14 citations
,
July 2010 in “Experimental Dermatology” A new mutation in the HR gene causes hair loss in a specific family.
November 2025 in “Journal of Investigative Dermatology” Radiation-induced hair loss may be caused by hair growth stopping and inflammation in blood vessels.
This article suggests that alopecia areata may be an early skin manifestation of hereditary hemochromatosis in individuals predisposed to autoimmunity, recommending iron status evaluation during AA diagnosis; it reports no new clinical results.
35 citations
,
April 2008 in “Journal of Biological Chemistry” This study found that the lack of expression and deletion of specific hair keratin genes on chromosome 7q36 in Hirosaki hairless rats suggests the crucial role of these genes in hair growth.
9 citations
,
July 2012 in “Dermatitis” Hair dye with para-phenylenediamine can cause skin depigmentation.
6 citations
,
January 2007 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas” This study found that topical application of triiodothyronine (T3) can induce the transition of hair follicles from the telogen to the anagen phase in mice and stimulate hair shaft growth in vitro.
34 citations
,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that androgens influence hair follicle behavior via the dermal papilla, using evidence from human and red deer cells with differing androgen responses as models.
November 2013 in “Institutional Repositories DataBase (IRDB)” In this study, γ-ray irradiation in mice during the first telogen phase led to decreased hair follicle density and pigmentation anomalies, suggesting damage to stem cells and progenitors for keratinocytes and melanocytes.
16 citations
,
January 2018 in “International journal of trichology” This study observed that individuals with premature hair graying had lower levels of certain serum nutrients and lifestyle factors like stress and smoking may contribute; hair oiling appeared protective.
15 citations
,
January 2015 in “Stem cells international” This study found that erythrocytes can be generated from human hair follicle mesenchymal stem cells with OCT4 expression, potentially serving as an alternative source for transfusions.
26 citations
,
January 2018 in “Annals of dermatology/Annals of Dermatology” This review examines current understanding of hair graying and suggests it may be caused by depletion of melanocyte stem cells due to genotoxic stress or dysfunctional melanocytes from oxidative stress.
2 citations
,
March 2020 in “Developmental cell” This study reported that stress can induce hair graying in mice through noradrenaline-mediated depletion of melanocyte stem cells in hair follicles, providing a mechanism that connects stress to hair color changes.
17 citations
,
January 2015 in “Pharmacognosy Research” In this study, the herbal hair colorant formulation HD-3, with a mix of specific herbs, was most effective at coloring hair and highly accepted by volunteers.
2 citations
,
November 2004 in “Blood” In this study, researchers reported that the Pinkie mutation in mice, affecting RXRa activity, leads to skewed Th1 development and suggests RXRa's role in Th2 differentiation, impacting immune responses.
January 2025 in “Figshare” In this case study, a 17-month-old girl experienced sudden hair depigmentation during septic shock hospitalization, suggesting systemic stress as a potential trigger for pediatric canities subita associated with diffuse alopecia areata.
9 citations
,
August 1980 in “Journal of Cutaneous Pathology” This study found that Rhodamin B staining of keratin was inconsistent across normal skin, epithelial tumors, and dermatoses, with notable differences in staining intensity between tricho-hyalin and keratohyalin granules.
2 citations
,
October 2016 in “Nutrition in clinical practice” This case report describes a rare instance of reversible melasma-like hyperpigmentation linked to vitamin B12 deficiency due to pernicious anemia, and explores possible mechanisms for this association.
6 citations
,
January 2014 in “Clinical hemorheology and microcirculation” This report presents a case of hereditary elliptocytosis in a 37-year-old woman with iron deficiency anemia, identifying a high percentage of elliptocytes in her blood after treatment.
2 citations
,
September 2020 in “Schweizer Archiv für Tierheilkunde” This study found that Swiss cattle exhibiting rat-tail syndrome are heterozygous for genetic variants linked to pigmentation and color dilution, likely due to Holstein introgression in the Simmental breed.
14 citations
,
January 1977 in “PubMed” This study found that a specific variant in hair keratin was present mainly in Caucasian samples, with few exceptions showing likely Caucasian admixture.
1 citations
,
March 1958 in “PubMed”
35 citations
,
January 2013 in “International Journal of Trichology” This study found that serum calcium, serum ferritin, and vitamin D3 levels were lower in students with premature graying of hair compared to controls, suggesting a potential role in the condition.
7 citations
,
January 2020 in “Nature” This study found that stress-induced signaling from the sympathetic nervous system in mice led to the depletion of stem cells in hair follicles, resulting in premature greying.
June 2025 in “Clinical Cosmetic and Investigational Dermatology” This study examined the factors contributing to gray hair, such as genetics and lifestyle, and found that while graying correlates with some health conditions, it is primarily a physiological process rather than a pathological one.
24 citations
,
January 2001 in “International Journal of Cancer” This study from Los Angeles supports the idea that using permanent hair dye may increase bladder cancer risk in US women, especially those with a slow NAT2 acetylation phenotype.
3 citations
,
March 2016 in “Experimental Dermatology” This study found that a hypomorphic mutation in the Hr gene contributes to the development of diet-induced pruritic atopic skin in mice, particularly when combined with dietary deficiencies of polyunsaturated fatty acids and starch.
1 citations
,
June 2011 in “Journal of The American Academy of Dermatology” This study found that iron deficiency was common in both women with hair loss and control subjects, with no higher incidence in the hair loss group.
178 citations
,
October 2001 in “Genes & Development” This study found that the mammalian hairless gene encodes a corepressor protein that interacts with thyroid hormone receptors, providing insights into hair loss syndromes in humans and mice.
10 citations
,
January 2010 in “Veterinary pathology” This study found that a newly identified mutation in the hairless gene in mice led to decreased Hr mRNA levels and changes in gene expression related to hair follicle development.
January 2004 in “Linchuang pifuke zazhi” In this study, all-trans retinoic acid was found to promote differentiation and inhibit proliferation of amelanotic melanocytes from human hair follicles, suggesting a potential role in melanogenesis.