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Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

Androgens cause skin issues like acne and hair growth in women, often due to PCOS, and can be treated with medication and lifestyle changes.

Neurosteroids show promise for treating epilepsy and more research is needed.

The current methods for diagnosing polycystic ovary syndrome are too vague and may lead to misdiagnosis and problems in research.

Products should be called 'sperm-safe' only after thorough, well-designed tests.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

Minoxidil absorbs poorly through skin, with low risk of side effects at 1-2% concentration.

Certain drugs that block specific enzymes can help treat prostate diseases.

Using finasteride or dutasteride may cause long-lasting erectile dysfunction.

Early detection and treatment of PCOS in teenagers is important to manage symptoms and prevent severe issues.

The document concludes with guidance for doctors on diagnosing and treating hirsutism effectively and safely.

Polycystic Ovary Syndrome is common but often undiagnosed, and early treatment is important to prevent health problems.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Autophagy is important for human hair growth and health.

Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.

New methods to make oxasteroids show promise for medical treatments like osteoporosis and breast cancer.

Prolactin may be important for skin growth and immune function.

Some people experience severe, long-lasting side effects from fluoroquinolone antibiotics, leading to the recommendation of limited use and increased awareness of these risks.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

A woman with breast cancer developed a rare condition causing excessive fine hair growth on her face and body.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

APS-1 in Italy shows diverse AIRE mutations and various autoimmune issues.

Hormonal treatments are effective as a second-line option for moderate-to-severe acne in females, but should be used with caution due to health risks.

The document concludes that new treatments are needed to better manage acne and reduce side effects related to current therapies.

The document concludes that managing hirsutism involves identifying the cause, using a scoring system for severity, combining cosmetic and medical treatments, encouraging weight loss, and providing psychological support, while noting the need for more research on drug treatments.

Acne is significantly influenced by genetics, and understanding its genetic basis could lead to better, targeted treatments.

Understanding and tracking our body's natural daily rhythms could help improve heart health.

Hair disorders are caused by a complex mix of biology, genetics, hormones, and environmental factors, affecting hair growth and leading to conditions like alopecia.