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This study observed that N-palmitoylethanolamine (PEA) may relieve pain by enhancing de novo neurosteroid synthesis, evidenced by increased allopregnanolone levels and protein expression in pain models, dependent on PPAR-α.

Hair removal with intense pulsed light can cause rare skin lesions that are hard to fully treat.

A woman developed a severe skin reaction called toxic epidermal necrolysis after taking the antibiotic cephalexin.

This case report observed a dramatic improvement in a 15-year-old girl's pachyonychia congenita symptoms during chemotherapy for Ewing sarcoma, suggesting chemotherapy's potential role in managing hyperkeratotic conditions.

This study found that cPPARγ and dnPPARγ isoforms are differentially expressed in healthy human skin, suggesting that PPARγ modulators may have compartment-specific effects depending on isoform presence.

This study reports a novel mutation in the TP63 gene associated with T and B cell lymphopenia in an EEC patient, suggesting that EEC diagnosis should include TREC assay and evaluation for immunodeficiency.

This study found that mirex and TPA promote papilloma formation in CD-1 mouse skin through distinct populations of mutant Ha-ras cells, resulting in additive tumor yields.

This study examines how conditions like PSSD, Long COVID, and ME/CFS form a "Post-Exposure Syndromes" family, initiated by transient exposures but persisting due to complex state-space dynamics, and suggests improving pharmacovigilance to better address and understand these persistent syndromes.

This study found that a history of smoking significantly predicted a more refractory course of palmoplantar pustulosis, with associated comorbidities often including hypertension, type 2 diabetes mellitus, and thyroid diseases.

This review discusses erosive pustular dermatosis of the scalp, highlighting its wide variety of causes and multiple effective treatment options beyond high-potency topical steroids, and reports no new clinical results.

This study explored using large language models to automatically identify monkeypox cases from electronic medical records, finding that models based on DeepSeek features performed better than traditional methods, with logistic regression showing high accuracy in detecting key symptoms like fever and rash.

This study found that Hex gene expression patterns in chick embryo dorsal skin during feather bud development suggest a significant role in initiating feather morphogenesis.

Mutations in the TSPEAR gene cause a new form of ectodermal dysplasia affecting hair and tooth development.

In this study, researchers investigated the role of the ATX-LPA axis in asthma pathogenesis using human and mouse models and highlighted the potential for developing new ATX inhibitors as effective asthma treatments.

This report describes three cases of erythromelanosis follicularis faciei et colli showing significant improvement in facial telangiectasia following treatment with a 595-nm pulsed dye laser, with minimal recurrence observed during follow-up.

In this case study, a 26-year-old female with PLEC mutations and features of muscular dystrophy and myasthenia gravis showed significant improvement in symptoms following steroid treatment.

This report describes a case of widespread Porokeratotic eccrine and hair follicle nevus in a 15-year-old woman with keratitis-ichthyosis-deafness syndrome, involving both eccrine ostia and hair follicle infundibula.

This phase Ib study found that combining pegylated liposomal doxorubicin and pembrolizumab was well-tolerated and effective, with durable antitumor responses and a median survival of over two years in heavily pretreated ER-positive metastatic breast cancer patients.

This study found that cepharanthine significantly inhibits EqHV-8 infection in vitro and improves lung tissue pathology in infected mice by reducing oxidative stress through specific signaling pathways, suggesting its potential as a treatment for equid herpesvirus type 8.

This article discusses the use of methotrexate for treating generalized pustular psoriasis in a 2-year-old child, providing a specific case study but reporting no new clinical results.

This study used a zebrafish model and advanced mass spectrometry to identify 11 metabolites of epristeride, revealing significant effects on purine metabolism and aromatic amino acid biosynthesis, which may aid in developing anti-doping detection methods.

This study reports that improvements to the EczemaNet pipeline, incorporating pixel-level segmentation and data augmentation, enhanced the reliability and interpretability of assessing atopic dermatitis severity from digital images.

This study found that Polycomb repressive complex 1 is crucial for skin development and stem cell specification, influencing gene activity beyond its known repressor functions.

This study found that administering botulinum toxin A via Flex-PADs to mouse footpads inhibited sweating similarly to traditional injections, suggesting a promising patient-friendly delivery method for hyperhidrosis treatment.

The study found that cyproterone acetate could be released over 15 days using coconut oil mixed with certain wax inhibitors, though further safety studies are needed.

This study suggests PPAR isotypes play distinct roles in skin, influencing epidermal barrier formation, sebocyte differentiation, and lipid production, with potential implications for treating skin disorders.

In this study, researchers observed that P2X3-immunoreactive fibers extensively innervate the epidermis of rats, suggesting a primary role in detecting noxious stimuli in cutaneous tissue.

This study found that CPA-loaded nanoparticles, particularly SLN formulations, increased CPA epidermal penetration compared to a conventional cream and may reduce side effects in treating androgen-dependent conditions.

Ixekizumab helps improve life quality, physical ability, and work performance in patients with psoriatic arthritis who haven't used biologic drugs before.

This article discusses the roles of pediatrics and dermatology departments at Yale University School of Medicine, but reports no specific clinical results.