene-expression diagnosis framework for alopecia via MultiPLIER priors and relation-style set-to-set comparison Frontiers in Molecular Biosciences · 2026
    30. Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition Nature medicine · 2014 · 701 citations