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In this study on rats, rutin showed dose-dependent improvements in hormonal, antioxidant, and lipid profiles related to polycystic ovary syndrome, with effects comparable to metformin.

This study found that finasteride treatment in male rats led to enduring effects on depressive-like behavior, hippocampal neurogenesis and neuroinflammation, and gut microbiota composition after withdrawal.

The study observed that finasteride reduced fertility in male Sprague-Dawley rats by impairing the formation of copulatory plugs, an effect considered specific to rats and not applicable to species without this reproductive feature.

This study found that rats fed diets with heated corn or peanut oil showed signs of toxicity, including liver and kidney weight increases, diarrhea, and ceased spermatogenesis, compared to those consuming fresh oils.

In this animal study, rats given high doses of ethynylestradiol showed dose-related estrogenic effects, delayed tumor onset in females, and no overall increase in tumor incidence compared to controls.

Continuous light exposure in rats leads to PCOS-like symptoms and suggests sleep habits might affect the disorder's development.

In this study using rats, finasteride-induced DHT deficiency led to morphological changes in seminiferous tubules, linked with altered junctional protein expression, potentially impairing fertility.

Using testosterone-stimulated weanling rats can effectively replace castrated rats for anti-androgen testing, reducing animal stress.

This study found that feeding norethindrone acetate to albino rats over two years caused various dose-related health effects, such as growth retardation and liver changes, but did not increase overall tumor incidence.

In this study on rats, valproic acid was associated with reduced biotinidase enzyme activity and higher alopecia rates, but biotin supplementation did not significantly affect alopecia occurrence.

This study found that large excisional wounds in rats across seven strains do not regenerate new hair follicles, unlike in mice, possibly due to differences in epidermal competence and transcriptional profiles.

Niacin deficiency makes rats more sensitive to cancer-causing chemicals.

Caffeine becomes more toxic in rats when food intake is reduced by over 50%.

This study reports that distinct scaly dermatoses in rats can be caused by deficiencies in vitamin H, vitamin B6, or lactoflavin, each preventable or treatable through nutritional adjustments.

This study observed that electro-acupuncture reduced global DNA methylation and DNMT3b expression in a PCOS-like rat model, suggesting a role of hypothalamic DNA methylation in PCOS development and treatment.

In this study, testosterone increased the expression of epithelial sodium channel proteins and mRNAs in rat kidneys, suggesting a potential mechanism for its effect on blood pressure through enhanced sodium reabsorption.

Changing mineral levels in rats' diets can prevent kidney stones, affect hair growth, and influence weight gain.

This study describes a novel hairless mutant rat strain, F344-Hr(krh), developed via ENU mutagenesis, which provides a model for skin disease and potentially focal glomerulosclerosis due to specific genetic mutations.

This study found that C57BL/6 mice and Sprague–Dawley rats show distinct distributions of eccrine sweat glands and hair follicles in their volar skin, suggesting these models should be selected according to research focus on skin appendages.

This study in rats found that a new hydroxypropyl-β-cyclodextrin formulation of minoxidil reduced the adverse cardiovascular and proliferative effects seen with traditional minoxidil solutions.

Among young rats, this study found that a liquid protein diet significantly affects body condition but has minimal impact on gingival collagen metabolism.

This study found that while flour irradiation disrupted the physiology of Tribolium confusum, it also caused significant weight loss and biochemical changes in rats fed on irradiated flour.

This study found that administering Neem ethanol extract to pregnant and lactating rats did not cause developmental abnormalities or toxicity in the offspring at tested doses.

This study in hairless rats suggests that the deletion of specific hair keratin genes contributes to hypotrichosis and highlights the strain's potential as a model for hair follicle research.

Flutamide-induced hypospadias in rats slows down early wound healing.

In this study involving rats with letrozole-induced polycystic ovary syndrome, Agaricus subrufescens significantly reduced blood glucose, total cholesterol, testosterone levels, and renal markers, suggesting its potential protective effects on both metabolic and reproductive parameters.

This study in neonatal rats found that inhibiting neurosteroid synthesis with finasteride unexpectedly reduced the severity and duration of neonatal seizures following birth asphyxia, maintained cognitive functions, but increased anxiety-like behaviors, highlighting a complex role of neurosteroids in hypoxic-ischemic encephalopathy outcomes.

Among adult male rats, this study found that combined exposure to lithium carbonate and lead acetate over 28 days led to synergistic cardiotoxic effects, evidenced by oxidative stress, ECG abnormalities, and molecular markers of increased apoptosis, despite no observable structural damage to myocardial tissue.