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    Did you mean Receptor Tyrosine Kinase Signaling?
    Glossary Receptor Tyrosine Kinase Signaling

    cellular communication process involving protein receptors that regulate growth

    Receptor Tyrosine Kinase (RTK) Signaling is a cellular communication process where specific proteins on the cell surface, known as receptor tyrosine kinases, bind to signaling molecules like growth factors. This binding activates the receptors, causing them to add phosphate groups to certain tyrosines on themselves and other proteins, which then triggers a cascade of intracellular events that regulate cell growth, division, and survival. This pathway is crucial in many biological processes and is often implicated in diseases such as cancer when dysregulated.

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    1. 078 The transmembrane protein LRIG1 regulates receptor tyrosine kinases in skin development and homeostasis Journal of Investigative Dermatology · 2017
    2. Receptor tyrosine kinase Kit action in skin melanocytes: is it exclusively cell autonomous? Experimental Dermatology · 2015 · 1 citations
    3. Characterisation, genomic organisation, expression and function of the mEphA1 receptor Tyrosine Kinase 2007
    4. Safety Profile of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: A Disproportionality Analysis of FDA Adverse Event Reporting System Scientific Reports · 2020 · 58 citations
    5. Taiwanese Dermatological Association consensus for the prevention and management of epidermal growth factor receptor tyrosine kinase inhibitor-related skin toxicities Journal of the Formosan Medical Association · 2017 · 22 citations
    6. Acneiform eruptions caused by an epidermal growth factor receptor-tyrosine kinase inhibitor ZD 1839 Journal of the American Academy of Dermatology · 2004 · 1 citations
    7. Platycladus orientalis Leaf Extract Promotes Hair Growth via Non-Receptor Tyrosine Kinase ACK1 Activation Current Issues in Molecular Biology · 2024
    8. Clinical Manifestations of Hyperandrogenism and Ovulatory Dysfunction Are Not Associated with His1058 C/T SNP (rs1799817) Polymorphism of Insulin Receptor Gene Tyrosine Kinase Domain in Kashmiri Women with PCOS International Journal of Endocrinology · 2021 · 6 citations
    9. Comparison of pemetrexed and docetaxel as salvage chemotherapy for the treatment for nonsmall-cell lung cancer after the failure of epidermal growth factor receptor-tyrosine kinase inhibitors Journal of international medical research · 2014 · 12 citations
    10. 2,3,7,8‐Tetrachlorodibenzo‐<i>p</i>‐dioxin causes an increase in protein kinases growth hepatic associated with epidermal factor receptor in the plasma membrane Journal of Biochemical Toxicology · 1988 · 60 citations
    11. Expression Profiles of Tyrosine Kinases in Cultured Follicular Papilla Cells Versus Dermal Fibroblasts Journal of Investigative Dermatology · 2004 · 11 citations
    12. Cutaneous Adverse Events of Tyrosine Kinase Inhibitors in Endocrine Tumors: Clinical Features, Mechanisms, and Management Strategies Biomedicines · 2025
    13. Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects Current drug metabolism · 2009 · 508 citations
    14. Tyrosine kinase inhibition and grey hair The Lancet · 2003 · 59 citations
    15. Epidermal growth factor receptor mutant T790M-L858R-V948R inhibitor from Calophyllum inophyllum L. leaf as potential non-small cell lung cancer drugs Journal of pharmacy & pharmacognosy research · 2024
    16. Erlotinib-induced trichomegaly of eyelashes in lung cancer treatment: Epidermal growth factor receptor inhibitor side effect Dermatology Online Journal · 2025
    17. Signaling by the Platelet-Derived Growth Factor Receptor Family 2009
    18. MicroRNA control of signal transduction Nature Reviews Molecular Cell Biology · 2010 · 1066 citations
    19. Gab1 and Mapk Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence Cell reports · 2015 · 36 citations
    20. Anti-Acne Agents Attenuate FGFR2 Signal Transduction in Acne 2009 · 65 citations
    21. JAK INHIBITORS IN THE PATHOGENESIS OF ALOPECIA AREATA Zenodo (CERN European Organization for Nuclear Research) · 2026
    22. JAK INHIBITORS IN THE PATHOGENESIS OF ALOPECIA AREATA Zenodo (CERN European Organization for Nuclear Research) · 2026
    23. Botryococcus terribilis Ethanol Extract Exerts Anti-inflammatory Effects on Murine RAW264 Cells International Journal of Molecular Sciences · 2023 · 1 citations
    24. Identification of key genes and signaling pathways related to Hetian sheep wool density by RNA-seq technology PLOS ONE · 2022 · 7 citations
    25. Cutaneous reactions to chemotherapeutic drugs and targeted therapy for cancer Journal of the American Academy of Dermatology · 2014 · 88 citations
    26. Clinical management of cutaneous adverse events in patients on targeted anticancer therapies and immunotherapies: a national consensus statement by the Spanish Academy of Dermatology and Venereology and the Spanish Society of Medical Oncology Clinical & Translational Oncology · 2018 · 26 citations
    27. Periocular Manifestations of Afatinib Therapy Ophthalmic Plastic and Reconstructive Surgery · 2018 · 6 citations
    28. Hair Growth After Gefitinib Treatment Clinical Oncology · 2005 · 2 citations
    29. Targeted Treatments of Non-Small Cell Lung Cancer (NSCLC): Skin Toxicity Дерматовенерология Косметология · 2022 · 1 citations
    30. Severe scarring alopecia associated with combinational use of ficlatuzumab and gefitinib: a clinical and immunohistochemistry study Journal of dermatological science · 2012 · 1 citations