January 2011 in “Yearbook of Dermatology and Dermatologic Surgery” Hair relaxers are linked to reduced cystine levels and potential hair damage.
29 citations
,
May 2007 in “British Journal of Dermatology” This report describes five patients who experienced hair loss with discomfort and scarring after undergoing salon hair relaxer treatments, regardless of whether 'lye' or 'no lye' products were used.
12 citations
,
November 2019 in “South African Medical Journal” This study found that the pH levels of relaxers tested were corrosive to the skin and may contribute to alopecia in females with afro-textured hair.
4 citations
,
July 2016 in “Journal of cosmetic dermatology” This review discusses the potential risks and effects of chemical relaxers on hair and scalp health, reporting no new clinical results; the authors emphasize dermatologist guidance to mitigate these issues.
3 citations
,
May 2009 in “International Journal of Cosmetic Science” This study investigated the effects of different relaxer treatments on African-American hair, finding lab-made relaxer solutions caused less damage to hair topography than commercial systems.
1 citations
,
June 2021 in “Preprints.org” This study demonstrated that hair relaxers containing common chemicals significantly reduced cell viability and increased apoptosis in human skin cells, suggesting potential toxicity that could be assessed with advanced in vitro technologies rather than animal testing.
1 citations
,
November 2011 in “Dermatologica Sinica” This study found a significant decline in serum zinc levels among women of African descent using hair relaxers and experiencing alopecia, with age at first exposure potentially influencing alopecia development.
May 2026 in “Journal of Clinical Oncology” This study found no evidence of subtype-specific breast cancer risk associated with hair relaxer use among women in Ghana, though the risk was elevated for former users across all subtypes.
January 2026 in “Psychoneuroendocrinology” Lye relaxers don't significantly change hair cortisol levels.
June 2024 in “Journal of Clinical Oncology” In this study, researchers analyzed data showing that Black women became the racial group with the highest incidence of endometrial cancer starting in 2017, associating frequent use of chemical hair relaxers with an increased risk of this cancer.
February 2019 in “IP Indian journal of clinical and experimental dermatology” In this study, continuous use of chemical hair relaxers and curlers was associated with adverse effects such as hair fall, thinning, and scalp irritation in patients with telogen effluvium.
August 2005 in “Microscopy and Microanalysis” Polymethylene wax in hair relaxers makes hair smooth and shiny with less damage.
1 citations
,
August 2020 in “British Journal of Dermatology” Caffeine may protect hair follicles from stress-related hair loss.
June 2023 in “Journal of the American Academy of Dermatology” This study reviewed existing research on the potential link between chemical hair relaxers and uterine cancer, highlighting the scarcity of epidemiological studies and stressing the importance of understanding straightening methods in communities of color.
25 citations
,
August 2015 in “Journal of cosmetic dermatology” This study observed significant differences in hair care practices and biologic hair parameters between Caucasian and African American women, which may contribute to varying hair fragility and growth.
11 citations
,
January 2000 in “Journal of cosmetic science” This study found that hydrolyzed wheat proteins extensively penetrated both untreated and chemically treated hair, primarily occupying areas like the endocuticle and cortex.
2 citations
,
January 2011 This study found that the primary mechanism behind hair relaxation in Afro-hair is the alkali-induced denaturation of helical filaments, leading to spontaneous straightening.
March 2010 in “Cosmetic Dermatology” Hair straightening methods have advanced to improve effectiveness and reduce damage, but still rely on heat and chemicals.
July 2012 in “Springer eBooks” The document concludes that proper diagnosis and treatment of nonscarring alopecias can improve quality of life and hair regrowth is possible as the hair follicle remains intact.
June 2007 in “Journal of Investigative Dermatology” Title change to "Central Centrifugal Cicatricial Alopecia (CCCA)"; common in African American women; hair-grooming methods may contribute; no effective therapy found; trials needed.
148 citations
,
April 2018 in “Environmental Research” This study found that hair products used by Black women and children in the U.S. contain multiple chemicals associated with endocrine disruption and asthma, highlighting potential exposure disparities and a need for improved labeling.
88 citations
,
April 2011 in “Archives of Dermatology” This study found a high prevalence of central hair loss among African American women and associated it with diabetes mellitus type 2, bacterial scalp infections, and hairstyles causing traction.
75 citations
,
March 2009 in “Journal of The American Academy of Dermatology” This review discusses the evolution and ongoing debate about the causes of central centrifugal cicatricial alopecia in African American women, without presenting new clinical findings.
60 citations
,
April 2018 in “Clinical, cosmetic and investigational dermatology” This review discusses the causes and diagnosis of traction alopecia, emphasizing education for high-risk populations as there is currently no cure, and presents no new clinical findings.
57 citations
,
September 2005 in “International Journal of Dermatology” This study reported that chemical relaxants and hair styling practices were associated with scarring hair loss, particularly among women with central centrifugal cicatricial alopecias.
55 citations
,
March 2007 in “Journal of cosmetic dermatology” This review discusses the historical development of hair straightening products for Afro-ethnic hair and reports no new research findings.
55 citations
,
October 2003 in “Dermatologic Clinics” This article discusses the complexities of treating hair and scalp disorders in African American patients, emphasizing the importance of understanding their specific hair care practices and the unique impact on quality of life, but reports no new empirical findings.
17 citations
,
January 2015 in “Current problems in dermatology” This chapter reviews cultural practices and morphological differences in ethnic hair, relating them to specific disorders seen in these populations, without presenting new clinical results.
13 citations
,
June 2021 in “Carcinogenesis” In this study, frequent use of hair straighteners/relaxers and pressing products was associated with an increased risk of ovarian cancer, with potential variation in risk by tumor type noted for permanent hair dyes.
8 citations
,
October 2014 in “Journal of analytical toxicology.” This study found that a single application of 'Lye' or 'No-Lye' chemical straighteners significantly reduced drug concentrations in hair samples from both drug-fortified standards and authentic drug users.