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    Did you mean Receptor Tyrosine Kinase Signaling?
    Glossary Receptor Tyrosine Kinase Signaling

    cellular communication process involving protein receptors that regulate growth

    Receptor Tyrosine Kinase (RTK) Signaling is a cellular communication process where specific proteins on the cell surface, known as receptor tyrosine kinases, bind to signaling molecules like growth factors. This binding activates the receptors, causing them to add phosphate groups to certain tyrosines on themselves and other proteins, which then triggers a cascade of intracellular events that regulate cell growth, division, and survival. This pathway is crucial in many biological processes and is often implicated in diseases such as cancer when dysregulated.

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    1. Receptor tyrosine kinase Kit action in skin melanocytes: is it exclusively cell autonomous? Experimental Dermatology · 2015 · 1 citations
    2. Tyrosine kinase inhibition and grey hair The Lancet · 2003 · 59 citations
    3. Identification of key genes and signaling pathways related to Hetian sheep wool density by RNA-seq technology PLOS ONE · 2022 · 7 citations
    4. Hair graying and loss induced by imatinib mesylate The Journal of Dermatology · 2013 · 7 citations
    5. c-Kit - The Novel Receptor: Physiological Roles, Downstream Signaling and Implications in Cancer Journal of Clinical Medical Research · 2021 · 4 citations
    6. Platycladus orientalis Leaf Extract Promotes Hair Growth via Non-Receptor Tyrosine Kinase ACK1 Activation Current Issues in Molecular Biology · 2024
    7. Clinical Manifestations of Hyperandrogenism and Ovulatory Dysfunction Are Not Associated with His1058 C/T SNP (rs1799817) Polymorphism of Insulin Receptor Gene Tyrosine Kinase Domain in Kashmiri Women with PCOS International Journal of Endocrinology · 2021 · 6 citations
    8. Expression Profiles of Tyrosine Kinases in Cultured Follicular Papilla Cells Versus Dermal Fibroblasts Journal of Investigative Dermatology · 2004 · 11 citations
    9. Cutaneous Adverse Events of Tyrosine Kinase Inhibitors in Endocrine Tumors: Clinical Features, Mechanisms, and Management Strategies Biomedicines · 2025
    10. Clinical management of cutaneous adverse events in patients on targeted anticancer therapies and immunotherapies: a national consensus statement by the Spanish Academy of Dermatology and Venereology and the Spanish Society of Medical Oncology Clinical & Translational Oncology · 2018 · 26 citations
    11. Cutaneous reactions to chemotherapeutic drugs and targeted therapy for cancer Journal of the American Academy of Dermatology · 2014 · 88 citations
    12. Gab1 and Mapk Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence Cell reports · 2015 · 36 citations
    13. Botryococcus terribilis Ethanol Extract Exerts Anti-inflammatory Effects on Murine RAW264 Cells International Journal of Molecular Sciences · 2023 · 1 citations
    14. The Dark Side of Gefitinib: Reflectance Confocal Microscopy Applied to Hair Hyperpigmentation Skin Appendage Disorders · 2019 · 4 citations
    15. A Case of Inflammatory Nonscarring Alopecia Associated With the Tyrosine Kinase Inhibitor Nilotinib JAMA Dermatology · 2013 · 16 citations
    16. Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways Journal of Cellular Biochemistry · 2005 · 24 citations
    17. Suppression of Wnt/β-catenin signaling by EGF receptor is required for hair follicle development Molecular Biology of the Cell · 2018 · 25 citations
    18. Phase I safety and pharmacokinetic study of SU-014813 in combination with docetaxel in patients with advanced solid tumours European Journal of Cancer · 2011 · 22 citations
    19. Tyrosine Kinase Inhibitors against Cancer: Their Safety in 216 Moroccan Patients Journal of Cancer Therapy · 2021
    20. Immunohistochemical study assessing stem cell factor receptor C-kit in patients with alopecia Egyptian Journal of Dermatology and Venereology · 2020
    21. The PDGF/PDGFR pathway as a drug target Molecular Aspects of Medicine · 2017 · 182 citations
    22. Keratosis Pilaris-like Eruption during Treatment of Chronic Myeloid Leukemia with Tyrosine Kinase Inhibitors: Literature Review and Report of a Case Related to Imatinib Journal of clinical medicine · 2023
    23. Bioinformatic analysis of gene expression data reveals Src family protein tyrosine kinases as key players in androgenetic alopecia Frontiers in Medicine · 2023
    24. Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases Frontiers in immunology · 2019 · 88 citations
    25. Dasatinib-Induced Leukotrichia in a Patient With Chronic Myelogenous Leukemia JAMA Dermatology · 2013 · 9 citations
    26. Safety of Tyrosine Kinase Inhibitors in Patients With Differentiated Thyroid Cancer: Real-World Use of Lenvatinib and Sorafenib in Korea Frontiers in Endocrinology · 2019 · 39 citations
    27. Activity of Sorafenib against Desmoid Tumor/Deep Fibromatosis Clinical Cancer Research · 2011 · 215 citations
    28. Alopecia areata: from immunopathogenesis to emerging therapeutic approaches Frontiers in Immunology · 2025
    29. Unusual progression of renal cell carcinoma with carcinomatosis peritoneii and Krukenberg tumour and alopecia with sunitinib therapy in young female World journal of surgical oncology · 2018 · 4 citations
    30. Rapid hair depigmentation in patient treated with pazopanib BMJ Case Reports · 2018 · 8 citations