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    Glossary Receptor Tyrosine Kinase Signaling

    cellular communication process involving protein receptors that regulate growth

    Receptor Tyrosine Kinase (RTK) Signaling is a cellular communication process where specific proteins on the cell surface, known as receptor tyrosine kinases, bind to signaling molecules like growth factors. This binding activates the receptors, causing them to add phosphate groups to certain tyrosines on themselves and other proteins, which then triggers a cascade of intracellular events that regulate cell growth, division, and survival. This pathway is crucial in many biological processes and is often implicated in diseases such as cancer when dysregulated.

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    1. Platycladus orientalis Leaf Extract Promotes Hair Growth via Non-Receptor Tyrosine Kinase ACK1 Activation Current Issues in Molecular Biology · 2024
    2. Signaling by the Platelet-Derived Growth Factor Receptor Family 2009
    3. Gab1 and Mapk Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence Cell reports · 2015 · 36 citations
    4. Identification of key genes and signaling pathways related to Hetian sheep wool density by RNA-seq technology PLOS ONE · 2022 · 7 citations
    5. Cutaneous Adverse Events of Tyrosine Kinase Inhibitors in Endocrine Tumors: Clinical Features, Mechanisms, and Management Strategies Biomedicines · 2025
    6. Anti-Acne Agents Attenuate FGFR2 Signal Transduction in Acne 2009 · 65 citations
    7. JAK INHIBITORS IN THE PATHOGENESIS OF ALOPECIA AREATA Zenodo (CERN European Organization for Nuclear Research) · 2026
    8. MicroRNA control of signal transduction Nature Reviews Molecular Cell Biology · 2010 · 1066 citations
    9. Botryococcus terribilis Ethanol Extract Exerts Anti-inflammatory Effects on Murine RAW264 Cells International Journal of Molecular Sciences · 2023 · 1 citations
    10. 061 Selective inhibition of tyrosine kinase 2 prevents and restores interleukin-12-induced hair follicle immune privilege collapse: a novel approach to alopecia areata therapy? Journal of Investigative Dermatology · 2021
    11. c-Kit - The Novel Receptor: Physiological Roles, Downstream Signaling and Implications in Cancer Journal of Clinical Medical Research · 2021 · 4 citations
    12. Safety Profile of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: A Disproportionality Analysis of FDA Adverse Event Reporting System Scientific Reports · 2020 · 58 citations
    13. Receptor tyrosine kinase Kit action in skin melanocytes: is it exclusively cell autonomous? Experimental Dermatology · 2015 · 1 citations
    14. 078 The transmembrane protein LRIG1 regulates receptor tyrosine kinases in skin development and homeostasis Journal of Investigative Dermatology · 2017
    15. Suppression of Wnt/β-catenin signaling by EGF receptor is required for hair follicle development Molecular Biology of the Cell · 2018 · 25 citations
    16. Taiwanese Dermatological Association consensus for the prevention and management of epidermal growth factor receptor tyrosine kinase inhibitor-related skin toxicities Journal of the Formosan Medical Association · 2017 · 22 citations
    17. Clinical Manifestations of Hyperandrogenism and Ovulatory Dysfunction Are Not Associated with His1058 C/T SNP (rs1799817) Polymorphism of Insulin Receptor Gene Tyrosine Kinase Domain in Kashmiri Women with PCOS International Journal of Endocrinology · 2021 · 6 citations
    18. Bioinformatic analysis of gene expression data reveals Src family protein tyrosine kinases as key players in androgenetic alopecia Frontiers in Medicine · 2023
    19. Inhibition of a signaling modality within the gp130 receptor enhances tissue regeneration and mitigates osteoarthritis Science Translational Medicine · 2023 · 1 citations
    20. Expression Profiles of Tyrosine Kinases in Cultured Follicular Papilla Cells Versus Dermal Fibroblasts Journal of Investigative Dermatology · 2004 · 11 citations
    21. Tyrosine kinase inhibition and grey hair The Lancet · 2003 · 59 citations
    22. Erlotinib-induced trichomegaly of eyelashes in lung cancer treatment: Epidermal growth factor receptor inhibitor side effect Dermatology Online Journal · 2025
    23. 700 Tyrosine kinase 2 inhibition rescues hair follicles from IL-12–mediated immune privilege collapse and reverses the induction of human alopecia areata in a humanized mouse model Journal of Investigative Dermatology · 2022
    24. TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia Cell Death and Disease · 2016 · 38 citations
    25. Clinical management of cutaneous adverse events in patients on targeted anticancer therapies and immunotherapies: a national consensus statement by the Spanish Academy of Dermatology and Venereology and the Spanish Society of Medical Oncology Clinical & Translational Oncology · 2018 · 26 citations
    26. Precision therapeutics in non-scarring alopecia: a systemic genomic and pathway-based framework for targeted interventions ADMET & DMPK · 2025
    27. Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases Frontiers in immunology · 2019 · 88 citations
    28. Cutaneous reactions to chemotherapeutic drugs and targeted therapy for cancer Journal of the American Academy of Dermatology · 2014 · 88 citations
    29. Targeted Treatments of Non-Small Cell Lung Cancer (NSCLC): Skin Toxicity Дерматовенерология Косметология · 2022 · 1 citations
    30. Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways Journal of Cellular Biochemistry · 2005 · 24 citations