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    Glossary Skin Fragility

    condition where skin is unusually delicate and easily damaged

    Skin fragility refers to a condition where the skin is unusually delicate and prone to damage, such as tearing, blistering, or bruising, even with minimal trauma. This can be due to genetic disorders, aging, or underlying medical conditions that affect the structural integrity of the skin, such as Ehlers-Danlos syndrome or certain types of epidermolysis bullosa. For professionals, understanding the underlying cause is crucial for managing and treating the condition effectively.

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    1. Histopathological and Ultrastructural Study of Ectodermal Dysplasia/Skin Fragility Syndrome The American Journal of Dermatopathology · 2005 · 31 citations
    2. Homozygous Nonsense Mutation in DSC3 Resulting in Skin Fragility and Hypotrichosis 2020 · 8 citations
    3. 474 Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of keratin 14 and human skin fragility Journal of Investigative Dermatology · 2017
    4. Skin fragility in the wild-derived, inbred mouse strain Mus pahari/EiJ Experimental and Molecular Pathology · 2016
    5. Skin fragility, diffuse ecchymosis and blisters on a yellowish waxy base Journal of The American Academy of Dermatology · 2016
    6. Deficient Plakophilin-1 Expression Due to a Mutation in PKP1 Causes Ectodermal Dysplasia-Skin Fragility Syndrome in Chesapeake Bay Retriever Dogs PLoS ONE · 2012 · 28 citations
    7. A Scandinavian case of skin fragility, alopecia and cardiomyopathy caused by<i>DSP</i>mutations Clinical and experimental dermatology · 2013 · 11 citations
    8. Cryptic Patterning of Avian Skin Confers a Developmental Facility for Loss of Neck Feathering PLoS Biology · 2011 · 103 citations
    9. Effects of Skin Lightening Cream Agents – Hydroquinone and Kojic Acid, on the Skin of Adult Female Experimental Rats Clinical Cosmetic and Investigational Dermatology · 2020 · 46 citations
    10. Investigation of age-related decline of microfibril-associated glycoprotein-1 in human skin through immunohistochemistry study Clinical Cosmetic and Investigational Dermatology · 2013 · 15 citations
    11. Congenital and Hereditary Skin Diseases 2018
    12. Skin diseases associated with Agent Orange and other organochlorine exposures. Journal of The American Academy of Dermatology · 2016
    13. Skin Keratins 2015 · 54 citations
    14. The Pathobiology of Skin Aging American Journal Of Pathology · 2020 · 122 citations
    15. Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility 2009 · 189 citations
    16. The dark and the bright sides of the transcription factor Nrf2 in skin protection and disease (Nrf2 and epidermal barrier function) Free Radical Biology and Medicine · 2015
    17. Hyperaldosteronism and Hyperprogesteronism in a Cat Journal of Feline Medicine and Surgery · 2009 · 55 citations
    18. Generalized atrophic benign epidermolysis bullosa. PubMed · 1997 · 51 citations
    19. Mutations in KLHL24 Add to the Molecular Heterogeneity of Epidermolysis Bullosa Simplex Journal of Investigative Dermatology · 2017 · 44 citations
    20. Familial and Sporadic Porphyria Cutanea Tarda Medicine · 2010 · 38 citations
    21. Epidermolysis bullosa in animals: a review Veterinary Dermatology · 2014 · 33 citations
    22. Inherited epidermolysis bullosa: clinical and therapeutic aspects Anais Brasileiros de Dermatologia · 2013 · 32 citations
    23. Dermatoporosis: a further step to recognition Journal of the European Academy of Dermatology and Venereology · 2018 · 20 citations
    24. Cutaneous Toxicities From Transplantation-Related Medications American Journal of Transplantation · 2017 · 14 citations
    25. Porphyria Cutanea Tarda in a Patient With Agnogenic Myeloid Metaplasia Archives of Dermatology · 1984 · 5 citations
    26. Syndromic epidermolysis bullosa simplex subtype due to mutations in the KLHL24 gene: series of case reports in Russian families Frontiers in Medicine · 2024 · 3 citations
    27. Sucessful treatment of feline demodicosis with orally sarolaner Case Report 2020 · 2 citations
    28. Clinical symptoms and sex steroid measurements in domestic ferrets (Mustela putorius furo) with hyperadrenocorticism 2017 · 1 citations
    29. Case of non-Herlitz junctional epidermolysis bullosa with<i>COL17A1</i>mutation The Journal of Dermatology · 2015 · 1 citations
    30. PA11 A rare case of a severe papulopustular dermatosis secondary to a germline <i>EGFR</i> mutation British Journal of Dermatology · 2026